Recent research shows that nearly one third of clinical studies are terminated due to low enrollment.1 You can increase your chances of a successful study with adequate planning in the early stages of protocol development and active recruitment and retention activities during the study. OCTRI has compiled this list of online resources to help assess study feasibility and identify participants.
In addition, the Clinical Trials Office (CTO) at OHSU provides full study start-up services. In the recent underenrollment analysis, only 2% of the studies handled by the CTO had underenrollment compared to other industry studies at OHSU, which had a rate of ~38% during the same time period.
It is important when implementing a study to determine if the study is feasible, both from a recruiting and operational perspective. Below are tools to assist with this analysis.
This online project of the National Cancer Institute has several tools to help evaluate study feasibility. The information on this site is useful for non-cancer studies as well.
Determining how will you find eligible participants Is an important part of the study planning process. The links below will assist you in creating recruitment plans.
A national volunteer research registry that brings together researchers and willing volunteers who wish to get involved in research studies.
Research Data Warehouse
Using Epic data, OHSU’s RDW can be used to develop a patient list for recruitment (with IRB approval).
A National Cancer Institute website contains step by step strategies for recruiting participants for both cancer and non-cancer related trials.
Study Flyer and Advertisement Templates A number of study recruitment advertisement and flyer templates are available on the OHSU Branding site, including specific templates for Casey Eye Institute, Knight Cancer Institute, Doernbecher Children's Hospital, and the OHSU Brain Institute. You can customize these for your project. Remember, all study specific flyers and advertisements require approval by the OHSU Institutional Review Board (IRB) prior to use. For more information on advertising for study subjects, please see the OHSU Research Integrity Office (ORIO) policy regarding advertising for study subjects.
The OCTRI Community & Practice Research program (CPR) provides consultative assistance to investigators on the methods and logistics of community research. Their relationships with Oregon communities and practice-based research networks (PBRNs) offer additional opportunities for partnerships that can increase enrollment. They provide consultations on partnering with community organization and PBRNs.