OHSU

Publications

Learn more about uses of ICP-MS and research by Core Users and by our lab


2013

Vogt S, Ralle M. Opportunities in multidimensional trace metal imaging: taking copper-associated disease research to the next level. Anal Bioanal Chem. 2013 Feb;405(6):1809-20. doi: 10.1007/s00216-012-6437-1. Epub 2012 Oct 19. PubMed Link for this Article

 

2012

Gray LW, Peng F, Molloy SA, Pendyala VS, Muchenditsi A, Muzik O, Lee J, Kaplan JH, Lutsenko S. Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load. PLoS One. 2012;7(6):e38327. doi: 10.1371/journal.pone.0038327. Epub 2012 Jun 22.  PubMed Link for this Article
Vyleta ML, Wong J, Magun BE. Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome. PLoS One. 2012;7(5):e36044. doi: 10.1371/journal.pone.0036044. Epub 2012 May 14. PubMed Link for this Article
Gaier ED, Kleppinger A, Ralle M, Mains RE, Kenny AM, Eipper BA. High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics. Exp Gerontol. 2012 Jul;47(7):491-6. doi: 10.1016/j.exger.2012.03.014. Epub 2012 Mar 29. PubMed Link for this Article
Yeh S, Ralle M, Phan IT, Francis PJ, Rosenbaum JT, Flaxel CJ. Occult intraocular foreign body masquerading as panuveitis: inductively coupled mass spectrometry and electrophysiologic analysis. J Ophthalmic Inflamm Infect. 2012 Jun;2(2):99-103. doi: 10.1007/s12348-011-0035-9. Epub 2011 Jul 31. PubMed Link for this Article


2011

Burkhead JL, Ralle M, Wilmarth P, David L, Lutsenko S. Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease. J Mol Biol. 2011 Feb 11;406(1):44-58. doi: 10.1016/j.jmb.2010.12.001. Epub 2010 Dec 10. PubMed Link for this Article
Quinn JF, Harris C, Kaye JA, Lind B, Carter R, Anekonda T, Ralle M. Gender effects on plasma and brain copper. Int J Alzheimers Dis. 2011;2011:150916. doi: 10.4061/2011/150916. Epub 2011 Oct 19. PubMed Link for the Article
Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF. Phytic acid as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35. doi: 10.3233/JAD-2010-101287. PubMed Link for this Article


2010

Ralle M, Huster D, Vogt S, Schirrmeister W, Burkhead JL, Capps TR, Gray L, Lai B, Maryon E, Lutsenko S. Wilson disease at a single cell level: intracellular copper trafficking activates compartment-specific responses in hepatocytes. J Biol Chem. 2010 Oct 1;285(40):30875-83. doi: 10.1074/jbc.M110.114447. Epub 2010 Jul 20. PubMed Link for this Article
LeShane ES, Shinde U, Walker JM, Barry AN, Blackburn NJ, Ralle M, Lutsenko S. Interactions between copper-binding sites determine the redox status and conformation of the regulatory N-terminal domain of ATP7B. J Biol Chem. 2010 Feb 26;285(9):6327-36. doi: 10.1074/jbc.M109.074633. Epub 2009 Dec 23. PubMed Link for this Article
Quinn JF, Harris CJ, Cobb KE, Domes C, Ralle M, Brewer G, Wadsworth TL. A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;21(3):903-14. doi: 10.3233/JAD-2010-100408. PubMed Link for this Article


2009

Bartee MY, Ralle M, Lutsenko S. The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k. PubMed Link for this Article
Ralle M, Lutsenko S. Quantitative imaging of metals in tissues. Biometals. 2009 Feb;22(1):197-205. doi: 10.1007/s10534-008-9200-5. Epub 2009 Jan 7. Review. PubMed Link for this Article


2007

Huster D, Purnat TD, Burkhead JL, Ralle M, Fiehn O, Stuckert F, Olson NE, Teupser D, Lutsenko S. High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. J Biol Chem. 2007 Mar 16;282(11):8343-55. Epub 2007 Jan 7. PubMed Link for this Article
Bauman AT, Ralle M, Blackburn NJ. Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor. Protein Expr Purif. 2007 Jan;51(1):34-8. Epub 2006 Jun 27. PubMed Link for this Article


2005

Nakano S, Erwin KN, Ralle M, Zuber P. Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx. Mol Microbiol. 2005 Jan;55(2):498-510. PubMed Link for this Article


2004

Ralle M, Berry SM, Nilges MJ, Gieselman MD, van der Donk WA, Lu Y, Blackburn NJ. The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc. 2004 Jun 16;126(23):7244-56. PubMed Link for this Article
Ralle M, Lutsenko S, Blackburn NJ. Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B): X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal binding domains and their interaction with exogenous ligands. J Inorg Biochem. 2004 May;98(5):765-74. PubMed Link for this Article
Walker JM, Huster D, Ralle M, Morgan CT, Blackburn NJ, Lutsenko S. The N-terminal metal-binding site 2 of the Wilson's Disease Protein plays a key role in the transfer of copper from Atox1. J Biol Chem. 2004 Apr 9;279(15):15376-84. Epub 2004 Jan 30. PubMed Link for this Article


2003

Berry SM, Ralle M, Low DW, Blackburn NJ, Lu Y. Probing the role of axial methionine in the blue copper center of azurin with unnatural amino acids. J Am Chem Soc. 2003 Jul 23;125(29):8760-8. PubMed Link for this Article
Ralle M, Lutsenko S, Blackburn NJ. X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines. J Biol Chem. 2003 Jun 20;278(25):23163-70. Epub 2003 Apr 9. PubMed Link for this Article


2000

Eisses JF, Stasser JP, Ralle M, Kaplan JH, Blackburn NJ. Domains I and III of the human copper chaperone for superoxide dismutase interact via a cysteine-bridged Dicopper(I) cluster. Biochemistry. 2000 Jun 27;39(25):7337-42. PubMed Link for this Article
Blackburn NJ, Rhames FC, Ralle M, Jaron S. Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase: implications for electron transfer and the catalytic mechanism. J Biol Inorg Chem. 2000 Jun;5(3):341-53. PubMed Link for this Article
Blackburn NJ, Ralle M, Hassett R, Kosman DJ. Spectroscopic analysis of the trinuclear cluster in the Fet3 protein from yeast, a multinuclear copper oxidase. Biochemistry. 2000 Mar 7;39(9):2316-24. PubMed Link for this Article


1999

Ralle M, Verkhovskaya ML, Morgan JE, Verkhovsky MI, Wikström M, Blackburn NJ. Coordination of CuB in reduced and CO-liganded states of cytochrome bo3 from Escherichia coli. Is chloride ion a cofactor? Biochemistry. 1999 Jun 1;38(22):7185-94. PubMed Link for this Article
Blackburn NJ, Ralle M, Gomez E, Hill MG, Pastuszyn A, Sanders D, Fee JA. Selenomethionine-substituted Thermus thermophilus cytochrome ba3: characterization of the CuA site by Se and Cu K-EXAFS. Biochemistry. 1999 Jun 1;38(22):7075-84. PubMed Link for this Article