OHSU

Pharmacokinetic & Pharmacodynamic Studies

Pharmacokinetic (PK) and pharmacodynamic (PD) studies require intensive blood sampling and monitoring. OCTRI nurses are experienced in the intensive requirements of PK/PD studies. Clinical and Translational Research Center staff review the protocol in detail with the investigator and nurses to ensure that the proper data collection, monitoring, and adverse event procedures are in place.

 

Additional Resources

Bioanalytical Shared Resource / Pharmacokinetics Core
The BSR/PK Core is available at OHSU for the analysis of drugs and their metabolites and bio-molecules such as simple peptides, oligonucleotides, carbohydrates, lipids, fatty acids and steroids. The BSR provides open access to a laboratory where users prepare and analyze their own samples by HPLC, GC/MS or LC/MS on equipment maintained by Core personnel.

The BSR/PK Core at OHSU partners with a similar core at Oregon State University (OSU).

OSU Pharmacokinetics Pharmacodynamics Modeling Core
The Oregon State University/OHSU Pharmacokinetics (PK) and Pharmacodynamics (PD) Modeling Core partners with the OHSU Bioanalytical Shared Resources core to conduct PK and PD data analysis and interpretation. The OSU/OHSU PKPD core has the following unique abilities that are currently unavailable at OHSU.

  • The core provides valuable information into the PK study sample design such as number of sampling times and ideal sampling times for a given drug/new molecule, develop a mathematical model to predict biological concentrations of drug/new molecule, and data interpretation.
  • The core is also equipped to handle PK studies in special populations such as pediatrics.
  • The eventual goals of the core is to assist researchers and scientists with tools that would guide optimization of dosing regimen for existing drugs and refine PK studies for further development of drug candidates.