OHSU

Stephen A. Back, M.D., Ph.D.

Head Shot of Stephen Back

Background

The Back Lab focuses on the development of novel strategies to promote regeneration and repair of injury to the developing brain. The lab studies mechanisms by which hypoxia-ischemia triggers cerebral white matter injury, the major cause of cerebral palsy (CP) in survivors of preterm birth. We focus on the oligodendrocyte lineage, as well as several other key cellular components of the white matter. We use several complementary approaches that employ human tissues, tissue culture systems and unique animal models. We also extend these developmental observations to define mechanisms of white matter injury in adult CNS in disorders that include multiple sclerosis and Alzheimer's Disease.


Selected Publications

"Digestion products of the PH20 hyaluronidase inhibit remyelination," Annals of Neurology (Vol: 73, Issue: 2, Page 266-280) - 2013

"Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization," Science Translational Medicine (Vol: 5, Issue: 168, Page 168ra7) - 2013

"Human neural stem cells induce functional myelination in mice with severe dysmyelination (Science Translational Medicine (2012) 4, (165er7))," Science Translational Medicine (Vol: 4, Issue: 165, Page ) - 2012

"Central axons preparing to myelinate are highly sensitivity to ischemic injury," Annals of Neurology (Vol: 72, Issue: 6, Page 936-951) - 2012

"Human neural stem cells induce functional myelination in mice with severe dysmyelination," Science Translational Medicine (Vol: 4, Issue: 155, Page ) - 2012

 

OHSU Doernbecher Children's Hospital

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503 346-0640

Memberships & Associations

Neurology (with special certification in Child Neurology), 1997