Robert Irwin, M.D., MPH
Senior Investigator, Laboratory of Dr. Charles Allen
Research Interests:
- Neuroscience/Neuropharmacology
- Occupational & Environmental Medicine
- Public Health
- Imaging of Intracellular Ions
- Pharmacokinetics/Pharmacodynamics Modeling
- Neurosteroids
- Neurodegenerative Disease
Education:
B.S. Chemistry, Portland State University, Portland, OR, 1980
M.D. Oregon Health & Science University, Portland, OR, 1985
M.P.H. Oregon Health & Science University, Portland, OR, 1999
Professional Experience:
3/80 - 9/81 Research Faculty, Portland State University, Portland, Oregon
6/85 - 6/88 Internal Medicine Internship & Residency, Providence Medical Center, Portland, Oregon.
9/88 - 6/89 Clinical Neuropharmacology Fellowship, Dept. of Neurology, Oregon Health Sciences University Portland, Oregon.
7/89 - 6/91 National Institutes of Health, Pharmacology Research Associate (PRAT Fellowship), National Institute of General Medical Sciences, Bethesda, Maryland.
7/91 - 3/94 National Institutes of Health Pharmacology Fellowship, National Institutes of Health, Bethesda, Maryland.
4/94 - 6/97 Assistant Professor, Departments of Pharmacology and Toxicology, Medicine and Neurology, Indiana University School of Medicine, Indianapolis, Indiana.
7/97 - 6/99 Internal Medicine Fellowship: VA Medical Center / Oregon Health Sciences University, Portland, Oregon.
7/99 – present Consulting Internal Medicine Practice, Portland, Beaverton & Salem Oregon.
3/02 – present Senior Investigator, Center for Research on Occupational and Environmental Toxicology, Oregon Health & Sciences University
Selected Publications:
R.P. Irwin, C.N. Allen. Effects of baclofen and nociceptin/orphaninFQ on presynaptic calcium transients in retinohypothalamic tract terminals of the suprachiasmatic nucleus. #285.11. 2003 Abstract: Society for Neuroscience, 2003.
Inorganic Pi increases neuronal survival in the acute early phase following excitotoxic/oxidative insults. M. Glinn, B. Ni, R. P. Irwin, S. W. Kelley, S-Z. Lin and S. M. Paul, J. Neurochem. 70:1850-1858, 1998.
Regulation of endothelial cell myosin light chain phosphorylation and permeability by vanadate. Gilbert-McClain LI; Verin AD; Shi S; Irwin RP; Garcia JG. J Cell Biochem 70:141-155, 1998.
Role of tyrosine phosphorylation in thrombin-induced endothelial cell contraction and barrier function. Shi S; Verin AD; Schaphorst KL; Gilbert-McClain LI; Patterson CE; Irwin RP; Natarajan V; Garcia JG: Endothelium 6:153-171, 1998.
Mastoparan-induced apoptosis of cultured cerebellar granule neurons is initiated by calcium release from intracellular stores. S.-Z. Lin, G.-M. Yan, K. E. Koch, S. M. Paul, and R. P. Irwin. Brain Research 771:184-195, 1997.
Carbamazepine inhibition of NMDA-evoked calcium influx in rat cerebellar granule cells. C. J. Hough, R. P. Irwin, X.-M. Gao, M. A. Rogawski, D.-M. Chuang. J. Pharmacol. Exp. Ther. 276:143-149, 1996.
Activation of G-proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons. G-M. Yan, S-Z. Lin, R. P. Irwin and S. M. Paul. J. Neurochem. 65:2425-2431, 1995.
Diphenylhydantoin induces apoptotic cell death of cultured rat cerebellar granule neurons. G-M. Yan, R. P. Irwin, S-Z. Lin, M. Weller, K. A. Wood and S. M. Paul. J. Pharmacol. Exp. Ther. 274:983-990, 1995.
Characterization of the excitoprotective actions of n-methyl-d-aspartate in cultured cerebellar granule neurons. P. Damschroder-Williams, R. P. Irwin, S-Z. Lin and S. M. Paul. J. Neurochem. 65:1069-1076, 1995.
Activation of muscarinic cholinergic receptors block apoptosis of cultured cerebellar granule neurons. G-M. Yan, S-Z. Lin, R. P. Irwin and S. M. Paul. Mol. Pharm. 47:248-257, 1995.
Steroid potentiation and inhibition of n-methyl-d-aspartate receptor-mediated intracellular Ca2+ responses: structure-activity studies. R. P. Irwin, S-Z. Lin, M. A. Rogawski, R. H Purdy and S. M. Paul. J. Pharmacol. Exp. Ther. 271:677-682, 1994.
N-methyl-d-aspartate induces a rapid, reversible and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons. R. P. Irwin, S. Lin, R. T. Long and S. M. Paul. J. Neuroscience 14:1352-1357, 1994.
Methods to facilitate early exploratory testing of novel psychopharmacologic agents in humans. W. Z. Potter, R. P. Irwin, Clinical Pharmacology in Psychiatry, Ed. Gram et al., Springer-Verlag, Berlin, Heidelberg, 1993.
Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in rat hippocampal neurons. R. P. Irwin, N. J. Maragakis, M. A. Rogawski, R. H. Purdy, D. H. Farb, and S. M. Paul. Neurosci. Lett. 141:30-34, 1992.
Principles of neuropharmacology (II) synaptic transmission, J. G. Nutt, R. P. Irwin, Textbook of Clinical Neuropharmacology and Therapeutics, 2nd Ed., Klawans et al. ed., Raven Press, Ltd, N.Y. p15-22, 1992.
Principles of neuropharmacology (I) pharmacokinetics and pharmacodynamics, R. P. Irwin, J. G. Nutt. Textbook of Clinical Neuropharmacology and Therapeutics, 2nd Ed., Klawans et al. ed., Raven Press, N.Y. p1-14, 1992.
Pharmacodynamics of the hypotensive effect of levodopa in Parkinsonian patients. R.P. Irwin, J.G. Nutt, W.R. Woodward, S.T. Gancher. Clinical Neuropharm. 15:365-374, 1992.
