Hiroko H. Dodge, Ph.D.

Hiroko H. Dodge, Ph.D.



Data Core Director/Associate Professor of Neurology



Dr. Dodge has been directing two Alzheimer's Disease (AD) Centers' Data Cores jointly: the NIA-funded Layton Aging and Alzheimer's Disease Center (ADC) at Oregon Health &Science University (OHSU) and the Michigan ADC. She has over 20 years of experience working as a statistician in the field of dementia research. In addition to her statistical expertise, her research interests cover a wide range of areas, including epidemiology of dementia, cross cultural comparisons on healthy aging between Okinawa, Japan and Oregon collaborating with the Okinawa Centenarian Study project, application of demographic methods to clinical research, longitudinal data analyses and clinical trial methods. She recently created a Professional Interest Area (PIA) entitled "Clinical Trials Advancements and Outcomes" in the International Society to Advance Alzheimer's Research (ISTAART, an international AD research organization sponsored by the Alzheimer's Association). This PIA creates an international researchers' forum where innovative clinical trial approaches, developments of outcomes sensitive to trial effects, and unique non-pharmacological trials are being introduced and discussed. (For more information: https://act.alz.org/site/SPageServer?pagename=ISTAART_PIA_CTAM ).  Her most recently completed NIA funded R01 examined whether stimulations through social interactions using modern communication technologies (pc, webcams and Internet) could improve cognitive functions. She holds Fellow status at the Gerontological Society of America and serves as a statistical editor for several dementia related journals.


Pennsylvania State University. PhD. 1992



Phone: 503 494 6977

Email: dodgeh@ohsu.edu


Representative Publications

  1. Dodge HH, Shen C, Pandav R, DeKosky ST, Ganguli M.  Functional Transitions and Active Life Expectancy Associated with Alzheimer’s Disease. Archives of Neurology, 2003;60:253-259.
  2. Dodge HH, Du Y, Saxton JA, Ganguli M. Cognitive domains and trajectories of functional independence in non-demented elderly.  The Journal of Gerontology: Medical Sciences, 2006;61(12):1330-1337 http://www.ncbi.nlm.nih.gov/pubmed/17234830
  3. Dodge HH, Zitzelberger T, Oken BS, Howieson D, Kaye JA. A Randomized Placebo-Controlled Trial of Ginkgo Biloba for the Prevention of Cognitive Decline. Neurology, 2008; 70:1809-1817.  (PMC2639649)
  4. Dodge HH, Kita Y, Takechi H, Hayakawa T, Ganguli M, Ueshima H. Healthy Cognitive Aging and Leisure Activities among the Oldest Old in Japan: Takashima Study, Journal of Gerontology: Medical Sciences (special issue on healthy aging), 2008; 63:1193-1200. (PMC2646000). http://www.ncbi.nlm.nih.gov/pubmed/19038834
  5. Dodge HH, Meguro K, Ishii H, Yamaguchi S, Saxton JA, Ganguli M. Cross-cultural comparisons of the mini-mental state examination between Japanese and US cohorts. International Psychogeriatrics 2009; 21(1):113-22 (PMC2639652) http://www.ncbi.nlm.nih.gov/pubmed/18925977
  6. Dodge HH, Chang CC, Kamboh MI, Ganguli M. Risk of Alzheimer's disease incidence attributable to vascular disease in the population. Alzheimer's & Dementia 2011;7:356-360. (PMC3291093).
  7. Dodge HH, Wang CN, Chang CC, Ganguli M. Terminal decline and practice effects in non-demented older adults: the MoVIES project. Neurology, 2011:77;722-730. (PMC3164394) http://www.ncbi.nlm.nih.gov/pubmed/21832224
  8. Dodge HH, Mattek NC, Austin D, Hayes TL. In-home walking speeds and variability trajectories associated with Mild Cognitive Impairment. Neurology, 2012: 78(24):1946-1952. (PMC3369505)
  9. Dodge HH, Buracchio TC, Fisher G, Kiyohara Y, Meguro K, Tanizaki Y, Kaye JA. Trends in the prevalence of dementia in Japan.  International Journal of Alzheimer’s Disease, 2012, 956354 (PMC3469105). http://www.ncbi.nlm.nih.gov/pubmed/23091769
  10.   Dodge HH, Ybarra O, Kaye JA. Tools for advancing research into social networks and cognitive functions in older adults. International Psychogeriatrics. 2014 April; 26(4): 533–539. (PMC3943694) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943694/11.    
  11. Dodge HH, Zhu J, Lee C-W, Chang C-CH, Ganguli M. Cohort Effects in Age-Associated Cognitive Trajectories. J Gerontol A Biol Sci Med Sci. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):687-94. (PMC4022091) http://www.ncbi.nlm.nih.gov/pubmed/2427006212.    
  12. Dodge HH, Zhu J, Mattek N, Austin D, Kornfeld J, Kaye J. Use of high-frequency in-home monitoring data may reduce sample sizes needed in clinical trials. Plos One 2015:17;10(9):e0138095. doi: 10.1371/journal.pone.0138095 (PMC4574479) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.013809513.    
  13. Dodge HH, Zhu J, Mattek N, Bowman BA, Gregor BA, et al. Characteristics associated with willingness to participate in a randomized controlled behavioral clinical trial using home-based personal computers and a webcam. Trials, 2014;15:508. (PMC4307639). http://www.ncbi.nlm.nih.gov/pubmed/2553963714.    
  14. Dodge HH, Mattek N, Gregor M, Bowman M, Seelye A, Ybarra O, Asgari M, Kaye JA. Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech. Current Alzheimer Research, 2015;12(6):513-9. http://www.ncbi.nlm.nih.gov/pubmed/2602781415.    
  15. Dodge HH, Zhu J, Mattek N, Bowman M, Ybarra O, Wild K, et al. Web-enabled conversational interactions as a method to improve cognitive functions: Results of a 6-week randomized controlled trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2015: 1:1-12. (PMC4507295) http://www.ncbi.nlm.nih.gov/pubmed/26203461