OHSU

Maureen Hoatlin, Ph.D.

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Background

We are interested in understanding how cells maintain genomic stability. One of the mechanisms that regulates this critical process is defective in Fanconi anemia (FA), a genetic model for human susceptibility to cancer. FA is a rare but devastating multi-gene disease thought to have an underlying defect in DNA interstrand crosslink repair.

Our lab pioneered the use of cell-free assays for FA proteins in extracts from Xenopus eggs. These extracts allow analysis of FA protein function and post-translational modifications in a context that is permissive for naturally-regulated DNA synthesis. The recruitment of Fanconi proteins to chromatin in S-phase is providing us with a biochemical platform for elucidating the molecular function of the Fanconi proteins during the DNA damage response.


Selected Publications

"Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer," Nature Communications (Vol: 4, ) - 2013

"GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer," Nature Genetics (Vol: 45, Issue: 4, Page 362-370) - 2013

"Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31," Nature Communications (Vol: 4, ) - 2013

"Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer," Nature Genetics (Vol: 45, Issue: 4, Page 371-384) - 2013

"A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network," Molecular Cell (Vol: 47, Issue: 1, Page 61-75) - 2012

 

Contact

  Email Maureen Hoatlin

503 494-1123