OHSU

OHSU Biospecimen Collections

This page contains basic information about biospecimen collections at OHSU. This information is also condensed in a summary table that can be printed easily.

There are two main categories of biospecimen collections.

 

Specimen Repositories

 

Department of Pathology Archive

PI and Contact: Christopher Corless, M.D., Ph.D.

The Department of Pathology has formalin-fixed, paraffin-embedded tissue (FFPE) from over 600,000 cases dating back over a decade. This archive represents residual clinical material from a wide variety of biopsy and surgical procedures performed on OHSU patients. Diseases of nearly all types (cancers, infections, rheumatologic disorders, inflammatory conditions, etc.) are represented.

 

Knight Cancer Institute Tissue Repository

PI: Devon D. Kelly, MS, 503-494-9431
Contact: Jim Lagowski, 503-418-2079
IRB protocol #4918

This collection was started in 1999 and consists primarily of cancerous tissue collected fresh from OHSU operating rooms. Many of the specimens have matching normal tissue, as well as clinical annotative information such as patient demographics, treatments and clinical outcomes. Specimen management procedures are operationally aligned to NCI and ISBER best practices. The tissue is collected under the OHSU general consent for treatement. The genetic opt out status of the donating patients is checked prior to specimens being released for research.

As of 2012 the bank includes the following:

  • Total number of patients: 6600
  • Total number of specimens: 10,600
  • Samples of frozen tissue: 6000
  • Samples of OCT- embedded tissue: 5600
  • Samples of fomalin-fixed paraffin - embedded: 7500

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Leukemia & Lymphoma Tissue Bank

PIs: Brian Druker, M.D.; Marc Loriaux, M.D., Ph.D.
Contact: Kara Johnston
IRB protocols # 903, 1094, 4424

This bank is housed in the Druker laboratory and contains samples of peripheral blood, serum, plasma, bone marrow aspirate and lymph node tissue. Many samples are available as purified cells or extracts of DNA or RNA. The number of samples in the bank varies with different diagnoses. For example, there are many samples from patients with chronic or acute phase CML, as well as AML. There are also samples from patients with myeloproliferative disorders and myelodysplasia. Some types of lymphoma are also represented in the collection.

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Hematopathology Tissue Bank

PI: Rita Braziel, M.D.
Contact: Rita Braziel, M.D.

This bank has been in operation for more than 15 years and has samples representative of a large variety of hematologic malignancies. These include AML, myeloproliferative disorders, myelodysplasias and lymphomas. Many samples are purified populations of cells obtained from flow cytometric studies.

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Head & Neck Cancer Bank

PI: Molly Kulesz-Martin, Ph.D.
Contact: 

This bank houses fresh-frozen biopsy samples from consented patients with head & neck malignancies. Material is available from approximately 250 patients, including detailed clinical annotation.

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Prostate Cancer Bank

PI: Tom Beer, M.D.
Contact: George Thomas, M.D., Ph.D.

This bank covers several collections of normal and malignant prostate cancer tissue from clinical trials and from the NW Prostate Cancer SPORE. 

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Brain Tissue Repository (Oregon Brain Bank)

PI: Jeff Kaye, M.D.
Contact: Randall Woltjer, M.D., Ph.D.

This bank includes many hundreds of samples of frozen brain tissue from patients with many types of dementia, as well as from patients with healthy aging.

Find additional information about the Brain Tissue Repository.

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Kaiser Permanente NW Biobank

PI: Katrina Goddard, PhD
Contact: Katrina Goddard, PhD

The Biobank of Kaiser Permanente Northwest houses a growing collection of biospecimens obtained from consented patients in the Kaiser Permanente healthcare system. Administered through Kaiser’s Center for Health Research, the Biobank has access to detailed electronic medical records for patients who have given consent for their specimens to be used for research.

All research studies needing access to KPNW member’s biological samples must be vetted by the Research Biospecimen Review Committee (RBRC). This group is comprised of experienced investigators and clinicians representing KPNW, CHR, and Oregon Health & Science University. Further information is available for investigators interested in research collaborations with KPNW.

The KPNW Biobank includes these collections of biospecimens.

  • BioBank II – genomic DNA prepared from peripheral blood is available from consented breast cancer patients and normal controls/
  • Thiazide study - genomic DNA prepared from peripheral blood is available from consented patients with hypertension.
  • Kaiser NW Dept. of Pathology paraffin block archives – tissue samples from the past 30 years are available for research.

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BIOREGISTRIES

 

Personalized Cancer Medicine Registry

PI: Tomasz Beer, M.D.
Contact: Zach Stupor 6-0338
IRB protocol # 4919

The Personalized Cancer Medicine Registry (PCMR) was established in 2008 a resource for matching clinical information from consented patients with genotyping information on their cancers. As of December, 2009, 800 patients have been consented into the Registry, and tumor material has been collected from approximately 700 of these patients. The material consists primarily of archival formalin-fixed, paraffin-embedded tissue obtained either from OHSU Hospital or outside hospitals in the region. However, fresh-frozen tumor tissue from surgical procedures is available from 105 Registry patients by way of the Knight Cancer Institute Tissue Bank.

Currently, the PCMR is focused on five cancer types: colorectal adenocarcinoma, thyroid carcinoma, endometrioid carcinoma (of endometrium or ovary), bladder carcinoma, and malignant melanoma. DNA prepared from all Registry tumor samples is screened for oncogenic mutations using a mass spectroscopy-based approach (Sequenom MassARRAY system) that covers 380 known mutations across 29 genes. These include genes important in intracellular signaling, such as tyrosine kinases (EGFR, HER2, FGFR, KIT, PDGFRA), RAS genes, PI3 kinase, AKT, MAP kinases, etc. All genotyping data is stored in the PCMR database that is customized for the Registry. The database includes patient demographics, pathology findings, pathologic and clinical staging information, treatment information, and clinical follow-up information (at 6 month intervals).

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Colorectal Cancer Registry

PI: Daniel Herzig, M.D.
Contact: Miriam Douthit, 503-494-8820 or tillerym@ohsu.edu
IRB protocol # 3082

The Oregon Colorectal Cancer Registry (OCCR) was established in 2006 by the Department of Surgery at the Oregon Health & Science University in Portland, OR.  The OCCR is an extensive library of data and samples collected from individuals and families from across the country.  The purpose of the OCCR is to create a dynamic resource that will aide in the prevention and treatment of colorectal disease.

Resources:  OCCR resources are utilized for a variety of different research projects related to colorectal cancer.  Specifically, this bank contains:

  • Data on consented colon and rectal cancer patients and their family members. Data on consented subjects includes family history, gene test status, pre-op, surgical, pathological and post-op variables.
  • Blood samples on consented patients who have undergone colorectal surgery at OHSU, have a diagnosis of colon or rectal cancer or who are thought to be at risk for colon or rectal cancer or inherited syndrome.
  • Tissue (both normal and tumor) samples on consented patients who have undergone colon or rectal surgery.

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Pancreatic Cancer Registry

PI: Brett Sheppard, M.D.
Contact: Miriam Douthit, 503-494-8820 or tillerym@ohsu.edu
IRB protocol # 3609

The Oregon Pancreas Tumor Registry (OPTR) was established in 2007 by the Department of Surgery at the Oregon Health & Science University in Portland, OR.  The OPTR is an extensive library of data and samples collected from individuals and families from across the country.  The purpose of the OPTR is to create a dynamic resource that will aide in the prevention and treatment of pancreatic disease.

Resources:  OPTR resources are utilized for a variety of different research projects related to pancreatic disease.  Specifically, this bank contains:

  • Data on all pancreatic surgical cases at OHSU dating back to Jan. 1996-present.  This registry contains detailed data on patient labs, social history, medications, etc. Data on consented subjects also includes family histories and some epidemiological data.
  • Blood samples on consented patients who have undergone pancreatic surgery at OHSU, have a diagnosis of pancreatic cancer or who are thought to be at risk for pancreatic cancer. (plasma, serum, PBMC’s and pancreatic fluid)
  • Tissue (both normal and tumor) samples on consented patients who have undergone pancreatic surgery at OHSU.
  • Pancreatic ductal fluid samples on consented patients who have undergone pancreatic surgery at OHSU.

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Esophageal Cancer Registry

PI: Paul Schipper, M.D.
Contact: Miriam Douthit, 503-494-8820 or tillerym@ohsu.edu
IRB protocol # 1759

The Natural History of Esophageal Cancer and Related Diseases (ECRD) was established in 2004 by the Department of Surgery at the Oregon Health & Science University in Portland, OR.  The ECRD is an extensive library of data and samples collected from individuals and families from across the country.  The purpose of the ECRD is to create a dynamic resource that will aide in the prevention and treatment of esophageal disease.

Resources:  ECRD resources are utilized for a variety of different research projects related to esophageal disease.  Specifically, this registry contains:

  • Data on all esophagectomy surgical cases at OHSU dating back to 1994-present.
  • Specifically, data includes pre-op, surgical, pathology and post-op variables on all OHSU esophagectomy cases.
  • Data on consented subjects includes family history, quality of life scales, and follow-up data.
  • Blood samples on consented patients who have undergone esophagectomy at OHSU.
  • Tissue (both normal and tumor) samples on consented patients who have undergone esophagectomy at OHSU. (please contact the study coordinator for more information on tissue samples.)

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Liver Tumor Registry

PI: Kevin Billingsley, M.D.
Contact: Kevin Billingsley, M.D.

This registry was established to gather information on consented patients, including their family cancer history, and store samples of their liver cancer for research studies. The samples are collected primarily from surgical resections and are stored within the Knight Cancer Institute Tissue Bank.

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Ovarian Cancer Registry

PI: Tanja Pejovic, M.D., Ph.D.

Contact: Tanja Pejovic, M.D., Ph.D.

This registry was established to gather information on consented patients, including their family cancer history, and to store samples of their ovarian cancer for research studies.

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CCuRe-FAST

PI: Charles Keller, M.D.
Contact: Emma Cantor, 503-494-5895

CCuRe-FAST enrollment is open to all pediatric cancer patients at Doernbecher and OHSU. This includes all persons who have had childhood cancer, who have had a relative diagnosed with childhood cancer, or who come from a family diagnosed with familial hereditary childhood syndrome.

We are collecting all tumors or hematological malignancies, CSF, marrow, and normal tissue (such as peripheral blood mononuclear cells) from pediatric and adult patients with pediatric cancers. This registry synergizes with existing Knight resources.

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