OHSU

Anda Cornea

Microscopy, one of the oldest tools in biomedical research, has seen tremendous progress in recent years.  New techniques go beyond visualization to derive quantitative information about biological structure and function to investigate physiological processes at the cellular and molecular level.  

Anda Cornea brings to the Primate Center, and to the Division of Neuroscience in particular, the expertise required to develop and implement light microscopy based methods required by all research programs.  She is interested in fluorescence techniques as applied in confocal, deconvolution and two-photon imaging and in laser capture microdissection.  Areas of particular interest include protocol design for quantitative evaluation of imaging experiments, using both stereology and automated image analysis.

 

BIOGRAPHY

 

Anda Cornea is a senior staff scientist in the Division of Neuroscience and head of the Imaging & Morphology Support Core .  She received a BS degree in physics from the University of Bucharest, Romania in 1979 and a PhD in biological sciences from Southern Methodist University in Dallas, TX in 1993.  As a postdoctoral fellow, she studied cellular mechanisms of energy transduction in the HHMI Laboratory of Sensory Neuroscience at Rockefeller University in New York.

 

KEY PUBLICATIONS

 

Jespersen S, Leigland L, Cornea A, Kroenke C. (2011) Determination of Axonal and Dendritic Orientation Distributions within the Developing Cerebral Cortex by Diffusion Tensor Imaging. IEEE Trans Med Imaging. 2011 Jul 14. [Epub ahead of print]

Varlamov O, Somwar R, Cornea A, Kievit P, Grove KL, Roberts CT Jr. (2010) Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes. Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E486-96.

Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, Reddy PH. (2010) Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.  J Alzheimers Dis. 2010;20 Suppl 2:S609-31. 

Janovick JA, Patny A, Mosley R, Goulet MT, Altman MD, Rush TS 3rd, Cornea A, Conn PM. (2009) Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.  Mol Endocrinol. 2009 Feb;23(2):157-68. 

Cornea A, Janovick JA, Maya-Nunez G, and Conn PM. (2001) Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer. J Bio Chem 276:2153-2158.

 

See a full listing of Dr. Cornea's publications.