Stefanie Kaech Petrie, Ph.D.

Research Interests

The first time I watched a time-lapse recording of a living cell I became fascinated by the power of digital microscopy.  The discovery of GFP and its application to visualize dynamic events inside of cells has revolutionized modern cell biology.  I first used this enabling technology to study the structural proteins that give a neuron its shape and moved on to study membrane protein trafficking when I arrived in Portland. In my current role as the Director of the Advanced Light Microscopy Core I get to discuss imaging projects with students, postdoc and faculty, teach them the use of the high-end equipment in the Core, and share their excitement when the images obtained are revealing for their research. 

Biography

Dr. Kaech Petrie obtained her Ph.D. in Cell Biology in 1991 at the University of Basel, Switzerland. After a short post-doctoral experience at NINDS-NIH in Bethesda, Maryland, she joined the laboratory of Dr. Andrew Matus at the Friedrich Miescher Institute in Basel, Switzerland, where she specialized in visualization of dynamic processes in living cells using GFP, a technology just emerging at that time.  She joined Dr. Gary Banker's laboratory at OHSU in 2000 and transitioned to become the Director of the Advanced Light Microscopy Core @ The Jungers Center in 200.

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Links

Selected Publications

Kaech S, Banker G (2007) Culturing hippocampal neurons. Nat Protoc 1:2406-15.

Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K, Langeberg LK, Banker G, Raber J, Scott, (2007) A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci. Jan 10;27(2):355-65. Abstract

Wayman GA, Kaech S, Grant WF, Davare M, Impey S, Tokumitsu H, Nozaki N, Banker G, Soderling TR. (2004) Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci. Apr 14;24(15):3786-94. Abstract

Sampo B, Kaech S, Kunz S, Banker G. (2004Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci. Apr 14;24(15):3786-94. Abstract

Silverman M. A., Kaech S., Jareb M., Burack M. A., Vogt L., Sonderegger P., and Banker G. (2001) Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture. Proc Natl Acad Sci 98, 7051-7057. Abstract

Kaech S, Parmar H., Roelandse M., Bargmann C., Matus A. (2001) Cytoskeletal microdifferentiation: A mechanism for organizing morphological plasticity in dendrites. Proc Natl Acad Sci 98, 7086-7092. Abstract

Fischer M., Kaech S., Wagner U., Brinkhaus H., Matus A. (2000) Glutamate receptors regulate actin-based plasticity in dendritic spines. Nat Neurosci 3, 887-94. Abstract