Anda Cornea

Microscopy, one of the oldest tools in biomedical research, has seen tremendous progress in recent years.  New techniques go beyond visualization to derive quantitative information about biological structure and function, to investigate physiological processes at cellular and molecular level.  

Anda Cornea brings to the Primate Center and to the Division of Neuroscience in particular the expertise required to develop and implement light microscopy based methods required by all research programs.  She is interested in fluorescence techniques as applied in confocal, deconvolution and two-photon imaging and in laser capture microdissection.  Areas of particular interest include protocol design for quantitative evaluation of cimaging experiments using both stereology and automated image analysis.

Biography

Anda Cornea is a senior staff scientist in the Division of Neuroscience and head of the ONPRC Imaging and Medical Illustrations Support Core.  She received a BS degree in physics from the University of Bucharest, Romania in 1979 and a PhD in biological sciences from Southern Methodist University in Dallas, TX in 1993.  As a postdoctoral fellow she studied cellular mechanisms of energy transduction in the HHMI Laboratory of Sensory Neuroscience at Rockefeller University in New York.

Key Publications

Cornea A, Janovick JA, Maya-Nunez G, and Conn PM. (2001) Gonadotropin-releasing hormone receptor microaggregation.  Rate monitored by fluorescence resonance energy transfer.  J Bio Chem 276:2153-2158. PMID:11035030.

Cornea A, and Conn PM. (2002) Measurement of changes in fluorescence resonance energy transfer between gonadotropin-releasing hormone receptors in response to agonists.  Methods  27:333-339.  PMID:12217649.

Gu G, Cornea A, and Simerly RB. (2003) Sexual differentiation of projections from the principal nucleus of the bed nuclei of the stria terminalis. J Comp Neurol 460:542-562. PMID:12717713.

Prevot V, Cornea A, Mungenast A, Smiley G, and Ojeda SR.  (2003) Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor beta1 release via prostaglandin E2 production and induces cell plasticity.  J Neurosci 23:10622-10632. PMID:14627647.