OHSU

Faculty & Staff

Glen E. Kisby, Ph.D.

Email:
kisby@ohsu.edu
Position:
Scientist (Associate Professor)
Graduate Faculty, Environmental and Molecular Toxicology, OSU
Office:
CROET 2590

PubMed Listing

Summary of Current Research

Research interests in my laboratory are focused on understanding the role of environmental and occupational chemicals in neurodegenerative disease. The large majority of chronic neurological disorders like Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) appear sporadically, suggesting the operation of environmental factor(s) in affected individuals. Ongoing studies are investigating the underlying molecular mechanisms of a prototypical progressive neurological disorder found in the western Pacific (ALS/PD complex) which has been shown to be strongly linked with prior exposure to a natural genotoxin [i.e., the cycad plant toxin methylazoxymethanol (MAM) b-D-glucoside]. We are also investigating the neurotoxic properties of similar genotoxins found in the North American environment. Of particular interest to our laboratory is determining whether genotoxins in our environment can induce a slow degeneration of post-mitotic neurons as seen in chronic neurological disorders. To test this hypothesis, we are examining the neurotoxic properties of various genotoxins (including MAM) in human neuroblastoma clones and transgenic animals which overexpress or are deficient in different DNA repair proteins. For comparison, studies are underway to characterize the type of DNA damage and the DNA repair capacity of nervous tissue from individuals with chronic neurodegenerative disease (e.g., ALS/AD complex, ALS, PD, and AD).

Recent Publications

Education

  • Ph.D., University of Texas at Austin, 1986
  • Research Associate, Institute of Neurotoxicology, Albert Einstein College of Medicine (New York)

Previous Positions

Non-Academic Interests