OHSU

Tshala-Katumbay Lab

Our research activities focus on:

Elucidating mechanisms of neurodegenerative diseases associated with exposure to xenobiotics, nutritional deficiencies, and genetic polymorphisms.  Our “environmental model” of choice is konzo (see movie below), a distinct upper motor neuron disease associated with food cyanogens found in cassava aka tapioca, low dietary intake in sulfur amino acids cystein and/or methionine, and yet to be explored genetic polymorphisms in rhodanese (thiosulfate sulfurtransferase). Our “occupational model” explores mechanisms by which industrial solvents, e.g. n-hexane and diethylbenzene derivatives induce axonal diseases. In these models, we used active metabolites of toxicants of interest to track molecular and cellular events associated with incipient and extant neurological diseases.

We are also engaged in the development of novel tools that can be used to selectively enter motor neurons and capture the dynamic of protein posttranslational modifications (PTM) associated with neurodegenerative mechanisms.  PTM are studied using state-of-the-art proteomic methodologies including MALDI-TOF/MS-MS and LC/MS-MS. In addition to the diagnostic relevance, such tools may also be used to deliver to the nervous system molecules with putative neuroprotective properties.


Movies:


Popokabaka_Congo                                          Kahemba, Congo 2009
Konzo in Popokabaka, Congo, 1996                          Konzo in Kahemba, Congo, 2009


Kasai1                                          Kasai2
Unexplored form of disability, Kasai, Congo, 2009    Unexplored form of disability, Kasai, Congo, 2009

Working Group

National

Desire-TshalaAna-Luiza-Ramos-CrawfordRoman-KassaMorris-KimHanna-Harper_2

International

Faculty Collaborators

Dieudonné Mumba NgoyiMutambo Lukasa, MD, PhDDr. Luwa-Okitundunew

Postdoctoral Student

Nadege-Ngombe

Students

Jean-Marie-KashamaSamuel-KimaniBumoko-Makila-MabeRobert-MussaGraham-KimSadiki Ngeleza