Neuropathology Core

Severe AD

92 Year Old Male, Severe AD

Cognitively Healthy

92 Year Old Male, Cognitively Healthy

The Neuropathology Core of the Layton Center for Aging and Alzheimer’s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer’s Disease Center Clinical Core. The focus of the core is threefold:

  • From a diagnostic viewpoint, for those subjects who are enrolled in our research studies, we provide their physicians and families with diagnostic information and autopsy reports that are based on the most current standardized criteria.
  • From a research perspective, we support scientific efforts by collecting, storing and distributing samples of well-prepared brain tissue. We also provide neuropathologic data from longitudinally characterized patients with mild cognitive impairment/dementia as well as non-cognitively impaired control individuals.
  • From a teaching perspective, we train and mentor individuals in the current methods of neuropathological classification of neurodegenerative diseases and age-related changes. These students come from the basic sciences as well as pathology, neurology, psychology, and psychiatry.

In 2003, the Neuropathology Core of the Alzheimer’s Disease Centers at Oregon Health & Science University partnered with the Neuropathology Core at the University of Washington to create PANDA - The Pacific Northwest Dementia and Aging Neuropathology Group. This unique partnership between OHSU and UW enables these two premier universities of the Northwest to standardize their methodology and helps to better serve the diverse population of the Pacific Northwest.

An important component of PANDA is the Oregon Brain Bank (OBB) which was established in 1990 with the assistance of the Alzheimer Research Alliance of Oregon and the National Institute on Aging-funded Alzheimer’s Disease Center at OHSU. Through this program, brain autopsies are performed for diagnostic and research purposes. The Oregon Brain Bank is directed by Dr. Randy Woltjer. Learn more about brain tissue research.

For further information about the Neuropathology Core, please contact Dr. Randy Woltjer at woltjerr@ohsu.edu or 503 494-8276.