Nicolson Lab
Associate Professor, Oregon Hearing Research Center
and HHMI Investigator: Teresa Nicolson
We are interested in the molecular basis of mechanotransduction and synaptic transmission in auditory/vestibular hair cells. To identify key players in these processes, we are studying zebrafish mutants with hearing and balance defects. The aim of our research is to determine gene function by examining the mutants at multiple levels, including the behavioral, cellular, and physiological levels. Another major goal is to provide animal models of human deafness.
Recently, we have concentrated our efforts on developing innovative ways of characterizing our mutants. These new techniques include quantitation of the vestibulo-ocular reflex, measuring post-synaptic responses to mechanical stimulation of hair cells, and calcium imaging of hair-cell transients using localized genetic indicators. With these tools in hand, we are able to gain a better understanding of gene function and apply our findings to understanding the pathology of congenital deafness in humans.
CURRENT LAB MEMBERS
- Teresa Nicolson
Primary Investigator
- Greta Glover
Postdoctoral Fellow
- Katie Kindt
Postdoctoral Fellow
- Lavinia Sheets
Postdoctoral Fellow
- Josef Trapani
Postdoctoral Fellow
- Zev Einhorn
Graduate Student
- Weike Mo
Graduate Student
- Gabe Finch
Research Staff
- Sireesha Govada
Research Staff
- Norm Edelen
Fish Facility Staff
- Lisa Hayashi
Fish Facility Staff
- Lieu Than
Technical Staff
NICOLSON LAB 2009
Front row: Rachel Clemens-Grisham, Lieu Than, Lavinia Sheets, Katie Kindt Middle row: Joe Trapani, Sireesha Govada, Greta Glover, Norm Edelen, Teresa Nicolson, Lisa Hayashi Back row: Zev Einhorn, Weike Mo, Gabe Finch
EMPLOYMENT OPPORTUNITIES
Postdoctoral Fellow
Postdoctoral positions are usually available in the Nicolson lab for qualified PhDs. A background in cell biology, neuroscience, physiology, or genetics is ideal. If interested, please send your CV and names of three references to Teresa Nicolson via email.
Graduate Student Program
Graduate students can enter the Nicolson lab via the Neuroscience Graduate Program or the Program in Molecular and Cellular Bioscience.
Summer Research Opportunities
Every summer, we have a few stipend-supported positions for undergraduates. If interested, contact Teresa Nicolson via email.
