Special Resource Programs
The purpose of the Special Resource Programs is to ensure that the animal needs of the various research programs are met. The current programs are Aging Nonhuman Primates, Obese Nonhuman Primates and Japanese Macaque Resource.
The Aging Nonhuman Primate Resource provides animals necessary for research on the mechanisms of aging and age-related diseases, and is an important component of the Biology of Aging Program at the ONPRC and OHSU Healthy Aging Alliance. This unique, highly translational resource is supported by ONPRC and also the National Institute on Aging (NIA), the latter through the Primate Aging Study program. The NIA recognized the need for a highly translatable model, similar to humans, to address the health concerns of the growing elderly population. Already the oldest baby-boomers have entered retirement, and accompanying the continued escalation in the number of post-retirees, will be a transition of individuals into greater levels of fragility and chronic, progressive illnesses. Hence any therapies that can delay, diminish, and in some cases, cure maladies that are associated with advanced age, will be essential to mitigate health concerns in the elderly.
The Obese Nonhuman Primate Resource is comprised of three colonies of macaques that become obese when fed a high-fat/high-calorie diet (HF diet). The Japanese macaque model supports investigations on the effects of maternal diet and metabolic health on the development of metabolic systems in the offspring; the Rhesus macaque model is employed for studies testing pharmaceutical therapeutics for obesity, insulin resistance, and cardiovascular disease; and the Cynomolgous macaque model supports research models that investigate metabolic disease in nonhuman primates. All three models are used for research in the Metabolic Disease Working Group. These models are being expanded in an effort to understand the progression of the disease as well as to understand the full spectrum of complications that are associated with obesity.