OHSU

Lloyd-McCullough Group Members

Dr. Irina Minko, Staff Scientist

Irina-4

Irina attended the Moscow State University and the Institute of Biochemistry of Russian Academy of Sciences. In 1999, she joined the Lloyd lab at the University of Texas Medical Branch in Galveston, Texas and continued her research when the lab transitioned to OHSU, Portland.  Irina's work has been developed in the following directions: (i) The biochemical and cellular processing of DNA-protein cross-links; (ii) The role of specialized DNA polymerases in the bypass of DNA lesions;  and (iii) The mutagenic consequences of cellular processing of damaged DNA. Currently, the main focus of Irina's research is on repair of DNA-DNA cross-links.

email me  - publication history


Dr. Anuradha Kumari, Senior Research Associate

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Dr. Kumari received her PhD degree in 2004 from the Institute for Cancer Studies at University of Sheffield in the United Kingdom under the guidance of Dr. Thomas Helleday. Her PhD work focused on 1) studying thymidine-induced recombination intermediate generated at stalled replication forks, and 2) understanding the protective roles of p53 and TLS polymerases (eta and iota) at stalled replication forks. In 2005, she came to the US as a postdoctoral trainee in the lab of Dr. Hua Lu in the Dept. of Biochemistry and Molecular Biology (OHSU), where she worked on identifying the role of a chromatin associated protein, SSRP1, in homologous recombination-mediated repair in conjunction with another recombination-associated protein, Rad54. In 2007, she joined the Lloyd and McCullough lab where she has been involved in multiple projects relevant to cellular DNA damage responses invoked by DNA-DNA and DNA-protein crosslinking agents. Two of the ongoing projects utilize E. coli models to study the contribution of DNA repair helicases and polymerases in response to DNA damaging agents, such as formaldehyde, Mitomycin C, and ultra-violet rays. The other two projects involve cell culture systems and are focused on understanding the repair mechanisms associated with formaldehyde-induced DNA damage. In her spare time, she enjoys nature photography, and working with beads and stones (i.e., jewelry making in case you have not guessed it!).

email me - publication history


Dr. Harini Sampath, Postdoc

Harini Sampath

Harini Sampath completed her doctoral training in Biochemical and Molecular Nutrition at the University of Wisconsin-Madison in 2008.  Having obtained extensive training in lipid and carbohydrate metabolism and ER stress pathways in the development of obesity, Dr. Sampath joined the Lloyd lab in 2009.  She is currently interested in delineating the molecular pathways leading to metabolic dysfunction in mice deficient in the DNA glycosylase, NEIL1.  Her studies are particularly focused on understanding the relationships between oxidative stress, mitochondrial dysfunction, and metabolic syndrome.  In her free time, Harini enjoys traveling and developing recipes for her vegetarian food blog.

email me - CV - publication history


Dr. Marcus Calkins, Postdoc

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Marcus grew up in Oregon, but moved to Wisconsin where he received a degree in Molecular and Environmental Toxicology from University of Wisconsin-Madison in 2008.  His early studies focused on mechanisms of protection from oxidative insults, culminating in a thesis which involved stimulation of Antioxidant Response Element mediated transcription to provide prophylactic protection from neurotoxins.  After receiving his degree, he returned to Oregon to study mitochondrial involvement in the progression of Alzheimer's disease.  He then changed focus to join the Lloyd-McCullough lab in 2011 to work on UV damage response.  (He is especially interested in methods to increase repair of UV damaged DNA.)  In his free time, Marcus enjoys the high quality of life that living in Portland affords, with a special love for being able to drink the tap water. 

email me - publication history


Dr. Richard Kleinschmidt, Senior Research Assistant

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Richard received his PhD in molecular biology/genetics from Louisiana State University in 2011 under the guidance of Dr. David Donze.  His graduate work mainly focused on gene regulation through chromatin boundary elements in S. cerevisiae.  Prior to graduate school, he  worked as a research technician at Emory School of Medicine in Atlanta, GA and Children's Hospital for Research Institute in New Orleans, LA.  He moved to Oregon last year and is now working with yeast in the Lloyd/McCullough lab to determine the gene pathways responsible for formaldehyde-induced DPCs (DNA-protein crosslinks) and subsequent mechanisms of DNA repair.  Richard enjoys living in Portland and everything the Pacific Northwest has to offer.

email me - publication history


Stacey Lin, Graduate Student

Stacey

Stacey grew up in Taiwan, where she received her Bachelor's degree in Forestry from National Taiwan University.  After receiving her degree, she worked as a technician at the University of Pittsburgh where she grew to enjoy molecular biology in the lab of Dr. Tawbi. She came to Portland in 2010 for the PMCB program at OHSU, where she joined the Lloyd-McCullough lab. Her current work focuses on repair glycosylases and polymerases.  She is interested in the mutagenic spectrum of aflatoxin and the ability of cells to bypass and repair the lesion.  When not in lab, Stacey enjoys hiking, music and trying new foods from a variety of cuisines.

email me - publication history


Eleonora Juarez, Gruaduate Student

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Ellie is from Monterrey, Mexico and grew up in Brownsville Texas. She received her Bachelors of Science in Biology from The University of Texas at Brownsville. She came to Portland in the fall of 2011 and joined the PMCB program at OHSU. She is currently a graduate student in the Molecular and Medical Genetics Department and a member of the McCullough-Lloyd lab. Her current work focuses on the importance of chromatin remodeling for the processing of DNA-protein crosslinks induced by formaldehyde exposure. When not in lab she loves exploring new cuisines and restaurants in around the Pacific Northwest, and attending all sorts of sports events. GO SPURS GO!

email me - CV - publication history


Dr. Vladimir Vartanian, Research Technician

Vladimir Vartanian

Vladimir received a PhD degree in Linguistics from the Institute of Linguistics at the Russian Academy of Sciences in Moscow. His interests focused on the psychological and social aspects of language. He became interested in biological research and joined the lab in 2003. He currently studies the role of oxidative stress and was first to observe the metabolic syndrome in NEIL1 deficient mice. In his free time, Vladimir enjoys creating art with an emphasis on drawing and painting.  Selections of his work are available for purchase through Forever Art.

email me - publication history


Visiting/Rotating Members

Amber Bannon- OHSU Program in Molecular and Cellular Biosciences (Rotation)

Former Lab Members

Lloyd-McCullough Lab


Faculty Members:

M.L. "Buddy" Dodson -

Valeri Kossykh -


Postdoctoral Fellows: 

Adam Clore - Scientist, Integrated DNA Technologies

Paul House -

Aaron Jacobs -

Jodi Johnson - Postdoc, Northwestern U.

Ana Sanchez - Professor, Department of Chemistry at Galveston College

Afsaneh Tavana - Professor, Tehran U., Iran

Tatyana Ustinnikova - Senior Res. Scientist, Russian Acad. Sciences

Randy Walker - Scientist, Perkin Elmer


Graduate Students:

Bendert de Graaf - Project Manager, Vitens

Priscilla Fernandes - Assistant Laboratory Director, Myriad Genetics

Andy Kurtz - Science Policy Fellow, NIH

Yun Xin Lim - Covance Inc

Khoa Nguyen - Postdoc, Harvard Medical School

Brie Schaeffer -

Kinrin Yamanaka - Postdoc, MIT


Research Assistants/Associates:

Heather Bassett - 

Lauriel Earley - Graduate Student, OHSU (Grompe Lab Rotation)

Mike Harbut - Graduate Student, U. Penn

Ritche Jabil - 

Alex Klug - 

Brian Lowell - Medical Student, OHSU

Michael Meador - 

Daun Milligan - 

Laura Roy - 

Olga Ryabinina - Research Associate, OHSU (Iordanov Lab)

Steve Wooden - 

Hongbing Zhu - 

 

Undergraduate Students:

Ashley Bynum - 

Cristian Dan - 

Tammy Luoh - 

Megan Macfarlane - 

Kaki Marshall - 

Chelsea Mayo - 

Rebecca Smith - 

John Stewart - 

Jeff Zhou - 

 

International Visiting Students:

Erik Bom - Student, MSc Drug Discovery and Safety

Vincent de Maat - 

Esmee Joosten - 

Ella Slutsky - Scientist, Institute of Biochemistry, Moscow


Other Members:

Adrienne Lloyd (High School Student) - 

Aaron Mohrenweiser (High School Student) -

Matt Romberg (High School Teacher) - 

 

Lloyd Lab


Postdoctoral Fellows:

Irina Bogdarina - Scientist, William Harvey Research Institute, UK

Parvathi Chary - 

Elliot Gruskin - 

Manorama Kanuri - Professor, Agriculture U. of Hyderabad, India

Colleen Piersen - 

Surendran Rajendran - 

Agustinus Rinaldy - 


Graduate Students:

Sarah Burgess - Clinical Coordinator, Baylor U.

Russ Carmical - Assistant Professor, UTMB

Diane Dowd - 

John Garvish - 

Elliott Gruskin -

Richard Hamilton - 

Gary Latham - 

Katherine A. Latham - 

Oleg Lavruhkin - 

Raymond Manuel - Associate Director of Clinical Trial Mangement, Boehringer Ingelheim Pharmaceuticals, Inc.

Michael McCarthy - 

Andy McNees - Faculty, UTMB

Courtney Nickell -

Simon Nyaga - 

Adrian Recinos -

David Rodriguez - Clinical Resident, U. Texas El Paso

Robert Schrock - 

Bin Sun -

Debra Vasquez - 

 

Research Assistants/Associates:

MaryLou Augustine - 

Eva Forgacs - 

Melissa Prince -

 

(Did we forget something/someone?  Help us keep this updated!)