Lein Lab Publications

Pancorbo OC, Lein PJ and Blevins RD (1987) Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility. Arch Environ Contamin Toxicol 16:531-537.

Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ and Roth JA (1988) Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fund Appl Toxicol 11:519-527.

Lein PJ and Higgins D (1989) Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in vitro. Dev Biol 136:330-345.

Bruckenstein DA, Lein PJ, Higgins D and Fremeau RT (1990) Distinct spatial localization of mRNA's in cultured sympathetic neurons. Neuron 5:809-819.

Lein PJ, Higgins D, Turner DC, Flier LA and Terranova VP (1991) The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the a1b1 integrin. J Cell Biol 113:417-428.

Lein PJ and Higgins D (1991) Protein synthesis is required for the initiation of dendritic growth in embryonic rat sympathetic neurons in vitro. Dev Brain Res 60:187-196.

Lein PJ, Banker GA and Higgins D (1992) Laminin selectively enhances axonal growth and acceler-ates the development of polarity by hippocampal neurons in culture. Dev Brain Res 69:191-197.

Craig DK, Davis JS, Lee LG, Lein PJ and Hoffman PW (April 1993) Toxic Chemical Risk Acceptance Guidelines for Use in DOE Facilities. WSRC-MS-92-206-Rev 1.

Lein PJ, Johnson M, Guo X, Rueger D, and Higgins D (1995) Osteogenic protein-1 (OP-1) induces dendritic growth in rat sympathetic neurons. Neuron 15:597-605.

Lein PJ and Higgins D (1996) Antibodies to b1 integrins inhibit dendritic growth in rat sympathetic neurons. Biomedical Res 7:101-112.

Lein P, Guo X, Hedges AM, Rueger D, Johnson M, and Higgins D (1996) The effects of extracellular matrix and osteogenic protein-1 on the morphological differentiation of rat sympathetic neurons. Intl J Develop Neurosci 14:203-215.

Guo X, Metzler-Northrup J, Lein P, Rueger D, and Higgins D (1997) Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons. Dev Brain Res104:101-110.

Gadient RA, Lein P, Higgins D, and Patterson PH (1998) Effect of leukemia inhibitory factor (LIF) on morphology and survival of hippocampal neurons and glia cells. Brain Res 798:140-146.

Guo X, Chandrasekaran V, Lein P, Kaplan PL, and Higgins D (1999) Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons. J Neurosci 19:2113-2121.

Lein P, Gallagher PJ, Amodeo J, Howie H, Roth JA (2000) Manganese induces neurite outgrowth in PC12 cells via upregulation of av integrins. Brain Res 885:220-230.

Guo X, Lin Y, Horbinski C, Drahushuk K, Kim I-J, Kaplan PL, Lein P, Wang T, Higgins D (2001) Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity. J Neurobiol. 48:120-130.

Dattatreyamurty B, Roux E, Kaplan PL, Robak LA, Horbinski C, Lein P, Higgins D, Chandrasekaran V (2001) Cerebrospinal fluid contains biologically active bone morphogenetic protein-7. Exp Neurol. 172:273-281.

Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ * (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci. 2:12. http://www.biomedcentral.com/1471-2202/2/12/

Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD (2002) Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicol. 23:147-157.

Kim IJ, Beck HN, Lein PJ, Higgins D (2002) Interferon g Inhibits Dendritic Growth and Synapse Formation in Rat Sympathetic and Hippocampal Neurons. J Neurosci. 22:4530-4539.

Schuh RA, Lein PJ, Beckles RA, Jett DA (2002) Non-cholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein (CREB) in cultured neurons. Toxicol Appl Pharmacol. 182:176-185.

Lein P*, Beck HN, Chandrasekaran V, Gallagher PJ, Lin Y, Guo X, Hedges AM, Kaplan PL, Tiedge H, Higgins D (2002) Glia induce dendritic growth in cultured sympathetic neurons by modulating the balance between BMPs and BMP antagonists. J Neurosci. 22:10377-10387.

Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, Lein P, Chen HL, Hoffer BJ, Wang Y (2003) Intravenous administration of bone morphogenetic protein-7 after ischemia improves motor function in stroke rats. Stroke. 34:558-564.

Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ * (2003) PCBs induce caspase-dependent cell death in cultured hippocampal neurons. Toxicol Appl Pharmacol. 190:72-86.

Chen HL, Lein PJ, Wang, JY, Gash D, Hoffer BJ and Chiang YH (2003) Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopmaine-lesioned animals. Brain Res. 994:81-90.

Chen HL, Lein PJ, Wang, JY, Gash D, Hoffer BJ and Chiang YH (2003) Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopmaine-lesioned animals. Brain Res. 994:81-90.

Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ (2003) PCBs induce caspase-dependent cell death in cultured hippocampal neurons. Toxicol Appl Pharmacol. 190:72-86.

Fryer AD, Lein PJ, Howard AS, Yost B, Beckles RA, Jett DA (2004) Mechanisms of organophosphate insecticide-induced airway hyperreactivity. Am J Physiol. 286:L963-L969.

Kim IJ, Drahushuk KM, Kim WY, Lein P, Andres DA and Higgins D (2004) Extracellular signal-regulated kinases regulate dendritic growth in rat sympathetic neurons. J Neurosci. 24:3304-3312.

Lein, PJ and Fryer AD (2005) Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of Acetylcholinesterase inhibition. Toxicol Sci. 83:166-176.

Lein P, Goldberg A, Locke P, Silbergeld E (2005) In vitro and alternative approaches to developmental neurotoxicity testing (DNT). Environ Toxicol Appl Physiol.19:735-744.

Spencer PS and Lein PJ (2005) Neurotoxicity. In: Encyclopedia of Toxicology, 2nd edition (Wexler P, ed) Elsevier, Oxford, UK, pp. 206-218.

Howard AS, Bucelli R, Jett DA, Lein PJ (2005) Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol Appl Pharmacol. 207:112-124.

Jett DA and Lein PJ (2006) Non-cholinesterase mechanisms of central and peripheral neurotoxicity: Muscarinic receptors and other targets. In: Toxicology of Organophosphate & Carbamate Compounds (Gupta RC, ed) Elsevier, San Diego, CA. pp. 233-246.

Pin S, Chen HL, Lein PJ, Wang MM (2006) Nucleic acid binding agents exert local toxic effects on neurites via a non-nuclear mechanism J. Neurochem. 96:1253-1266.

Lein PJ, Mervis RF, Bachstetter AD, Yang D, Tilson HA, Harry GJ, Kodavanti PRS (In press) Ontogenetic alterations in the molecular and structural correlates of dendritic growth following developmental exposure to polychlorinated biphenyls. Environ Health Perspect.

Lein PJ and Fryer AD (In press) Autonomic and enteric neurons: Tissue Culture. In: Encyclopedia of Neuroscience, Elsevier, San Diego, CA.

Lein, P, Locke, P and Goldberg A (In press) Meeting Report: Alternatives for Developmental Neurotoxicity Testing – TestSmart Developmental Neurotoxicology. Environ Health Perspect.