This section lists faculty, postdoctoral, research, and administrative positions available in the Vollum Institute at OHSU.
Employment at the Vollum often allows sufficient time for career-enhancing activities, such as attendance at seminars and participation in lab meetings. Many technicians go on to graduate training at OHSU and other top programs. Long term employment opportunities including some with supervisory responsibilities are also available in some laboratories.
OHSU is an equal opportunity affirmative action institution.
The Vollum Institute (www.ohsu.edu/vollum) junior faculty search for 2013–14 has closed. For more information, contact:
Larry Trussell, Ph.D.
Vollum Institute, L-335A
Oregon Health & Science University
3181 SW Sam Jackson Park Road
Portland, OR 97239-3098
For information about postdoctoral positions not listed here, please contact individual faculty members for the particular lab(s) in which you are interested.
Gail Mandel Lab
Postdoctoral Research Associate positions are open for complementary studies on the roles of REST during neuronal maturation and glial-neuronal interactions involved in maintaining central nervous system circuitry. The REST repressor protein is a unique regulator of neuronal gene chromatin and we are studying how it changes higher order chromatin architecture and gene expression in individual neurons during aging. We have also launched studies of gene regulation in human neural cells. The Mandel lab is a leader in the study of mouse models for neurological diseases, such as autism spectrum disorders. We recently identified glia as integral components of mature brain circuitry that are affected in neurological disease and are using imaging and electrophysiology, in conjunction with genetics, to pinpoint the defects.
The lab is located in the Vollum Institute at Oregon Health & Science University in Portland. Interested candidates within 4 years of having received their PhD are encouraged to apply. Prior expertise in molecular and cellular biology, or biochemistry, is essential.
To apply, please email CV and contact details of three references to firstname.lastname@example.org.
Teresa Nicolson Lab
The Nicolson lab studies the development and function of sensory hair cells in zebrafish. Through forward and reverse genetic approaches, we have identified many genes that are required for mechanotransduction (tmc1/2, cdh23, pcdh15a, myo7a, tmie, myo6b, tmhs, and tomt) and synaptic transmission (ribeye, cav1.3a, rbc3a, vglut3, synj1). The majority of these genes are implicated in human deafness and the zebrafish is an excellent alternative model for auditory/vestibular dysfunction.
We use many different types of methods to analyze genes and mutant phenotypes in embryonic and larval zebrafish. Our work involves analyses at the molecular, genetic, cellular, physiological, and behavioral levels. Applicants with expertise in using a genetic model system such as flies, mice or zebrafish will be considered. Expertise in molecular biology and histology is helpful. In addition, it would be very advantageous (but not required) if the applicant has experience with calcium imaging or electrophysiology.
The position is immediately available. Please send a cover letter indicating your interest in a particular aspect of our work, along with your CV and the email addresses of three references. A track record of solid publications and productivity is important for serious consideration.
Please email documents to: email@example.com.
Soo Lee Lab
Gene Networks in CNS Development
Unraveling the processes that generate the numerous neuronal subtypes and establish their appropriate connections to form a functional CNS is one of the main challenges in neuroscience today. Particularly, decoding the gene regulatory network responsible for neuronal subtype specification is a fundamental step toward understanding the CNS development and advancing methods to generate specific neurons in regenerative medicine.
Our goal is to develop a comprehensive map of the complex gene regulatory networks that direct cell-fate specification and assembly of neuro-circuits. Our major model systems include the spinal cord, which consists of distinct classes of neurons to assemble motor and sensory circuits.
To achieve our goals, we dissect multiple layers of gene regulatory steps that render neuronal cell-fate specification, taking the following steps; to define transcription complexes specifying each neuronal population, to identify their downstream effector genes conferring unique cell-identity, to understand epigenetic strategy orchestrating timely changes on gene transcription, to uncover the molecular mechanism by which the extracellular cues modulate neuronal gene expression, and to generate specific neuronal subtypes from stem cells by applying the developmental gene regulatory strategy that we define. Our study will eventually contribute to the design of a rational strategy to repair damaged neurons and to treat metabolic disorders in the human.
Dev 138:2823-2832, 2011; Curr Opin Neurobiol 20:29-36; Neuron 61:839-851, 2009; Neuron 62:641-654, 2009; Dev Cell 14: 877-89, 2008; Genes Dev 21: 744-9, 2007; Science 307: 596-600, 2005; Neuron 38: 731-745, 2003; Cell 110: 237-249, 2002.
For further details, please visit Soo Lee's lab page.
If you are interested in a position in our lab, please contact Soo Lee directly at firstname.lastname@example.org.
For information about research staff positions not listed here, please contact individual faculty members for the particular lab(s) in which you are interested.
There are no openings at this time.
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