Michael Rutten, Ph.D.
Cell Isolation & Culture, Intracellular Signalling, Immunofluorescence, Confocal Microscopy
Dr. Michael Rutten is involved in studies in the isolation, characterization and culture of adult stem cells and cell lines for their use in cell therapy. Dr. Rutten is currently working with Dr. Cynthia Gregory on research using allogeneic mesenchymal stromal cells to treat lung disease. He is also an integral part of the Nerve Regeneration, Cardiac Regeneration and Limb regeneration programs, where his background in cell therapy plays a central role. Dr. Rutten specializes in ECIS (Electric Cell-substrate Impedance Sensing) technology, which is being used for stem cell functionality/potency assays in defining the quality of the cell isolations. The goal of this work would be to use this technology for clinical regenerative medicine studies as well as for high-throughput-testing (HTS) of radiation or drugs on stem cells as a diagnostic tool for the clinic or pharmaceutical industry. Other studies he is involved with include the development of functional Schwann-like cells from autologous bone marrow cells with the intention of using them in pre-clinical studies for the treatment of damaged peripheral nerves.
He has previously held positions at the University of Kansas Medical Center, the Portland VA Medical Center/OHSU and the Oregon Medical Laser Center at Providence St. Vincent Medical Center. Dr. Rutten received his PhD degree from the University of California, Berkeley, with a Postdoctoral Fellowship at UCLA, and a Research Fellowship at Harvard Medical School. Dr. Rutten's background includes training in primary cell isolation and culture techniques, intracellular pH and calcium signaling, membrane ion transport, and immunofluorescence and confocal microscopy.