OHSU

Charles Keller

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Background

Dr. Keller’s research focuses on the development of more effective, less toxic therapies for childhood sarcomas including the muscle cancer, rhabdomyosarcoma, and the childhood brain tumor, medulloblastoma. His laboratory's special interest is advanced disease that has spread beyond the initial location of the cancer. Dr. Keller is an Associate Professor and Leader of the Pediatric Cancer Biology Program in the Pape' Family Pediatric Research Institute, Department of Pediatrics. Dr. Keller also directs the Pediatric Preclinical Testing Initiative, an NCI-affiliated childhood cancer drug testing program. Dr. Keller previously attended Tulane University where he received a degree in Biomedical Engineering prior to attending Baylor College of Medicine where he received his M.D. degree. After completing his internship and residency in Pediatrics at Texas Children's Hospital, Dr. Keller trained in Pediatric Hematology-Oncology at the University of Utah.


Selected Publications

"Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma," PLoS Genetics (Vol: 10, Issue: 1, ) - 2014

"Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma," Proceedings of the National Academy of Sciences of the United States of America (Vol: 111, Issue: 14, Page 5349-5354) - 2014

"Microscopic computed tomography-based skeletal phenotyping for genetic model organisms," Methods in Molecular Biology (Vol: 1092, Page 221-226) - 2014

"Microscopic computed tomography-based skeletal phenotyping for genetic model organisms," Methods in Molecular Biology (Vol: 1092, Page 221-226) - 2014

"Microscopic computed tomography-based virtual histology of embryos," Methods in Molecular Biology (Vol: 1092, Page 291-296) - 2014

 

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Contact

  Email Charles Keller

503 494-8311

Memberships & Associations

American Academy of Pediatrics American Association for Cancer Research Children’s Oncology Group