OHSU

Pierre Moënne-Loccoz

Pierre Moenne Loccoz

Associate Professor
Institute of Environmental Health; Division of Environmental and Biomolecular Systems
Office: Hatfield Research Center, 3rd floor, Room 354
Phone: 503-346-3429
Email: 


Education

Diplome d'Etudes Approfondies de Biophysique Moleculaire de l'Universite Pierre et Marie Curie Paris VI, 1987
Doctorat de l'Universite Pierre et Marie Curie, Paris VI, 1989

 

Biography

  • University of Oregon, Postdoctoral Research Associate, Department of Chemistry, 1990-92
  • University College London, Department of Biology, 1992-93
  • OHSU/OGI School of Science & Engineering, 1994-95; Research Scientist, 1996-1999; Research Assistant Professor, 1999-2000; Assistant Professor, 2000-2007

 

Research Interests

Structure-function relationships within proteins. Metalloenzymes and hemoproteins. Spectroscopic studies of enzymatic active sites, cofactors, and metal clusters. Reaction intermediates within catalysis. Nitric oxide in bioinorganic chemistry.

 

Selected Publications

Ritesh Kumar; Scott Lovell; Hirotoshi Matsumura; Kevin P. Battaile; Pierre Moënne-Loccoz; Mario Rivera
The hemophore HasA from Yersinia pestis (HasAyp) coordinates hemin with a single residue, Tyr75, and with minimal conformational change
Biochemistry. 2013;52(16):2705-2707.

Sumit Sahu; Leland R. Widger; Matthew G. Quesne; Sam P. De Visser; Hirotoshi Matsumura; Pierre Moënne-Loccoz; Maxime A. Siegler; David P. Goldberg
Secondary coordination sphere influence on the reactivity of nonheme iron(II) complexes: An experimental and DFT approach
Journal of the American Chemical Society. 2013;135(29):10590-10593.

Santhosh Sivaramakrishnan; Hugues Ouellet; Hirotoshi Matsumura; Shenheng Guan; Pierre Moënne-Loccoz; Alma L. Burlingame; Paul R. Ortiz De Montellano
Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion
Journal of the American Chemical Society. 2012;134(15):6673-6684.

Takahiro Hayashi; Jonathan D. Caranto; Hirotoshi Matsumura; Donald M. Kurtz; Pierre Moënne-Loccoz
Vibrational analysis of mononitrosyl complexes in hemerythrin and flavodiiron proteins: Relevance to detoxifying no reductase
Journal of the American Chemical Society. 2012;134(15):6878-6884.

Nhut Giuc Tran; Harris Kalyvas; Kelsey M. Skodje; Takahiro Hayashi; Pierre Moënne-Loccoz; Paige E. Callan; Jason Shearer; Louis J. Kirschenbaum; Eunsuk Kim
Phenol nitration induced by an {Fe(NO)2}10 dinitrosyl iron complex
Journal of the American Chemical Society. 2011;133(5):1184-1187.

Erik T. Yukl; Alexandra Ioanoviciu; Santhosh Sivaramakrishnan; Michiko M. Nakano; Paul R. Ortiz De Montellano; Pierre Moënne-Loccoz
Nitric oxide dioxygenation reaction in devS and the initial response to nitric oxide in mycobacterium tuberculosis
Biochemistry. 2011;50(6):1023-1028.

Paul J. Focke; Pierre Moenne-Loccoz; H.Peter Larsson
Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate
Journal of Neuroscience. 2011;31(16):6255-6262.

Takahiro Hayashi; Kyle D. Miner; Natasha Yeung; Ying-Wu Lin; Yi Lu; Pierre Moënne-Loccoz
Spectroscopic characterization of mononitrosyl complexes in heme-nonheme diiron centers within the myoglobin scaffold (FeBMbs): Relevance to denitrifying No reductase
Biochemistry. 2011;50(26):5939-5947.

Frances Namuswe; Takahiro Hayashi; Yunbo Jiang; Gary D. Kasper; Amy A. Narducci Sarjeant; Pierre Moënne-Loccoz; David P. Goldberg
Influence of the nitrogen donors on nonheme iron models of superoxide reductase: High-spin FeIII-OOR complexes
Journal of the American Chemical Society. 2010;132(1):157-167.

Loi H. Do; Takahiro Hayashi; Pierre Moënne-Loccoz; Stephen J. Lippard
Carboxylate as the protonation site in (peroxo)diiron(III) model complexes of soluble methane monooxygenase and related diiron proteins
Journal of the American Chemical Society. 2010;132(4):1273-1275.

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