Scott W Wong, Ph.D.
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Understanding how viruses cause disease is important to the development of effective antiviral therapies and potential vaccines.
The long-term goal of the Wong laboratory is to understand how viruses cause disease. This is important in developing effective antiviral therapies and potential vaccines. The Wong lab is currently investigating two types of viruses: orthopoxviruses, which induce disease similar to smallpox; and herpesviruses, which can induce severe disease in individuals. Some of these viruses are very specific for their natural hosts, a factor that complicates the ability to study the mechanisms of the human viruses in an animal model. An alternative approach is to utilize animal models that harbor viruses that are closely related to the human virus. One animal model that has proven to be invaluable in understanding the mechanisms of infectious disease and for vaccine development is the nonhuman primate.
By employing molecular, genetic and virological techniques, members of Dr. Wong’s laboratory examine how these nonhuman primate viruses infect and replicate in cell culture and eventually how they cause illnesses in vivo. They have shown that experimental inoculation of normal monkeys with orthopoxviruses causes disease that is virtually identical to smallpox and have identified novel viral proteins utilizing proteomic analysis that may facilitate disease. Additionally, experimental infection of immunocompromised monkeys with simian herpesviruses results in disease manifestations that closely resemble those observed in humans infected with the human immunodeficiency virus (HIV). Utilizing these techniques they are identifying the viral determinants that contribute to disease and are devising novel recombinant molecules to help prevent viral pathogenesis.
Summary of Current Research
Dr. Wong received his PhD from Stanford University School of Medicine in 1987 and performed post-doctoral research at Stanford Medical School and Harvard University Medical School. He came to the center in 1991 as an Assistant Scientist in the Division of Pathobiology and Immunology, where he is now a Senior Scientist. In addition to his appointment at the ONPRC, he is an Associate Scientist in the Vaccine and Gene Therapy Institute and an Associate Professor of Molecular Microbiology and Immunology in the OHSU School of Medicine.
"T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence,"
"Erratum: Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions (Journal of Proteome Research (2008) 7:3 (960-968) DOI: 10.1021/pr070432+),"
"Genomic characterization of japanese macaque rhadinovirus, a novel herpesvirus isolated from a nonhuman primate with a spontaneous inflammatory demyelinating disease,"
"Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer,"
"Rhesus macaque rhadinovirus-associated disease,"