Welcome to the Vollum InstituteThe Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, have provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease.
Researchers in Eric Gouaux's lab have discovered new information about the structure of the N-methyl-D-aspartate (NMDA) receptor, a brain receptor that is crucial for learning and memory. Lab members—Chia-Hsueh Lee, Wei Lü, Jennifer Michel, April Goehring, Juan Du and Xianqiang Song—created a 3-D model which reveals key structural details about the receptor's subunit arrangement and pore architecture.
Read the OHSU press release
Read the abstract in PubMed
Senior Scientist, John Adelman, received the 2014 Richard T. Jones Distinguished Alumni Scientist Award. This award is presented by OHSU's School of Medicine Alumni Association and recognizes continuing research excellence and contributions to both the scientific community and basic science education.
Watch Dr. Adelman's interview on YouTube (starts around 03:54)
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
Katharina L. Dürr*, Lei Chen*, Richard A. Stein, Rita De Zorzi, I. Mihaela Folea, Thomas Walz, Hassane S. Mchaourab, and Eric Gouaux (*co-first author)
Cell online, August 7
X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism.
Lei Chen, Katharina L. Dürr, and Eric Gouaux
Science online, August 7
A comprehensive thalamocortical projection map at the mesoscopic level.
Barbara J. Hunnicutt, Brian R. Long, Deniz Kusefoglu, Katrina J. Gertz, Haining Zhong, and Tianyi Mao
Nature Neuroscience online, August 3
Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus.
Pierre F. Apostolides and Laurence O. Trussell
Neuron, July 16; 83(2):324-330
NMDA receptor structures reveal subunit arrangement and pore architecture.
Chia-Hsueh Lee, Wei Lü, Jennifer Carlisle Michel, April Goehring, Juan Du, Xianqiang Song, and Eric Gouaux
Nature, July 10; 511:191-197
Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal.
Aya Matsui, Brooke C. Jarvie, Brooks G. Robinson, Shane T. Hentges, and John T. Williams
Neuron, June 18; 82(6):1345-1356
A Walk Through a Vollum Lab
Gary Westbrook created a three-minute video to explain the research being conducted in his lab. The video is targeted to prospective postdoctoral fellows and students.