Barr-Gillespie Lab

Professor of Otolaryngology, Joint Appointment: Peter Barr-Gillespie

Barr-Gillespie Lab Home | Projects | Members | Resources

 

Barr-Gillespie Lab: image of single hair cellThe Barr-Gillespie Lab studies mechano-electrical transduction by hair cells, the sensory cells of the inner ear. We are particularly interested in the molecules that make up the transduction apparatus. Visit our Projects page to find out more about ongoing research in the lab.

 

One Recent Discovery in the Lab

gillespielab_harmoninIn collaboration with Uli Mueller's laboratory, we have found that the scaffolding protein harmonin is present at the upper tip-link density in hair cells, a location critical for the regulation of mechanotransduction (Grillet et al., 2009). In this image, a bullfrog hair cell is labeled with phalloidin to highlight actin (red) and an anti-harmonin antibody (green). Harmonin is located in discrete clusters near stereocilia tips. We are presently investigating interaction of harmonin, the tip-link protein cadherin 23, and the adaptation motor myosin-1c.

Lab Phone Number:
(503) 494-2950

MAILING ADDRESS

Peter Barr-Gillespie Lab
Oregon Health & Science University
Mail Code L335A
3181 SW Sam Jackson Park Rd.
Portland, OR 97239

 

SHIPPING ADDRESS

Peter Barr-Gillespie Lab
Oregon Health & Science University
Dock 4, MRB 920
3181 SW Sam Jackson Park Rd.
Portland, OR 97239