Lein Lab Collaborations

Allison Fryer, Ph.D., Pharmacology and Physiology, OHSU
Mechanisms of organophosphate-induced airway hyperreactivity. The goal of this collaborative project is to determine how organophosphate pesticides alter M2 muscarinic receptors expressed by parasympathetic nerves in the airways to cause airway hyperreactivity.

SUNY at Buffalo
Molecular mechanisms underlying dendritic growth. This is a long-standing collaboration that has focused on identifying the signaling pathways by which BMPs trigger dendritic growth in sympathetic neurons. More recently we have initiated a collaboration to investigate the hypothesis that the inflammatory cytokine, interferon-gamma, causes dendritic retraction via retrograde signaling.

Jack McCarthy, Ph.D., Biomedical Engineering, OGI School of Science & Engineering
Sensor microarray-chip hybrids for accelerated research and development on the simultaneous detection of multiple analytes. We are working together to determine if microarray-chip hybrids can be optimized for use as a biosensor for organophosphate pesticides in environmental samples.

Isaac Pessah, Ph.D., Biochemistry and Molecular Biology, UC Davis
Models and mechanisms of PCB developmental neurotoxicity. This project combines Dr. Pessah's expertise in biochemistry and electrophysiology with our expertise in primary neuronal cell culture and dendritic growth to test the hypothesis that PCB perturbation of ryanodine receptor (RyR) function disrupts critical neurodevelopmental events in the intact brain resulting in altered neuronal connectivity.

University of Michigan
Molecular mechanism of dendritogenesis. This collaboration builds on Dr. Wang's expertise in molecular biology and interest in transcription factor regulation and our knowledge of dendritic growth in cultured sympathetic neurons to identify the genes that control the initial stages of dendritic growth.