Faculty & Staff
Peter Spencer, PhD, FANA, FRCPath
- Professor of Neurology, OHSU School of Medicine
- Senior Scientist, OHSU Center for Research on Occupational & Environmental Toxicology
- Member and Former Director, OHSU Global Health Center.
Dr. Spencer holds six honorary professorial appointments at foreign institutions, including the Chinese Center for Disease Control and Prevention (Beijing), and Fudan (Shanghai) and Sichuan (Chengdu) universities. An Emeritus Member of the American Society of Toxicology (2011), he gave the 2013 Hooisma Lecture in Neurotoxicology and the 2010 Keynote Lecture for the Society of Toxicologic Pathology and International Federation of Societies of Toxicologic Pathologists (Encomium by B. Bolon, Toxicol. Pathol. 39:15-18, 2011). He is an Honorary Member of the Indian Academy of Neurosciences (2005); recipient of the 2003 Distinguished Service Award, African Society of Toxicological Sciences; the 2002 Distinguished Scientist Award in Neurotoxicology, American Society of Toxicology; the 1998 Alzheimer's Association Brumback Award for Outstanding Achievement in Research; the 1997 Snider Foundation Award for Lifetime Contributions to Toxicology, and the 1997 Silvio O. Conte prize for basic and applied neuroscience contributions relevant to environmental health. Other honors include: Weil Awardee and Moore Awardee of the American Association of Neuropathologists; Member, American Neurological Association, and Fellow, Royal College of Pathologists (UK). National and international named visiting professorships and lectureships include: Alice B. Hamilton Lecturer, George H. Germann Memorial Lecturer, Sibte Hasan Zaidi Orator, Ellerman Lecturer, Hanninen Lecturer, Kugelberg Lecturer, Grass Traveling Neuroscience Lecturer, Sterling Visiting Professor, Sitlington Lecturer in Toxicology, and Tarbox Distinguished Neurosciences Lecturer.
Current Research Interests
Etiology, systems biology and prevention of neurotoxic and neurodegenerative disease.
"The Poison that Waits?", BBC Documentary describing research on western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia syndrome.
BOOKS (selected from 7)
Spencer and Schaumburg's Experimental and Clinical Neurotoxicology, Williams & Wilkins (1980) & Oxford (2000).
First edition (1980) (temporarily unavailable)
Second edition (1310 p, 2000) Chinese Translation (Ch. 1-3 only)
PAPERS (selected from 390)
Molecular Mechanisms of Neurotoxic Disease
Spencer, P.S., Fry, R.C. and Kisby, G.E. Unraveling 50-year-old clues linking neurodegeneration and cancer to cycad toxins: Are microRNAs common mediators? Frontiers in Genetics 2012;3:192. doi: 10.3389/fgene.2012.00192. Epub 2012 Sep 28.
Spencer P.S. , Fry R.C., Palmer V. and Kisby G.E. Western Pacific ALS=PDC: a prototypical neurodegenerative disorder linked to DNA damage and aberrant proteogenesis? Frontiers in Neurology2012;3:180. doi: 10.3389/fneur.2012.00180. Epub 2012 Dec 21.
Kisby, G.E., Spencer, P.S. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? International Journal of Environmental Research and Public Health 2011, 8, 3889-3921; doi:10.3390/ijerph8103889.
Tshala-Katumbay D, Desjardins P, Sabri P, Butterworth R, and Spencer P. New insights into mechanisms of gamma diketone-induced axonopathy. Neurochemical Research 34:1919-23, 2009.
Tshala-Katumbay, D., Monterroso, V., Kayton, R., Lasarev, M.,? Sabri, M. and Spencer, P. Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. Toxicological Sciences 107:482-9, 2009.
Field and Epidemiological Studies of Environmental Neurological Disease
Spencer, P.S., Vandemaele, K., Richer, M., Palmer, V.S., Chungong S., Anker, M., Ayana, Y., Ayana, Y., Opoka, M.L, Klaucke, D.N, Quarello and Tumwine, J.K. Nodding Syndrome in Mundri County, South Sudan: Environmental, nutritional and infectious factors. African Health Sciences, 13:183-203, 2013.
Spencer, P.S., Palmer, V.S. and Jilek-Aall, L. Nodding Syndrome: Origins and natural history of a longstanding epileptic disorder in sub-Sahara. African Health Sciences 13:176-82, 2013.
Spencer, P.S. and Palmer, V.S. Interrelationships of undernutrition and neurotoxicity: food for thought and research attention. Neurotoxicology 22:605-16, 2012.