OHSU

Laboratory of Dr. Charles Allen

Patched cell


Research Interests

The long-term goal of our research is to understand the functional properties of SCN neurons and how the circadian clock regulates these properties. To reach this goal we are pursuing four lines of research (click for a summary of our work in these areas): 

Cellular electrophysiology of the suprachiasmatic nucleus

Regulation of retinal input to the SCN

Role of intracellular Ca2+ as a signaling molecule in the circadian system

Characterization of the retinal ganglion cells projecting to the SCN

 

Publications

Find Dr. Allen's publications on PubMed

 

Lab Members

 

 

Robert Irwin, M.D., MPHRobert Irwin, M.D., MPH
Senior Investigator

Dr. Irwin received his Bachelor of Science in Chemistry from Portland State University and his M.D. and M.P.H. from Oregon Health & Science University, Portland, Oregon. Dr. Irwin is using cellular imaging techniques to study the role of calcium signaling in the suprachiasmatic nucleus. More information.

 

 

 

 

Mykhalo MoldavanMykhaylo Moldavan, Ph.D.
Senior Research Associate

Dr. Moldavan received his Bachelor of Science in Biology from Kyiv State University in Kyiv, Ukraine and his Ph.D in Physiology from the Bogomoletz Institute of Kyiv, Ukraine. He is studying the modulation, by presynaptic receptors, of optic nerve signaling to the suprachiasmatic nucleus. More information.

 

 

Michelle Sorensen, B.A.  

Research Assistant & Technician

Michelle Sorensen

Michelle received her Bachelor of Arts in Biology from the Robert D. Clark Honors College at the University of Oregon.  She joined the lab in 2009.  Michelle's main areas of expertise include molecular biology, cell and tissue culture, and animal colony management.  She is currently working with Dr. Irwin to develop a method to study neurons of the suprachiasmatic nucleus in dissociated cultures.  She is also developing a protocol to perform in situ hybridization in mouse and rat brain, with particular emphasis on area of the suprachiasmatic nucleus.  Michelle also maintains our transgenic mouse and rat colonies. More information.


 


 

Allen Lab Summer 2010
The Allen Lab, Summer 2010. From Left: Michelle Sorensen, Celine Croft (summer intern), Chuck Allen, Misha Moldavan, Robert Irwin
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