Lisa C. Silbert, M.D., M.C.R.

Lisa C. Silbert, M.D., M.C.R.

Associate Professor of Neurology


Lisa C. Silbert is an Associate Professor in the Division of Neurology at Oregon Health & Science University School of Medicine and Director of the Neuroimaging Lab at the Oregon Aging and Alzheimer's Disease Center. She completed her neurology residency at UCLA and fellowship training in both Geriatric Neurology and Clinical Neurophysiology at OHSU.

Dr. Silbert's clinical practice consists primarily of patients with neurodegenerative disease affecting cognitive function. In addition, she provides intraoperative neurophysiological monitoring and electroencephalogram interpretation. 

Dr. Silbert's research focuses on the effects of cerebral white matter change on cognitive and motor function in the elderly. She is interested in how differing rates of white matter change may affect cognitive and motor function, and is currently using high field MRI and DTI to follow micro and macrostructural changes in the white matter over time in the elderly. She has received funding for this work from the Alzheimer's Association, the American Academy of Neurology Foundation, and the NIH/NIA, including an Alzheimer's Disease Center grant and a K23/Paul B. Beeson career development award in aging research. She has been awarded an NIH/NIA R01 award investigating the effects of longitudinal changes in cerebral blood flow, as measured by arterial spin labeling (ASL), on white matter change and cognitive and motor function in the elderly.



IU School of Medicine: MD

UCLA: Neurology Residency

OHSU: Clinical Neurophysiology Fellowship

OHSU: Aging and Alzheimer's disease Fellowship

OHSU: Masters in Clinical Research


Silbert LC., Durocher A., and Biller J.  The “S” in MELAS.  Journal of Stroke and Cerebrovascular Diseases; volume 6, number 2: 67-71, 1996.

Montine TJ., Quinn JF., Milatovic D., Silbert LC., Dang T., Sanchez S., Terry E., Roberts LJ 2nd., Kaye JA., Morrow JD. Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Annals of Neurology. 52(2):175-9, 2002 Aug.

DB Howieson, PhD, R Camicioli, MD, J Quinn, MD, LC Silbert, MD, B Care, MM Moore, A Dame, G Sexton, PhD, JA Kaye, MD. Natural History of Cognitive Decline in the Old Old. Neurology. 60:1489-1494, 2003May.

Silbert LC., Quinn JF., Moore MM., Corbridge E., Ball MJ., Murdoch, G., Sexton, G., Kaye, JA. Changes in Premorbid Brain Volume Predict Alzheimer’s  disease Pathology. Neurology. 61(4):487-492,2003 August.

Deniz Erten-Lyons, Diane B. Howieson, M. Milar Moore, Joseph Quinn, Gary Sexton, Lisa C. Silbert, and Jeffrey A. Kaye. Brain volume loss in MCI predicts dementia. Neurology. 66(2): 233-235, 2006

LC Silbert, K Nelson, BA Holman, R Eaton, MS Oken, JS Lou, and JA Kaye. Cortical excitability and age-related volumetric MRI changes. Clinical Neurophysiology. 117(5):1029-36, 2006 May.

J.A. Kaye, MD;  M.M. Moore, B.S.; D. Galasko, MD; U.K. Craig, PhD; R. Adonay, B.S.; and L. Silbert, MD. Brain Volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults. Neurology. 69(2):196-9, 2007 July

Douglas Galasko, David P. Salmon, Anthony Gamst, John Olichney, Leon J. Thal, Lisa C. Silbert, Jeffrey A Kaye, Peter Brooks, Roy Adonay, Ulla-Katrina Craig, Gerard Schellenberg, and Amy R Borenstein. Prevalence of dementia in Chamorros on Guam: relationship to age, sex, education and APOE. Neurology. 68: 1772-1781, 2007.

Amy R. Borenstein, James A. Mortimer, Elizabeth Dahlquist, Yougui Wu, David P. Salmon, Anthony Gamst, John Olichney, Leon J. Thal, Lisa Silbert, Jeffrey A Kaye, Ulla-Katrina Craig, Gerard Schellenberg, and Douglas Galasko. Cycad seed exposure and risk of Guam Dementia, MCI and ALS/PDC in the Chamorro population of Guam. Neurology. 68: 1772-1781, 2007.

Lisa C Silbert. Does statin use decrease the amount of Alzheimer disease pathology in the brain? Neurology; 69: E8-E11, 2007

Nichole E Carlson, Mindy Milar Moore, Alison Dame, Diane Howieson, Lisa C. Silbert, Joseph Quinn, and Jeffrey Kaye. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology.  Neurology;70:828-833, 2008.

LC Silbert, C Nelson, DB Howieson, MM Moore, JA Kaye. Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline. Neurology. 71(2):108-113, 2008.

LC Silbert, DB Howieson, H Dodge, JA Kaye. Cognitive Impairment Risk: White Matter Hyperintensity Progression Matters. Neurology; 73: 113-119, 2009.

LC Silbert, JA Kaye. Neuroimaging and Cognition in Parkinson's Disease Dementia. Brain Pathology. 20(3):646-653, 2010. PMCID:PMC3327506

Woltjer RL, Duerson K, Fullmer, J, Mookherjee P, Ryan AM, Montine TJ, Kaye JA, Quin, JF, Silbert L, Erten-Lyons D, Leverenze JB, Bird TD, Pow EV, Watson S, and Cook DG. Aberrant Detergent-insoluble EAAT2 Accumulates in Alzheimer Disease. Journal of Neuropathology and Experimental Neurology; 69(7):667-76, 2010.

Deniz Erten-Lyons, Beth Wilmot, Pavana Anur, Shannon Mcweeney, Shawn Westaway, Lisa Silbert, Patricia Kramer, Jeffrey Kaye, and for the Alzheimer’s Disease Neuroimaging Initiative. Microcephaly genes and risk of late onset Alzheimer Disease. Alzheimer Disease & Associated Disorders;25(3):276-82, 2011.

Gene L Bowman, Lisa C. Silbert, Hiroko Dodge, Jackilen Shannon, Diane Howieson, Jeffrey Kaye, Joseph Quinn. Nutrient Biomarker Patterns, Cognitive Function, and MRI Measures of Brain Aging: A Proof of Principle Study. Neurology;78:241-249, 2012.

Silbert LC, Dodge HH, Perkins LG, Sherbakov L, Lahna D, Woltjer R, Shinto L, Kaye JA. Trajectory of White Matter Hyperintensity Burden Preceding Mild Cognitive Impairment. Neurology. 79:741-747, 2012. PMC3421153

D Erten-Lyons, R. Woltjer, HH Dodge, DB Howieson, LC Silbert, P Kramer, JA Kaye. Neuropathological basis of age-associated brain atrophy. JAMA Neurology;70(5):616-22, 2013. PMID:23552688

Deniz Erten-Lyons, Randall Woltjer, Jeffrey A. Kaye, Nora Mattek, Hiroko H. Dodge, Sarah C. Green, Huong Tran, Diane B. Howieson, Katherine Wild, Lisa C. Silbert. Neuropathologic Basis of White Matter Hyperintensity Accumulation with Advanced Age. Neurology;81(11):977-83, 2013. PMID in process.

Lynne Shinto, Joseph Quinn, Thomas Montine, Hiroko H Dodge, William Woodward, Sara Baldauf-Wagner, Dana Waichunas, Laren Bumgarner, Dennis Bourdette, Lisa Silbert, Jeffrey Kaye. A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer’s Disease. Journal of Alzheimer’s and Dementia. In Press 2013.


Phone: 503 494-6976

Fax: 503 494-7499