Mushui Dai, M.D., Ph.D.

Email:: click here
Phone:: 503 494-7719; Lab Page: http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/molecular-and-medical-genetics/people/primary-faculty/mu-shui-dai.cfm

Background

Dr. Dai's research focuses on the understanding of the biological function and molecular mechanisms of the p53 tumor suppression and c-Myc oncogenic pathways. Dr. Dai's prior research has demonstrated that some ribosomal proteins play a critical role in regulating both the MDM2-p53 and c-Myc pathway in response to nucleolar stress. His findings help to understand how ribosomal biogenesis is tightly coordinated with cell cycle progression during normal homeostasis. Currently, Dr. Dai's lab is investigating (1) the mechanism underlying the RP inhibition of the MDM2-p53 pathway; (2) the mechanism underlying the regulation of c-myc mRNA stability by L11; (3) the role of deubiquitination in controlling p53 protein stability and activity by in response to stress. Dr. Dai's research would provide important information on how p53 tumor and c-Myc oncoprotein are tightly controlled in both physiological and stress conditions, thereby providing a possible means to manipulate p53 and c-Myc function in cancer cells.

Selected Publications

"The Core Four Subspecialties in Esthetic Surgery," Clinics in Plastic Surgery (Vol: 40, Issue: 1, Page xvii) - 2013

"Physician confidence in fillers and neurotoxins: A national survey," Archives of Facial Plastic Surgery (Vol: 14, Issue: 1, Page 67-68) - 2012

"Lateral canthoplasty with acellular cadaveric dermal matrix graft (AlloDerm) reinforcement," Ophthalmic Plastic and Reconstructive Surgery (Vol: 28, Issue: 1, Page e29-e31) - 2012

"Reply re: "Use of a Chitosan-Based Hemostatic Dressing in Dacryocystorhinostomy"," Ophthalmic Plastic and Reconstructive Surgery (Vol: 27, Issue: 4, Page 304-) - 2011

"Long-term treatment of glabellar rhytides using onabotulinumtoxina," Dermatologic Surgery (Vol: 37, Issue: 7, Page 918-928) - 2011

"Facial soft-tissue fillers: Assessing the state of the science conference - Proceedings report," Plastic and Reconstructive Surgery (Vol: 127, Issue: SUPPL. 4 S, Page 9S-21S) - 2011

"Facial soft-tissue fillers conference: Assessing the state of the science," Plastic and Reconstructive Surgery (Vol: 127, Issue: SUPPL. 4 S, Page 22S-122eS) - 2011

"Facial soft-tissue fillers conference: Assessing the state of the science," Journal of the American Academy of Dermatology (Vol: 64, Issue: 4 SUPPL. 1, Page S66-S85) - 2011

"Facial soft-tissue fillers: Assessing the state of the science conference - Proceedings report," Journal of the American Academy of Dermatology (Vol: 64, Issue: 4 SUPPL. 1, Page S53-S65) - 2011

"Upper eyelid margin mass excision technique: Supraciliary approach," Ophthalmic Plastic and Reconstructive Surgery (Vol: 27, Issue: 1, Page 48-51) - 2011

"Use of a chitosan-based hemostatic dressing in dacryocystorhinostomy," Ophthalmic Plastic and Reconstructive Surgery (Vol: 25, Issue: 5, Page 350-353) - 2009

"Conjunctivodacryocystorhinostomy with the frosted jones pyrex tube," Ophthalmic Plastic and Reconstructive Surgery (Vol: 25, Issue: 1, Page 42-43) - 2009

"MÃ¼ller muscle-conjunctiva resection to correct ptosis in high-risk patients," Ophthalmic Plastic and Reconstructive Surgery (Vol: 23, Issue: 5, Page 363-366) - 2007

"Frosted Jones Pyrex tubes," Ophthalmic Plastic and Reconstructive Surgery (Vol: 21, Issue: 3, Page 185-187) - 2005

"Surgical technique: Treatment of multiple apocrine hidrocystomas with trichloroacetic acid," Ophthalmic Plastic and Reconstructive Surgery (Vol: 21, Issue: 2, Page 148-150) - 2005

"Characteristics and outcomes of strabismus surgery after orbital decompression for thyroid eye disease," Journal of AAPOS (Vol: 9, Issue: 1, Page 26-30) - 2005

"Re: Gold weight implantation: A better way? [1] (multiple letters)," Ophthalmic Plastic and Reconstructive Surgery (Vol: 21, Issue: 1, Page 80-) - 2005

"Customized, single-incision, three-wall orbital decompression," Ophthalmic Plastic and Reconstructive Surgery (Vol: 21, Issue: 1, Page 1-9) - 2005

"Endoscopic pretrichial brow lift: Surgical indications, technique and outcomes," Ophthalmic Plastic and Reconstructive Surgery (Vol: 20, Issue: 4, Page 268-273) - 2004

"Gold weight implantation: A better way?," Ophthalmic Plastic and Reconstructive Surgery (Vol: 20, Issue: 3, Page 202-206) - 2004

"Orbital and periorbital myofibromas in childhood: Two case reports," Ophthalmology (Vol: 110, Issue: 10, Page 2000-2005) - 2003

"Current treatments for brow ptosis," Current Opinion in Ophthalmology (Vol: 14, Issue: 5, Page 260-266) - 2003

"Infection after blepharoplasty with and without carbon dioxide laser resurfacing," Ophthalmology (Vol: 110, Issue: 7, Page 1430-1432) - 2003

"Re: Endoscopic subperiosteal midface lift - Surgical technique with indications and outcomes [1] (multiple letters)," Ophthalmic Plastic and Reconstructive Surgery (Vol: 19, Issue: 3, Page 252-) - 2003

"Re: "MÃ¼ller muscle-conjunctival resection: Effect on tear production" [3] (multiple letters)," Ophthalmic Plastic and Reconstructive Surgery (Vol: 19, Issue: 3, Page 254-255) - 2003