Agency for Healthcare Research and Quality (AHRQ)

AHRQ is the health services research arm of the U.S. Department of Health and Human Services (HHS), complementing the biomedical research mission of its sister agency, the National Institutes of Health. AHRQ funds research on health care quality, costs, outcomes, and patient safety.As a part of their functions AHRQ funds Evidence Based Practice Centers in the US and Canada, which specialize in the conduct and methods of systematic reviews.

Canadian Agency for Drugs & Technologies in Health (CADTH)

The mission of CADTH (formerly known as the Canadian Coordinating Office for Health Technology Assessment or CCOHTA) is to provide timely, relevant, rigorously derived, evidence-based information about drugs and other health technologies as well as support the decision-making process in Canada. Federal, provincial and territorial health care decision makers rely on CADTH to provide them with credible information and impartial advice, unlike regulators who determine which drugs or technologies should be used to achieve the best outcomes both on patient health and the health care system.

The Cochrane Collaboration

The Cochrane Collaboration is an international collaboration of researchers for the purpose of conducting and disseminating the results of systematic reviews. This group also conducts research in the methodology of systematic reviewing.

Effective Health Care

Effective Health Care is a section of the Medicare Modernization Act of 2003 (MMA) that focuses on effectiveness and improved health outcomes. This section of MMA authorizes the Agency for Healthcare Research and Quality (AHRQ) to conduct research, demonstrations, and evaluations designed to improve the quality, effectiveness, and efficiency of Medicare, Medicaid and the State Children’s Health Insurance Program (SCHIP). The program emphasizes a transparent process with public input. Its goals are: (1) to develop valid evidence about the comparative effectiveness of different treatments and appropriate clinical approaches to difficult health problems and (2) to make the information easily accessible and understandable to decision makers.

National Coordinating Center for Health Technology Assessment (NCCHTA)

NCCHTA is an organization funded by the UK Department of Health to provide health technology assessment to the National Health Service. As a part of this research, broad scale systematic reviews are commissioned to be undertaken covering a wide range of health care topics, including systematic review methods.

National Institute for Clinical Excellence (NICE)

NICE is part of the National Health Service (NHS) in the UK, and its role is to provide patients, health professionals and the public with authoritative, robust and reliable guidance on current "best practice". As a part of their remit, NICE commissions technology assessments which include both systematic reviews of clinical evidence and economic evaluations of interventions, such as drugs.

NHS Centre for Reviews and Dissemination (CRD)

The Centre for Reviews and Dissemination (CRD) at the University of York, UK, aims to provide research-based information about the effects of interventions used in health and social care. It helps to promote the use of research-based knowledge, by conducting systematic reviews of research on selected topics and maintaining three databases: DARE, NHS EED and the (UK) HTA database. CRD undertakes reviews for a variety of organizations, including the UK department of Health, NICE, and others.