OHSU

Mushui Dai, M.D., Ph.D.

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Background

Dr. Dai’s research focuses on the understanding of the biological function and molecular mechanisms of the p53 tumor suppression and c-Myc oncogenic pathways. Dr. Dai’s prior research has demonstrated that some ribosomal proteins play a critical role in regulating both the MDM2-p53 and c-Myc pathway in response to nucleolar stress. His findings help to understand how ribosomal biogenesis is tightly coordinated with cell cycle progression during normal homeostasis. Currently, Dr. Dai’s lab is investigating (1) the mechanism underlying the RP inhibition of the MDM2-p53 pathway; (2) the mechanism underlying the regulation of c-myc mRNA stability by L11; (3) the role of deubiquitination in controlling p53 protein stability and activity by in response to stress. Dr. Dai’s research would provide important information on how p53 tumor and c-Myc oncoprotein are tightly controlled in both physiological and stress conditions, thereby providing a possible means to manipulate p53 and c-Myc function in cancer cells.


Selected Publications

"The Core Four Subspecialties in Esthetic Surgery," Clinics in Plastic Surgery (Vol: 40, Issue: 1, Page xvii) - 2013

"Lateral canthoplasty with acellular cadaveric dermal matrix graft (AlloDerm) reinforcement," Ophthalmic Plastic and Reconstructive Surgery (Vol: 28, Issue: 1, Page e29-e31) - 2012

"Physician confidence in fillers and neurotoxins: A national survey," Archives of Facial Plastic Surgery (Vol: 14, Issue: 1, Page 67-68) - 2012

"Facial soft-tissue fillers conference: Assessing the state of the science," Plastic and Reconstructive Surgery (Vol: 127, Issue: SUPPL. 4 S, Page 22S-122eS) - 2011

"Facial soft-tissue fillers conference: Assessing the state of the science," Journal of the American Academy of Dermatology (Vol: 64, Issue: 4 SUPPL. 1, Page S66-S85) - 2011

 

Contact

  Email Mushui Dai

503 494-7719