OHSU

Michael C. Heinrich, M.D.

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Professor

Email: 
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Office: 
503 494-6594

Lab Page: http://www.heinrich-corless.net/


Background

Dr. Heinrich's research includes both preclinical identification of novel molecular targets and testing of new agents in the laboratory and the clinic. This includes both genomics research using high-throughput gentoyping to identify oncogenic mutations and testing of new compounds in cellular and biochemical assays. Dr. Heinrich’s laboratory is particularly expert in the analysis of inhibitors of oncogenic receptor tyrosine kinases such as KIT, PDGFRA and FLT3.


Summary of Current Research

Additional special interests

Development of novel tyrosine kinase inhibitors for treatment of human cancers


Selected Publications

"Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms," Molecular Cancer (Vol: , Issue: , Page 19-) - 2013

"Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping," Journal of Molecular Diagnostics (Vol: 15, Issue: 2, Page 171-176) - 2013

"Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors," Nature Genetics (Vol: 45, Issue: 2, Page 131-132) - 2013

"BRAF mutant gastrointestinal stromal tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance," Oncotarget (Vol: 4, Issue: 2, Page 310-315) - 2013

"Multiplex high-throughput gene mutation analysis in acute myeloid leukemia," Human Pathology (Vol: 43, Issue: 12, Page 2167-2176) - 2012

 

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  Email Michael Heinrich

503 494-6594

Memberships & Associations

American Society of Clinical Oncology
American Society of Hematology
Fellow, American College of Physicians
American Association of Cancer Research
Alpha Omega Alpha