Christopher Dubay

My primary research interest is in complex genetic diseases (e.g., diabetes, hypertension, etc.) and the dissection of their genetic basis in model systems and eventually humans.  I have concentrated on the use of bioinformatic tools to aid in the scaling up of experiments and analyses required to address the isolation of multiple genetic loci present in complex traits which can be modeled using systems biology. I currently direct the Oregon National Primate Research Center Colony Demographics & Informatics unit, which provides bioinformatic tools and genetics resources to support colony management and investigations of a wide variety of disease models for translational research.

I am interested in developing and evaluating systems for clinical and research genetic analysis laboratories, such as laboratory and genetics information systems, and translating our new biological knowledge into clinical interventions.  I am a founder of Genetic Information Management Systems, and a board member of the personal genomic firm Iverson Genetics.

Biography

Christopher Dubay is an affiliate scientist in the Division of Neuroscience.  He received his Ph.D. in Medical Genetics from Oregon Health & Science University in 1990, followed by post-doctoral work in complex genetics at the Center d'Etude du Polymorphism Humain in Paris, France and the Wellcome Trust Center for Human Genetics at the University of Oxford.  He has done research and teaching as an assistant professor in OHSU's departments of Molecular Medical Genetics and Medical Informatics & Clinical Epidemiology. 

Key Publications

Dubay C, Vincent M, Samani NJ, Hilbert P, Kaiser MA, Beressi JP, Kotelevtsev Y, Beckmann JS, Soubrier F, Sassard J, and Lathrop GM. (1993) Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.  Nature Genetics 3:354-357. PMID:7981757.

Dubay C, Brundege JM, Hersh W, and Spackman K. (2002) Delivering Bioinformatics Training Bridging the Gaps Between Computer Science and Biomedicine. Proc AMIA Symp.  J AM Med Informatics Assoc supp 2002:220-224. PMID:12463819.

Ferguson B, Street SL, Wright H, Pearson C, Jia Y, Thompson SL, ALlibone P, Duban CJ, Spindel E, and Norgren RB Jr. (2007) Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chineses-origin rhesus macaques (Macaca mulatta).  BMC Genomics 8:43. PMID:17286860.

Roth CL, Mastronardi C, Lomniczi A, Wright H,Cabrera R, Mungenast AE, Heger S, Jung H, Dubay C, and Ojeda SR.  (2007) Expression of a tumor related gene network increases in the mammalian hypothalamus at the time of femal puberty.  Endocrinology 148:5147-5161. PMID:17615149.

Khouangsathiene S, Pearson C, Street S, Ferguson B, and Dubay C. (2008) Monkey SNP:  a web portal for non-human primate single nucleotide polymorphisms.  Bioinformatics 24:2645-2646. PMID:18796476.