Vivek K. Unni, M.D., Ph.D.

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503 494-7772

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Dr. Unni’s research focuses on understanding the role of the protein alpha-synuclein in the mechanisms of Parkinson’s Disease (PD). Multiple lines of evidence suggest that simply increasing levels of this protein by seemingly modest amounts can cause both genetic and idiopathic forms of PD. Dr. Unni uses transgenic models which over-express alpha-synuclein to study how abnormally high levels of this protein cause self-aggregation and neuronal dysfunction in the living brain, using advanced biochemical and in vivo multiphoton imaging techniques.

Selected Publications

"Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease," Journal of Neuroscience (Vol: 34, Issue: 6, Page 2037-2050) - 2014

"Specific splice variants are associated with Parkinson's disease," Movement Disorders (Vol: 28, Issue: 12, Page 1724-1727) - 2013

"Alpha-synuclein's degradation in vivo: Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease," Autophagy (Vol: 8, Issue: 2, ) - 2012

"Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.," Autophagy (Vol: 8, Issue: 2, Page 281-283) - 2012

"Guidelines for the use and interpretation of assays for monitoring autophagy," Autophagy (Vol: 8, Issue: 4, Page 445-544) - 2012


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503 494-7772

Memberships & Associations

American Academy of Neurology The Movement Disorders Society The Society for Neuroscience