Peter Spencer, PhD, FRCPath
- Email:
- spencer@ohsu.edu
- Position:
- Professor of Neurology, OHSU School of Medicine
- Senior Scientist, OHSU Center for Research on Occupational & Environmental Toxicology
- Director, OHSU Global Health Center.
Read more about Dr. Spencer's research
Research Interests
Etiology and systems biology of neurotoxic and neurodegenerative disease
Biography
Dr. Spencer received his doctoral degree from the University of London, Faculty of Medicine (Pathology) and postdoctoral training in neuroscience in the Rose F. Kennedy Center for Research on Mental Retardation and Human Development of the Albert Einstein College (AECM) of Medicine. One of five national Joseph P. Kennedy, Jr., Fellows in the Neurosciences (1974-76), he rose to tenured Professor of Neuroscience, Neurology and Pathology, and founding director of the Institute of Neurotoxicology. In 1988, he joined Oregon Health & Science University to found the Center for Research on Occupational and Environmental Toxicology. He has served as Principal Investigator on numerous federal individual, program project and center grants.
Dr. Spencer holds six honorary professorial appointments at foreign institutions, including the Chinese Center for Disease Control and Prevention, and Fudan and Sichuan universities. He is 2005 Honorary Member of the Indian Academy of Neurosciences; recipient of the 2003 Distinguished Service Award, African Society of Toxicological Sciences; the 2002 Distinguished Scientist Award in Neurotoxicology, American Society of Toxicology; the 1998 Alzheimer's Association Brumback Award for Outstanding Achievement in Research; the 1997 Snider Foundation Award for Lifetime Contributions to Toxicology, and the 1997 Silvio O. Conte prize for basic and applied neuroscience contributions relevant to environmental health. Other honors include: Weil Awardee and Moore Awardee of the American Association of Neuropathologists; Member, American Neurological Association, and Fellow, Royal College of Pathologists, U.K. National and international named visiting professorships and lectureships include: Alice B. Hamilton Lecturer, George H. Germann Memorial Lecturer, Sibte Hasan Zaidi Orator, Ellerman Lecturer, Hanninen Lecturer, Kugelberg Lecturer, Grass Traveling Neuroscience Lecturer, Sterling Visiting Professor, Sitlington Lecturer in Toxicology, and Tarbox Distinguished Neurosciences Lecturer.
Dr. Spencer holds six honorary professorial appointments at foreign institutions, including the Chinese Center for Disease Control and Prevention, and Fudan and Sichuan universities. He is 2005 Honorary Member of the Indian Academy of Neurosciences; recipient of the 2003 Distinguished Service Award, African Society of Toxicological Sciences; the 2002 Distinguished Scientist Award in Neurotoxicology, American Society of Toxicology; the 1998 Alzheimer's Association Brumback Award for Outstanding Achievement in Research; the 1997 Snider Foundation Award for Lifetime Contributions to Toxicology, and the 1997 Silvio O. Conte prize for basic and applied neuroscience contributions relevant to environmental health. Other honors include: Weil Awardee and Moore Awardee of the American Association of Neuropathologists; Member, American Neurological Association, and Fellow, Royal College of Pathologists, U.K. National and international named visiting professorships and lectureships include: Alice B. Hamilton Lecturer, George H. Germann Memorial Lecturer, Sibte Hasan Zaidi Orator, Ellerman Lecturer, Hanninen Lecturer, Kugelberg Lecturer, Grass Traveling Neuroscience Lecturer, Sterling Visiting Professor, Sitlington Lecturer in Toxicology, and Tarbox Distinguished Neurosciences Lecturer.
Video
"The Poison that Waits?", BBC DocumentaryLinks
(Neuro)toxicogenomics and Child Health Research Center
Selected Publications
BooksExperimental and Clinical Neurotoxicology
(edited by Peter S. Spencer and Herbert H. Schaumburg)
First edition (1980) (entire contents of book available)
Second edition (2000)
Chinese Translation (Introductory Chapters)
Gene Expression in normal and toxic states
Beyer, R.P. et al. Multi-center study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analysis. Toxicological Sciences 99:326-27, 2007.
Bammler, T. et al Standardizing global gene expression analysis between laboratories and across platforms. Nature Methods 2:351-356, 2005.
Qin, L-X., Kerr, K.F. and Contributing Members of the Toxicogenomics Research Consortium Empirical evaluation of data transformations and ranking statistics for microarray analysis. Nucleic Acids Research 32:5471-5479, 2004.
Molecular Mechanisms of Neurotoxic Disease
Tshala-Katumbay D, Desjardins P, Sabri P, Butterworth R, and Spencer P. New insights into mechanisms of gamma diketone-induced axonopathy. Neurochemical Research 2009, April 29.
Tshala-Katumbay, D., Monterroso, V., Kayton, R., Lasarev, M., Sabri, M. and Spencer, P. Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. Toxicological Sciences 107:482-9, 2009.
Tshala-Katumbay, D., Monterroso, V., Kayton, R., Lasarev, M., Sabri, M. and Spencer, P.S. Probing mechanisms of axonopathy. Part I. Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene. Toxicological Sciences 105:134-41, 2008.
Sabri, M.I., Hashemi, S.B., Lasarev, M.R. and Spencer, P.S. Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport. Neurochemical Research 32:2152-9, 2007.
Tshala-Katumbay, D., Palmer, V.S., Lasarev, M.R., Kayton, R.J., Sabri, M.I. and Spencer, P.S. Monocyclic and dicyclic hydrocarbons: Structural requirements for proximal giant axonopathy. Acta Neuropathologica (Berl.) July 28 112:317-24, 2006.
Tshala-Katumbay, D.D., Palmer, V.S., Kayton, R.J., Sabri, M.I. and Spencer, P.S. A new murine model of giant proximal axonopathy. Acta Neuropathologica (Berl.) 109:405-410, 2005.
Zhan, C-G., Spencer, P.S. and Dixon, D.A. Chromogenic and neurotoxic effects of aliphatic γ-diketone: Computational insights into the molecular structures of mechanism. Journal of Physical Chemistry B 108:3098-6104, 2004.
Trimpin, S., Mixon, A.E., Stapels, M.D., Kim, M-Y., Spencer, P.S. and Deinzer, M.L. Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. Biochemistry 43:2091-2105, 2004.
Field and Epidemiological Studies of Environmental Neurological Disease
Spencer, P.S., Palmer, V.S. and Ludolph, A.C. On the decline and etiology of high-incidence motor system disease in West Papua (southwest New Guinea). Movement Disorders 20:S119-126, 2005.
Horner, R.D., Kamins, K.G., Feussner, J.R., Grambow, S.C., Hoff-Lindquist, J., Harati, Y., Mitsumoto, H., Pascuzzi, R., Spencer, P.S., Tim, R., Howard, D., Smith, T.C., Ryan, M.A.K., Coffman, C.J. and Kasarskis, E.J. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology 61:742-749, 2003.
McCauley, L.A., Lasarev, M.S., Sticker, D., Rischitelli, D.G. and Spencer, P.S. Illness experience of Gulf War veterans possibly exposed to chemical warfare agents. American Journal of Preventive Medicine 23:200-206, 2002.
Spencer, P.S., McCauley, L.A., Lapidus, J.A., Lasarev, M., Joos, S.K. and Storzbach, D. Self-reported exposures and their association with unexplained illness in a population-based case-control study of Gulf War Veterans. Journal of Occupational and Environmental Medicine 43:1041-1056, 2001.
