OHSU

Amanda K McCullough, Ph.D.

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Background

Dr. McCullough received her doctoral degree in cellular and molecular biology from the University of Vermont. She completed postdoctoral training at Oregon Health & Science University and the University of Texas Medical Branch in Galveston, Texas. She was an Assistant Professor in the Department of Human Biological Chemistry and Genetics at the University of Texas before joining Center for Research on Occupational and Environmental Toxicology (CROET) at OHSU in August 2003.

Research in the McCullough laboratory is focused on the biochemical mechanisms of DNA repair systems and the regulation and roles of DNA repair in cellular responses to environmental stress. Ultimately, we are interested in correlating alterations in these systems with human cancers, aging and other disease states. Currently our research is focused on: 1) cellular pathways for the tolerance and repair of DNA-protein crosslinks; 2) biochemical mechanisms and therapeutic applications of ultraviolet (UV) light-induced DNA damage-specific glycosylases; and 3) mechanisms and regulation of human oxidative DNA damage-specific repair and how defects in these pathways contribute to colorectal cancers and metabolic disease.


Selected Publications

"Inhibition of DNA glycosylases via small molecule purine analogs," PLoS ONE (Vol: 8, Issue: 12, ) - 2013

"Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway," DNA Repair (Vol: 11, Issue: 3, Page 236-246) - 2012

"Regulation of DNA glycosylases and their role in limiting disease," Free Radical Research (Vol: 46, Issue: 4, Page 460-478) - 2012

"Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase," DNA Repair (Vol: 10, Issue: 10, Page 1014-1022) - 2011

"TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage," Journal of Investigative Dermatology (Vol: 131, Issue: 3, Page 753-761) - 2011

 

Contact

  Email Amanda McCullough

503 494-9958