Robert Searles, Ph.D. Publications
Schimerlik, M.I. and Searles, R.P. 1980. Ligand interactions with membrane-bound porcine atrial muscarinic receptors. Biochemistry 19:3407-3413.
Westcott, K.R., Searles, R.P., and Rome, L.R. 1987. Evidence for ligand- and pH-dependent conformational changes in liposome-associated mannose 6-phosphate receptors. J. Biol. Chem. 262:6106-6107.
Machida, C.A., Bunzow, J.R., Searles, R.P., Van Tol, H., Tester, B., Neve, K.A., Teal, P., Nipper, V., and Civelli, O. 1990. Molecular cloning and expression of the rat ?1-adrenergic receptor gene. J. Biol. Chem. 265:7920-7924.
Young, S.L., Searles, R.P., Kaynard, A.H., and Melner, M.H. 1991. Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter. J. Biol. Chem. 266:15839-15844.
Searles, R.P., Midson, C.N., Nipper, V.J., and Machida, C.A. 1995. Transcription of the rat ?1-adrenergic receptor gene: Characterization of the transcript and identification of important sequence elements. J. Biol. Chem. 270:157-162.
Mantey, S.A., Weber, H.C., Sainz, E., Akeson, M., Ryan, R.R., Pradhan, T.K., Searles, R.P., Spindel, E.R., Battey, J.F., Coy, D.H., Jensen, R.T. 1997. Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J. Biol. Chem. 272:26062-26071.
Machida, C.A., Searles, R.P., Nipper, V., Brown, J.A., Kozell, L.B., and Neve, K.A. 1992. Molecular cloning and expression of the rhesus macaque D1 dopamine receptor gene. Mol. Pharmacol. 41:652-659.
Kickhoefer, V.K., Searles, R.P., Kedersha, N.L., Garber, M.E, Johnson, D.L.., and Rome, L.H. 1993. Vault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase II. J. Biol. Chem. 268:7868-7873.
Searles, R.P., Nipper, V., and Machida, C.A., 1994. The rhesus macaque ß1-adrenergic receptor gene: Structure of the gene and comparison of the flanking sequences with the rat ß1-adrenergic receptor gene. DNA Sequence 4:231-241.
Searles, R.P., Bergquam, E.P., Axthelm, M.K., Wong, S.W., 1999. Sequence and genomic analysis of a rhesus macaque rhadinovirus with similarity to Kaposi’s sarcoma-associated herpevirus/human herpesvirus 8. J. Virol. 73:3050-3053.
Reddy, P.H., McWeeney, S., Park, B.S., Manczak, M., Gutala, R., Partovi, D., Jung, J., Yau, V., Searles, R., Mori, M. and Quinn, J. 2004. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum. Mol. Genet. 13, 1225-1240.
Fang, Y., Choi, D., Searles, R.P., and Mathers, W.D. 2005. A time course microarray study of gene expression in the mouse lacrimal gland after acute corneal trauma. Invest Ophthalmol Vis Sci 46,461-9.
Xu, J., Stouffer, R.L., Searles, R.P., and Hennebold, J.D. 2005. Discovery of LH-regulated genes in the primate corpus luteum. Mol Hum Reprod. 11,151-159.
Streblow, D. N., van Cleef, K.W.R., Kreklywich, C.N., Meyer, C., Smith, P., Defilippis, V., Grey, F., Früh, K., Searles, R., Bruggeman, C, Vink, C., Nelson, J.A., and Orloff, S.L. 2007. Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J. Virol. 81,3816-3826.
Fish, D.J., Horne, T.M., Searles, R.P., Brewood, G.P., and Benight, A.S. 2007. Mulitplex SNP Discrimination. Biophys. J., 92, L89-L91.
Fish, D.J., Horne, T.M., Brewood, G.P., Goodarzi, J.P., Alemayehu, S., Bhandiwad, A., Searles, R.P., and Benight, A.S. 2007. DNA multiplex hybridization on microarrays and thermodynamic stability in solution: a direct comparison. Nucleic Acids Res. 35, 7197.
Orzechowska, B.U., Powers, M.F., Sprague, J., Li, H., Yen, B., Searles, R.P., Axthelm, M.K., and Wong, S.W. 2008. Rhesus macaque rhadinovirus-associated non-Hodgkin’s lymphoma: animal models for KSHV associated malignancies. Blood, 112, 4227.
Walter, N.A.R., Bottomly, D., Laderas, T., Mooney, M.A., Darakjian, P., Searles, R.P., Harrington, C.A., McWeeney, S.K., HItzemann, R., and Buck, K. J. 2009. High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs. BMC Genomics 10:379.
Book Chapters
Searles, R.P., 2003. Arrays for the Masses – Setting Up A Microarray Core Facility; in A Beginner’s Guide to Microarrays, Eric Blalock, ed. Pp. 123-150. Kluwer Academic Publishers, Boston/Dordrecht/London.
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