Biostatistics and Bioinformatics Core

Suzi Fei, Ph.D., Core Director, feis@ohsu.edu
Lucia Carbone, Ph.D., Assistant Professor, Scientific Advisor
Byung Park, Ph.D., Associate Professor, Biostatistics
Lina Gao, Ph.D., Associate Biostatistician
Ben Bimber, Ph.D., Research Assistant Professor
Melissa Yan, M.S. Bioinformatics Specialist
Brett Davis, M.S. Bioinformatics Specialist

Biostatistics support covers a range of analyses, including statistical genetics, meta analysis, Bayesian data analysis, longitudinal data analysis, and survival analysis among others. Support for data analysis, study design, and grant/manuscript submission is available. Drop-in sessions are held weekly in order to discuss projects in person. 

Bioinformatics support is offered primarily for the analysis of next-generation sequencing data. Standard analyses include whole genome and exome DNA-seq, variant calling, transcriptome RNA-seq, and pathway analysis. Integration with other data types (e.g. proteomics, metabolomics) as well as other custom analyses can also be performed. The BBC can download data directly from the sequencing facility and store it on OHSU Advanced Computing Center servers. Raw and analyzed data as well as QC reports will be released to the investigator via a secure web server and can be uploaded to a public repository to meet publication requirements. At the end of the project, a final report will be provided to the investigator that will include the methods and analysis results. Throughout the project, the BBC will keep a dialogue with the investigator to make sure that all biological questions are adequately addressed.

Study Design

Project planning and experimental design assistance is provided free of charge. Consultation with the BBC about the study design is highly encouraged and should occur before gathering data in order to determine the correct study design and agree on deliverables. The BBC can also help with randomizing samples in order to minimize biases, such as before sequencing.

Grant Support

The BBC provides the following grant support services free of charge:
1.   Project planning and experimental design assistance. 
2.   Letters of support.
3.   A senior analyst biosketch to add as 'Other Significant Contributor' if desired.
4.   A budget.
5.   A write-up of methods with references.
6.   Review of the biostatistics &bioinformatics sections of the grant.

Please, email Suzi Fei  if you are planning to submit a grant that includes services from the BBC.

Chargebacks

Charges for analysis services, including publication preparation, are $100/hour (of staff time, not compute time). For some projects, we also bill for data storage to cover our costs. For complex or long-term projects, partial FTE support is also available.  

Publications

Authorship is appreciated, especially for projects that involve significant intellectual contribution, time, and/or custom analyses. All publications using our services should include an acknowledgement statement such as:

The authors acknowledge the support of the Oregon National Primate Research Center's Biostatistics &Bioinformatics Core which is funded in part by the center's core grant (NIH/OD P51 OD011092). We specifically acknowledge the assistance of [analyst names and roles].