OHSU

Child Health Research

OCTRI’s commitment to child health research extends from pilot project funding to representation on the national CTSA Child Health Oversight Committee. OCTRI provides unique support to child health and pediatric research through the Pediatric Clinical and Translational Research Center in Doernbecher Children's Hospital. The PCTRC offers a dedicated inpatient and outpatient unit in Doernbecher Children’s Hospital, RN study coordinators, and Bionutrition Unit services. Additionally, all of OCTRI's resources are available to child health & pediatric researchers.

OCTRI Child Health & Pediatric Pilot Projects

OCTRI and the Department of Pediatrics released a child health pilot project RFA in October 2008. Twenty-four letters of intent were submitted, 11 applicants were invited to submit full applications, and three projects were funded. The following list includes those three projects and additional child health projects were funded in previous pilot funding cycles.


Genetic Modifiers of Cognitive Function in Down Syndrome

Cheryl Maslen, PhD

Professor, Department of Cardiology

 

Predicting Genetic Susceptibility to Onset and Severity of Retinopathy of Prematurity (ROP) in Low Birth Weight Infants, for Pre-Pathology Diagnosis and Intervention

Mike Powers, MD

Associate Professor, Department of Pediatrics

 

Gender Differences in Pain and Somatic Complaints in Adolescence: The Role of Physical Activity

Anna Wilson, PhD

Assistant Professor, Department of Anesthesiology and Peri-Operative Medicine

 

Identifying a neurobiological correlate of ADHD using resting-state functional connectivity MRI

Damien Fair, MMSc, PhD

Postdoctoral Research Scientist, Department of Psychiatry and Behavioral Neuroscience

 

Accelerating the Pace of Translating Evidence-Based Mental Health Treatments into Practice: A Pilot Dissemination of Brief CBT for Youth Depression

Greg Clarke, PhD

Senior Investigator, Kaiser Permanente Center for Health Research

 

Metabolic Consequences of CPT1A deficiency in Alaska Native children

Melanie Gillingham, PhD, RD

Assistant Professor, Departments of Medical and Molecular Genetics

 

Tyrosine Kinases as Targets for Therapy in Pediatric Acute Lymphoblastic Leukemia

Jeff Tyner, PhD

Post Doctorate Fellow, OHSU Department of Medicine, Division of Hematology and Medical Oncology


OCTRI Support for Child Health & Pediatric Research Projects

The following list is a selection of child health and pediatric projects supported by OCTRI resources.

 

National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Related Cardiovascular Conditions - Northwest Center

Cheryl Maslen, PhD

Professor, Department of Molecular and Medical Genetics

OCTRI Resources:

  • Investigator Support and Integration Services
  • Front Door
  • CTRC Outpatient Nursing
  • Study coordinators
  • Translational Technologies / Core Laboratory

In-Utero Smoke, Vitamin C and Newborn Lung Function

Cynthia McEvoy, MD

Associate Professor, OHSU Department of Pediatrics, Division of Neonatology

OCTRI Resources:

  • Clinical and Translational Research Center
  • Study coordinators

Laparoscopic vs. Open Appendectomy in Children: A Prospective, Randomized Controlled Trial

David Bliss, MD

Assistant Professor, Department of Surgery

OCTRI Resources:

  • Front Door assistance to negotiate project recruitment at Kaiser Permanente Northwest
  • Informatics

Seasonal rhythms of salivary melatonin, sleep and activity in children with attention deficit hyperactivity disorder (ADHD): a pilot study

George Keepers, MD

Chair, OHSU Department of Psychiatry

OCTRI Resources:

  • CTRC Outpatient Nursing
  • Translational Technologies / Core Laboratory

Genetic Analysis of PHACES syndrome

Dawn Siegel, MD

Assistant Professor, OHSU Department of Dermatology

OCTRI Resources:

  • Front Door
  • Clinical and Translational Research Center
  • Translational Technologies / Core Laboratory
  • Biostatistics
  • Investigator Support and Integration Services

Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR)(*jp*)

Steven Skoog, MD, FAAP

Professor, OHSU Department of Surgery, Division of Urology

OCTRI Resources:

  • Translational Technologies / Core Laboratory

Effects of in utero methamphetamine exposure on object recognition and spatial navigation among 58 healthy children

Jacob Raber, PhD

Associate Professor, OHSU Departments of Neurology and Behavioral Neuroscience

OCTRI Resources:

  • Data analysis

Melatonin Studies in Young Blind Children and Adolescents

Alfred Lewy, MD, PhD

Professor, OHSU Department of Psychiatry

OCTRI Resources:

  • Translational Technologies / Core Laboratory

Fatty Acid Oxidation Disorders & Body Weight Regulation

Melanie B. Gillingham, PhD, RD

Assistant Professor, OHSU Department of Molecular and Medical Genetics, OHSU Dietetics and Nutrition Program

OCTRI Resources:

  • Bionutrition Unit
  • Investigator Support and Integration Services

Fever and Neutropenia in Pediatric Oncology Patients: A randomized, controlled, multicenter study of outpatient therapy and evaluation of genomic and proteomic correlates

Linda Stork, MD

Professor, OHSU Department of Pediatrics, Division of Hematology/Oncology

OCTRI Resources:

  • Translational Technologies / Core Laboratory
  • Clinical and Translational Research Center

A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Study Evaluating the Efficacy and Safety of ALTU-135 Treatment in Patients with Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency

Michael Wall, MD

Professor, Department of Pediatrics

OCTRI Resources:

  • CTRC Inpatient Nursing
  • Bionutrition Unit

Study of Adolescent Depression

Gregory Clarke, PhD

Senior Investigator, Kaiser Permanente Center for Health Research

OCTRI Resources:

  • Community program assistance with accessing health networks