OHSU

Shaun Morrison

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Background

Specific circuits within the CNS are dedicated to the maintenance of homeostasis and an optimal cellular environment through regulation of autonomic function. Disease states such as fever, obesity, diabetes, hypertension, autonomic hyperreflexia and cardiac arrhythmia are associated with altered regulation of the sympathetic outflow to cardiovascular and non-cardiovascular tissues.

The Morrison lab's research uses electrophysiological and anatomical approaches to understand the functional organization, rhythmicities, developmental influences and pharmacology of the CNS circuits that regulate the sympathetic outflows controlling variables critical for homeostasis such as body temperature, energy expenditure, blood glucose, blood pressure, cardiac output and plasma catecholamines.

We are currently pursuing three main areas of investigation in the rapidly growing field of autonomic neuroscience. The first concerns the regulation of the sympathetic outflow to brown adipose tissue in the rat as a model system for gaining insight into the central circuits involved in regulating energy metabolism and body temperature. The results of these studies will be relevant to altered thermoregulation occurring during fever and to the increasing public health problem of obesity, which can be viewed as an imbalance between energy intake and metabolism. We are also studying the CNS regulation of catecholamine release from the adrenal medulla, an important component of a variety of stress responses including hypoglycemia, hemorrhage, and exercise. The third area of research involves the organization of the medullary pathways regulating sympathetic outflow to the cardiovascular system. These experiments have indicated a novel source of excitatory input to the neural circuits that generate sympathetic outflow, a result which will contribute to our understanding of the elevated blood pressure in models of hypertension such as the spontaneously hypertensive rat. By addressing basic questions in autonomic neuroscience, we seek to understand the altered regulation of sympathetic outputs characteristic of several disease states.

PREVIOUS POSITIONS

Postdoctoral fellow, Department of Pharmacology, Michigan State University (1980-84)

Assistant professor, Division of Neurobiology, Cornell University Medical College (1984-90)

Professor, Department of Physiology at Northwestern University Medical School (1990-2001)

Senior scientist, Neurological Sciences Institute, OHSU (2001)

Senior scientist, ONPRC Division of Neuroscience (2008)

Professor, Neurological Surgery, OHSU (2010)

EDUCATION

BA, Wesleyan University, CT (1970)

PhD, Physiology and Biophysics, University of Vermont, VT (1980)

Publication of Distinction

2010 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section: Central neural pathways for thermoregulatory cold defense. J Appl Physiol 110:1137-1149, 2011


Selected Publications

"Autonomic regulation of brown adipose tissue thermogenesis in health and disease: Potential clinical applications for altering BAT thermogenesis," Frontiers in Neuroscience ( Issue: 8 FEB, ) - 2014

"Central neural regulation of brown adipose tissue thermogenesis and energy expenditure," Cell Metabolism (Vol: 19, Issue: 5, Page 741-756) - 2014

"Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat," Journal of Neuroscience (Vol: 33, Issue: 36, Page 14512-14525) - 2013

"Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models," Journal of Comparative Neurology (Vol: 521, Issue: 8, Page 1891-1914) - 2013

"Highlights in basic autonomic neurosciences: Central adenosine A1 receptor - The key to a hypometabolic state and therapeutic hypothermia?," Autonomic Neuroscience: Basic and Clinical (Vol: 176, Issue: 1-2, Page 1-2) - 2013

 

Contact

  Email Shaun Morrison

503-494-1560