The Vollum comprises a vibrant and diverse scientific community focused on understanding fundamental biological mechanisms. Learn about our faculty & labs
Welcome to the Vollum Institute
The Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, have provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease.
Eric Gouaux, senior scientist at the Vollum Institute and Howard Hughes Medical Investigator, will receive the 2016 Anatrace Membrane Protein Award from the Biophysical Society at their annual meeting in Los Angeles this March. The award recognizes outstanding investigators who make a significant contribution to the field of membrane protein research. Gouaux was selected for his work on the atomic structure of neurotransmitter transporters and ion channels that has revolutionized our understanding of the molecules underlying synaptic transmission in the brain.
Learn more about Eric Gouaux's research
Balakrishnan et al. reveal the properties of graded and sustained exocytosis at small inhibitory interneurons in the retina. These neurons are some of first to be damaged by diabetic retinopathy. Studies of new neuro-protective drugs using prediabetic animals will now become more focused.
Read the full article on the OHSU Research News Blog
Depression of serotonin synaptic transmission by the dopamine precursor L-DOPA.
Stephanie C. Gantz, Erica S. Levitt, Nerea Llamosas, Kim A. Neve, John T. Williams
Cell Reports, 2015 Aug 11;12(6):944-954
Synaptic vesicle exocytosis at the dendritic lobules of an inhibitory interneuron in the mammalian retina.
Veeramuthu Balakrishnan, Theresa Puthussery, Mean-Hwan Kim, W. Rowland Taylor, Henrique von Gersdorff
Neuron, 2015 Aug 5;87(3):563-575
miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1–Lhx3.
Karen P. Thiebes, Heejin Nam, Xiaolu A. Cambronne, Rongkun Shen, Stacey M. Glasgow, Hyong-Ho Cho, Ji-sun Kwon, Richard H. Goodman, Jae W. Lee, Seunghee Lee, Soo-Kyung Lee
Nature Communications, 2015 July 27;6(7718)
Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Kevin H. Wang, Aravind Penmatsa, Eric Gouaux
Nature, 2015 May 21;521(7552):322-327