OHSU Institute of Environment Health is well equipped for research ranging from laboratory work in biochemistry, molecular biology, and microbiology; to modeling and simulation of processes at the molecular and regional scales; to field study of estuarine and groundwater environments. On this web page, we do not display all of our equipment, but rather provide brief descriptions of resources that are shared by the whole Institute, unique facilities that developed as a result of long-standing strengths of the Institute in specific areas of research, and significant instrumentation that has been acquired recently.
Hatfield Research Center
Most of the Institute's laboratories and offices are located on the 3rd floor of the Hatfield Research Center. The main entrance of Hatfield Research Center on S.W. Sam Jackson Park Road. Take the G elevator down to the 3rd floor. Additional labs and offices are located in the Richards Jones Hall and the Biomedical Information Communication Center. Get directions to the Hatfield Research Center
Science and Technology University Research Network (SATURN)
SATURN is a river-to-shelf collaboratory that is an integration of networked sensors, platforms, models, data, analyses, and social processes. SATURN is composed of an Observation Network that collects physical and biogeochemical data from fixed stations and mobile devices and the Virtual Columbia River, a skill-assessed 4D simulation environment that offers multiple representations of circulation processes, variability and change across river-to-shelf scales. The SATURN modeling system and observation network are integrated via an end-to-end computational infrastructure.
IEH is equipped for spectroscopic characterization of biological free radicals and metalloprotein complexes using a combination of approaches, including electron paramagnetic resonance, vibrational, and magnetic circular dichroism spectroscopies. Instrumentation available for EPR spectroscopy includes a Bruker E-500 X-Band EPR spectrometer. Instrumentation available for vibrational spectroscopy includes a Perkin-Elmer System 2000 FTIR spectrometer. Instrumentation available for MCD spectroscopy includes a custom spectrometer based on an Aviv Associates Model 41 DS scanning CD monochromator.
Laser confocal microscopy allows the microscopist to obtain fluorescence images from a discrete plane of focus, even in complex samples. The data from these optical sections can be combined to provide detailed three dimensional information about a sample. Confocal microscopy is particularly useful for investigating the identities and activities of microbes in their natural context. Our new confocal microscopy facility consists of a Zeiss LSM 5 Pascal three laser system with both upright and inverted microscope stands. Also included is a unique Zeiss technology, the ApoTome, which allows optical sectioning at any wavelength using "grid projection" or "structured illumination". A CCD camera captures images in three defined steps, as a grid of stripes of defined width is projected onto the focal plane of the objective and shifted laterally. On-line computation is used to combine the three "raw" images into an optical section through the sample, which is free of artifacts, with out-of-focus information removed. This device allows the user to approximate results achieved with laser scanning microscopy, in a fraction of the time.