Bill Hoon Chang, M.D., Ph.D.

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503 346-0640 or 877 346-0640

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Dr. Chang's research focuses on understanding the biochemical mechanism responsible for resistance in refractory and relapse leukemias. Identifying these mechanisms will aid in the development of new therapies for these resistant diseases. Using RNA interference technologies he has been able to identify new biochemical targets for therapy. Dr. Chang's research continues in collaboration with the Children's Oncology Group to develop these targets for new therapies to these cancers. 

Selected Publications

"Comparison of methods to identify aberrant expression patterns in individual patients: Augmenting our toolkit for precision medicine," Genome Medicine (Vol: 5, Issue: 11, ) - 2013

"Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening," Cancer Research (Vol: 73, Issue: 1, Page 285-296) - 2013

"Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML," New England Journal of Medicine (Vol: 368, Issue: 19, Page 1781-1790) - 2013

"TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia," Cancer Discovery (Vol: 3, Issue: 5, Page 564-577) - 2013

"Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia," Genome Research (Vol: 22, Issue: 10, Page 1833-1844) - 2012


OHSU Doernbecher Children's Hospital

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Memberships & Associations

American Academy of Pediatrics

American Society of Pediatric Hematology and Oncology

American Society of Hematology

American Society of Clinical Oncology

American Society for Blood and Marrow Transplantation

American Association for Cancer Research