Dr. Matsumoto's research interest is in the field of developmental neurobiology. He began his research career studying the mechanisms controlling the development of invertebrate sensory systems. This work challenged the prevailing view that the development of "simple" invertebrate nervous systems were predetermined (hardwired). Later, he moved on to the study of how neurotransmitter phenotype was determined in peripheral autonomic neurons. This demonstrated that individual sympathetic neurons could change their neurotransmitter phenotype from noradrenergic to cholinergic, under the influence of a soluble, target-derived factor. Following this interest, he began studies on the differentiation of peripheral neurons from their embryonic progenitor population, the neural crest. These studies led to their discovery that specific arrays of high voltage-activated calcium channels could be used to identify sympathetic and sensory neurons differentiating in cultures of neural crest cells.
In 2006, Steven began collaborating with Larry Sherman and his laboratory. Together, they have identified a novel role for chromatin remodeling factors in the cell fate determination in the mammalian cortex. They have also begun to study the role in regulating sensory neuronal phenotype in the peripheral nervous system.
Steven Matsumoto is an Associate Professor in the Department of Integrative Biosciences of the Dental School and a collaborator of Larry Sherman in the Division of Neuroscience since 2006. He received his BS in Zoology from the University of Washington in 1972, and a PhD in Neuroscience from the State University of New York, Albany in 1976. From 1976-1986, he worked in two different laboratories in the Department of Neurobiology at Harvard Medical School, transitioning from studies of invertebrate neurodevelopment to mammalian neurodevelopment. In 1987, he took a position as a Research Assistant Professor in the Departments of Physiology and Pharmacology at the University Arizona before moving to Oregon Health & Science University in 1989.
Matsumoto S, Banine F, Struve J, Xing R, Adams C, Liu Y, Metzger D, Chambon P, Rao MS and Sherman LS. (2006) Brg1 is required for murine neural stem cell maintenance and gliogenesis. Dev Biol 289:372-383.
Carey MB, and Matsumoto SG. (2000) Calcium transient activity in cultured murine neural crest cells is regulated at the IP(3) receptor. Brain Res. 862:201-210.