Welcome

The Vollum Institute at OHSUThe Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, have provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease.

Learn more about the Vollum's mission

Recent Publications

Cholinergic interneurons underlie spontaneous dopamine release in nucleus accumbens
Jordan T. Yorgason, Douglas M. Zeppenfeld and John T. Williams
The Journal of Neuroscience, 2017 Feb 22; 37(8):2086-2096

A gradient in synaptic strength and plasticity among motoneurons provides a peripheral mechanism for locomotor control
Wei-Chun Wang and Paul Brehm
Current Biology, 2017 Feb 6; 27(3):415-422

Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP
Maho Takahashi, Yanping Li, Tara J. Dillon and Philip J.S. Stork
The Journal of Biological Chemistry, 2017 Jan 27; 292(4):1449-1461

Recent News

Dr. Gail Mandel was recently elected as a councilor for Society for Neuroscience by their membership. Her term will begin this fall at the NSF annual meeting.
Learn more in OHSU Research News

NMDA receptors (NMDAR) play a central role in chemical neurotransmission where the prevalent receptor assembly has two identical glycine-binding subunits and two distinct glutamate binding subunits. To determine how the incorporation of two different GluN2 subunits alters receptor symmetry and subunit-subunit interactions, scientists in the Gouaux Lab resolved the structure of the GluN1/GluN2A/GluN2B receptor by single particle cryo-EM. The lab's research revealing the architecture of the triheteromeric NMDA receptor complex was published online Feb. 23 in the journal Science.
Read the abstract in PubMed

A team of scientists, led by Marc Freeman at the Vollum Institute and Mary Logan at the Jungers Center for Neurosciences Research, recently identified a gene, TRAF4, which provides important information about the signaling pathways that spur glial cells to recognize and clear degenerating axons. The research was published online Feb. 6 in the journal Nature Communications. Co-authors include Tsai-Yi Lu at Johns Hopkins University and Jennifer MacDonald, Lukas Neukomm, Amy Sheehan and Rachel Bradshaw from the University of Massachusetts Medical School.
Learn more in OHSU Research News
Read the abstract in PubMed