Lloyd-McCullough Group Members
Dr. Irina Minko, Staff Scientist
Irina attended the Moscow State University and the Institute of Biochemistry of Russian Academy of Sciences. In 1999, she joined the Lloyd lab at the University of Texas Medical Branch in Galveston, Texas and continued her research when the lab transitioned to OHSU, Portland. Irina's work has been developed in the following directions: (i) The biochemical and cellular processing of DNA-protein cross-links; (ii) The role of specialized DNA polymerases in the bypass of DNA lesions; and (iii) The mutagenic consequences of cellular processing of damaged DNA. Currently, the main focus of Irina's research is on repair of DNA-DNA cross-links.
Dr. Anuradha Kumari, Senior Research Associate
Dr. Kumari received her PhD degree in 2004 from the Institute for Cancer Studies at University of Sheffield in the United Kingdom under the guidance of Dr. Thomas Helleday. Her PhD work focused on 1) studying thymidine-induced recombination intermediate generated at stalled replication forks, and 2) understanding the protective roles of p53 and TLS polymerases (eta and iota) at stalled replication forks. In 2005, she came to the US as a postdoctoral trainee in the lab of Dr. Hua Lu in the Dept. of Biochemistry and Molecular Biology (OHSU), where she worked on identifying the role of a chromatin associated protein, SSRP1, in homologous recombination-mediated repair in conjunction with another recombination-associated protein, Rad54. In 2007, she joined the Lloyd and McCullough lab where she has been involved in multiple projects relevant to cellular DNA damage responses invoked by DNA-DNA and DNA-protein crosslinking agents. Two of the ongoing projects utilize E. coli models to study the contribution of DNA repair helicases and polymerases in response to DNA damaging agents, such as formaldehyde, Mitomycin C, and ultra-violet rays. The other two projects involve cell culture systems and are focused on understanding the repair mechanisms associated with formaldehyde-induced DNA damage. In her spare time, she enjoys nature photography, and working with beads and stones (i.e., jewelry making in case you have not guessed it!).
Dr. Harini Sampath, Postdoc
Harini Sampath completed her doctoral training in Biochemical and Molecular Nutrition at the University of Wisconsin-Madison in 2008. Having obtained extensive training in lipid and carbohydrate metabolism and ER stress pathways in the development of obesity, Dr. Sampath joined the Lloyd lab in 2009. She is currently interested in delineating the molecular pathways leading to metabolic dysfunction in mice deficient in the DNA glycosylase, NEIL1. Her studies are particularly focused on understanding the relationships between oxidative stress, mitochondrial dysfunction, and metabolic syndrome. In her free time, Harini enjoys traveling and developing recipes for her vegetarian food blog.
Dr. Aaron Jacobs, Postdoc
Aaron attended Harvey Mudd College in Claremont, CA where he learned mechanistic and synthetic chemistry under the guidance of Dr. Bill Daub. He moved out East to Johns Hopkins University in Baltimore, MD where he used synthetic organic chemistry to tackle questions about DNA damage and repair in the lab of Dr. Marc Greenberg. In June, 2010 graduated with the PhD dissertation "Strand Scission from a Nucleobase Radical (and) Bypass and Repair of C4'-Oxidized Abasic Lesions." Aaron moved back West with his wife Allison to join the Lloyd and McCullough labs and currently works on multiple projects pertaining to DNA repair, including use of high throughput assays to identify small molecule inhibitors of glycosylases. Aaron's hobbies include hiking, camping, and raquetball, and like all good chemists he loves to cook. He hails from Sacramento, CA and foolishly believes one day the Sacramento Kings will be respectable again, although the scientist in him requires further evidence.
Dr. Marcus Calkins, Postdoc
Marcus grew up in Oregon, but moved to Wisconsin where he received a degree in Molecular and Environmental Toxicology from University of Wisconsin-Madison in 2008. His early studies focused on mechanisms of protection from oxidative insults, culminating in a thesis which involved stimulation of Antioxidant Response Element mediated transcription to provide prophylactic protection from neurotoxins. After receiving his degree, he returned to Oregon to study mitochondrial involvement in the progression of Alzheimer's disease. He then changed focus to join the Lloyd-McCullough lab in 2011 to work on UV damage response. (He is especially interested in methods to increase repair of UV damaged DNA.) In his free time, Marcus enjoys the high quality of life that living in Portland affords, with a special love for being able to drink the tap water.
Dr. Richard Kleinschmidt, Senior Research Assistant
Richard received his PhD in molecular biology/genetics from Louisiana State University in 2011 under the guidance of Dr. David Donze. His graduate work mainly focused on gene regulation through chromatin boundary elements in S. cerevisiae. Prior to graduate school, he worked as a research technician at Emory School of Medicine in Atlanta, GA and Children's Hospital for Research Institute in New Orleans, LA. He moved to Oregon last year and is now working with yeast in the Lloyd/McCullough lab to determine the gene pathways responsible for formaldehyde-induced DPCs (DNA-protein crosslinks) and subsequent mechanisms of DNA repair. Richard enjoys living in Portland and everything the Pacific Northwest has to offer.
Stacey Lin, Graduate Student
Stacey grew up in Taiwan, where she received her Bachelor's degree in Forestry from National Taiwan University. After receiving her degree, she worked as a technician at the University of Pittsburgh where she grew to enjoy molecular biology in the lab of Dr. Tawbi. She came to Portland in 2010 for the PMCB program at OHSU, where she joined the Lloyd-McCullough lab. Her current work focuses on repair glycosylases and polymerases. She is interested in the mutagenic spectrum of aflatoxin and the ability of cells to bypass and repair the lesion. When not in lab, Stacey enjoys hiking, music and trying new foods from a variety of cuisines.
Eleonora Juarez, Gruaduate Student
Ellie is from Monterrey, Mexico and grew up in Brownsville Texas. She received her Bachelors of Science in Biology from The University of Texas at Brownsville. She came to Portland in the fall of 2011 and joined the PMCB program at OHSU. She is currently a graduate student in the Molecular and Medical Genetics Department and a member of the McCullough-Lloyd lab. Her current work focuses on the importance of chromatin remodeling for the processing of DNA-protein crosslinks induced by formaldehyde exposure. When not in lab she loves exploring new cuisines and restaurants in around the Pacific Northwest, and attending all sorts of sports events. GO SPURS GO!
Dr. Vladimir Vartanian, Research Technician
Vladimir received a PhD degree in Linguistics from the Institute of Linguistics at the Russian Academy of Sciences in Moscow. His interests focused on the psychological and social aspects of language. He became interested in biological research and joined the lab in 2003. He currently studies the role of oxidative stress and was first to observe the metabolic syndrome in NEIL1 deficient mice. In his free time, Vladimir enjoys creating art with an emphasis on drawing and painting. Selections of his work are available for purchase through Forever Art.
Amber Bannon- OHSU Program in Molecular and Cellular Biosciences (Rotation)
Former Lab Members
M.L. "Buddy" Dodson -
Valeri Kossykh -
Adam Clore - Scientist, Integrated DNA Technologies
Paul House -
Jodi Johnson - Postdoc, Northwestern U.
Ana Sanchez - Professor, Department of Chemistry at Galveston College
Afsaneh Tavana - Professor, Tehran U., Iran
Tatyana Ustinnikova - Senior Res. Scientist, Russian Acad. Sciences
Randy Walker - Scientist, Perkin Elmer
Bendert de Graaf - Project Manager, Vitens
Priscilla Fernandes - Assistant Laboratory Director, Myriad Genetics
Andy Kurtz - Science Policy Fellow, NIH
Yun Xin Lim - Covance Inc
Khoa Nguyen - Postdoc, Harvard Medical School
Brie Schaeffer -
Kinrin Yamanaka - Postdoc, MIT
Heather Bassett -
Lauriel Earley - Graduate Student, OHSU (Grompe Lab Rotation)
Mike Harbut - Graduate Student, U. Penn
Ritche Jabil -
Alex Klug -
Brian Lowell - Medical Student, OHSU
Michael Meador -
Daun Milligan -
Laura Roy -
Olga Ryabinina - Research Associate, OHSU (Iordanov Lab)
Steve Wooden -
Hongbing Zhu -
Ashley Bynum -
Cristian Dan -
Tammy Luoh -
Megan Macfarlane -
Kaki Marshall -
Chelsea Mayo -
Rebecca Smith -
John Stewart -
Jeff Zhou -
International Visiting Students:
Erik Bom - Student, MSc Drug Discovery and Safety
Vincent de Maat -
Esmee Joosten -
Ella Slutsky - Scientist, Institute of Biochemistry, Moscow
Adrienne Lloyd (High School Student) -
Aaron Mohrenweiser (High School Student) -
Matt Romberg (High School Teacher) -
Irina Bogdarina - Scientist, William Harvey Research Institute, UK
Parvathi Chary -
Elliot Gruskin -
Manorama Kanuri - Professor, Agriculture U. of Hyderabad, India
Colleen Piersen -
Surendran Rajendran -
Agustinus Rinaldy -
Sarah Burgess - Clinical Coordinator, Baylor U.
Russ Carmical - Assistant Professor, UTMB
Diane Dowd -
John Garvish -
Elliott Gruskin -
Richard Hamilton -
Gary Latham -
Katherine A. Latham -
Oleg Lavruhkin -
Raymond Manuel - Associate Director of Clinical Trial Mangement, Boehringer Ingelheim Pharmaceuticals, Inc.
Michael McCarthy -
Andy McNees - Faculty, UTMB
Courtney Nickell -
Simon Nyaga -
Adrian Recinos -
David Rodriguez - Clinical Resident, U. Texas El Paso
Robert Schrock -
Bin Sun -
Debra Vasquez -
MaryLou Augustine -
Eva Forgacs -
Melissa Prince -
(Did we forget something/someone? Help us keep this updated!)