OHSU

Aging NHP Resource

The number of elderly in the U.S. and in other industrialized nations is projected to grow rapidly, perhaps doubling within the next 25 years.  Fueled in part by the expansive baby-boom generation, coupled with increased lifespan, record numbers of post-retirees will enjoy a longer period of time in their "golden years".  But, as the leading edge of this population cohort has already entered retirement, it is also anticipated that there will also be a concomitant escalation in the number of elderly who experience increased fragility and chronic, progressive illnesses.  This gradual loss of "functional lifespan" will be a broad challenge for health care management, social services, and entitlement programs.

The National Institute on Aging (NIA) was created by Congress in 1974, to meet the emerging aging challenge, with a focus on the extension of the "health-span" of people.  In order to accelerate research on aging and its diseases, the NIA helped create models for human aging, including the Primate Aging Study (PAS).  The PAS program has provided support for the formation and maintenance of colonies of aged nonhuman primates at ONPRC, as well as other participating Primate Centers.  The PAS colonies take advantage of the existing resources at the NPRCs to produce and maintain this vital research model.

To enhance aging research at ONPRC, the Aging Nonhuman Primates Resource was created in 1999, with the following programmatic goals:

Manage the enrollment of animals into the PAS program.
Provide enhanced husbandry and veterinary care for aged primates.

  • Provide technical and veterinary consultation to for research efforts.
  • Coordinate animal assignments to research projects.
  • Promote collaborative efforts in basic and clinical science.
  • Perform longitudinal, non-invasive exams, such as the collection of biomarkers of aging and in vivo scans.
  • Support the development of projects, which contribute to translation research.
The Aging Resource currently supports several projects that span several disciplines and includes the examination of the effects of aging on central nervous system function (for example, cognition), reproductive senescence and immune function.  In addition, projects on models of neurodegeneration are also currently being pursued.  Interventions, like diet (restriction and other modulations) and hormone-replacement therapy have also been utilized and variations of these and other experimental themes continue to evolve.

 

The Aging Nonhuman Primates Resource also provides the foundation for the Biology of Aging Program.  This research focus group was recently generated due to wide interest in aging by the researchers at ONPRC and OHSU, and will help create a multi-disciplinary approach in the study of senescence in the nonhuman primate.

Steven G. Kohama, Ph.D., Senior Staff Scientist, Head