Professor of Otolaryngology,
Joint Appointment: Peter Barr-Gillespie
The Barr-Gillespie Lab studies mechano-electrical transduction by hair cells, the sensory cells of the inner ear. We are particularly interested in the molecules that make up the transduction apparatus. Visit our Projects page to find out more about ongoing research in the lab.
In collaboration with Uli Mueller's laboratory, we have found that the scaffolding protein harmonin is present at the upper tip-link density in hair cells, a location critical for the regulation of mechanotransduction (Grillet et al., 2009). In this image, a bullfrog hair cell is labeled with phalloidin to highlight actin (red) and an anti-harmonin antibody (green). Harmonin is located in discrete clusters near stereocilia tips. We are presently investigating interaction of harmonin, the tip-link protein cadherin 23, and the adaptation motor myosin-1c.
Postdoctoral positions are usually available in the Barr-Gillespie lab for qualified PhDs. A background in cell biology, neuroscience, physiology, or biochemistry is ideal. If interested, please send your CV and names of three references to Peter Barr-Gillespie via email.
Summer Research Opportunities
Every summer, we have a few stipend-supported positions for undergraduates. If interested, contact Peter Barr-Gillespie via email.