Emerging Technology Fund
Request for Applications
The goal of this Emerging Technology Fund (ETF) program is to provide funds for OHSU faculty to purchase equipment or technology needed to conduct state-of-the-art research. Examples could include instrumentation previously unavailable at OHSU, as well as the replacement of equipment that has become obsolete due to technical advances. Funds may be awarded to a group of investigators; a department, center, or institute or a university core facility. A requirement for successful funding will be a sound financial plan that ensures that major infrastructure elements, including space and personnel, would be provided from other sources for a minimum of 5 years.
The purpose of this program is to support emerging science by funding high-end instruments or technologies that will substantially advance OHSU research or keep it at the forefront of a particular research area. It is designed to support equipment that has few other mechanisms of support other than private philanthropy, and thus the minimum total cost of the equipment must be $400,000 or above (including necessary accessories).
Due date and other key dates
- Short letter of interest due September 15, 2016 (to help with reviewer recruitment).
- Applications due September 30, 2016.
- Review will occur in October 2016, with award notification by November 2016.
- Equipment must be purchased by April 30, 2017.
- Equipment must be received by June 30, 2017.
Any OHSU faculty member may apply.
- Funds are for equipment/technologies only.
- Applicants must include a detailed plan for the development and financial support of the infrastructure necessary to sustain the operation of the equipment and make it available to OHSU investigators. Note, however, that you are not required to place this instrument in a core.
- The program must serve major funded research programs (for example, P grants) or multiple (4 or more) federally (IDC-generating) funded investigators, but it should also be potentially available across OHSU. An annual progress report will be required.
- Documented support by potential users of the technology will be reviewed favorably.
Application and Budget Template
How many awards will be made in FY2017?
Funding is available for one award in FY2017. The fund size for FY2017 is $500,000; applications must request a minimum of $400,000. Total costs should include acquisition and expected costs of installation to make the equipment functional.
How are applications reviewed?
The ETF will be awarded through a competitive, peer-reviewed application process. Applications should emphasize why the emerging technology is critical to research at OHSU (see detailed instructions below). Applications will be submitted to the Office of the Senior Vice President for Research and reviewed by the OHSU Research Oversight Committee. Additional consultation with the University Shared Resources Program will be obtained as needed. Input from outside experts (e.g. OTRADI, ONAMI) with significant expertise in the new technology under consideration may be sought. The program will be reviewed annually by the OHSU Research Oversight Committee and the Office of the Senior Vice President for Research to determine whether benchmarks such as significant publications, new grants, and collaborations have resulted from the new technologies.What if I need instrumentation that costs less than $400,000?
The S10 mechanism is designed for equipment costing less than $500,000. Many scientists require such technologies, and institutional resources exist to help investigators apply for S10s. Sue Aicher is available to advise interested investigators about this grant mechanism. Equipment may also be requested through the normal capital budget process—e.g., working through your departments/units or through the Vice President for Research Office if the equipment is for a University Shared Resource.Can I group projects together to meet the $400,000 threshold?
Grouping less expensive instrumentation will not be seen as responsive.
OHSU's Emerging Technology Fund award has provided support for:
Michael Chapman, Ph.D., received funding in FY11 for an integrated system to measure the x-ray diffraction from crystalline samples of biological macromolecules–specifically, to measure diffraction and to elucidate atomic structures and analyze macromolecular interactions. The new instrumentation replaces obsolete equipment in the department of Biochemistry & Molecular Biology with state-of-the-art technology for the next decade.
Nabil Alkayed, M.D., Ph.D., received funding in FY11 for the Advanced Light Microscopy Core - a new in-vivo imaging system available to all OHSU researchers. This new technology takes advantage of advances in microscopy, laser technology, fluorescent dyes and transgenic animals which have made possible ultra-fast, deep-tissue, high-resolution dynamic imaging in live animals.
Paul Spellman, M.D., received funding in FY12 for a mass spectrometry-based flow cytometer to be integrated into the Flow Cytometry Core. The technology is capable of simultaneously analyzing 30+ channels with little overlap between the channels. Numerous groups on campus will benefit from this new technology, which will allow for data-based reconstruction of signaling networks, identification of stem cell signatures, cellular readouts of siRNA inhibition screens, and characterization of vesicle biogenesis.
Haining Zhong, Ph.D., received funding in FY12 for a high-pressure freezing and freeze substitution system to be housed at the immuno-electron microscopy core. Distortions and artifacts associated with conventional sample fixation and processing methods have become a major obstacle in microscopic studies of biological function and disease mechanisms. High-pressure freezing followed by freeze substitution is a state-of-the-art method to better preserve ultrastructural details in biological samples and is poised to emerge as s fundamental tool for fluorescence super-resolution microscopy.
Stephanie Kaech Petrie, Ph.D., received funding in FY13 to update and add new live-cell imaging equipment to the Advanced Light Microscopy Core at the Jungers Center. A new spinning disk confocal microscope will replace decade-old technology, offering increased color sensitivity, environmental control, a larger field-of-view, and the addition of an active illumination device. The core will also acquire an innovative device for live-cell imaging in a standard culture incubator. These two technologies are highly complementary and can be used in conjunction with one another to help researchers from various disciplines better understand cell and molecule behavior.
Eric Gouaux, Ph.D., received funding in FY14 to update the camera technology on OHSU's state-of-the-art Krios microscope. The new K2 Summit direct electron detector camera allows for measuring high resolution data for single particle cryo electron microscopy studies. The addition of the K2 camera will make a decisive difference in the research ability to capture 3-D images of complex protein structures.
Larry David, Ph.D., received funding in FY15 for a Thermo Scientific Q Exactive HF high-resolution mass spectrometer to enhance proteomics research at OHSU. The major function of the instrument is to perform targeted analyses to measure changes in protein abundance in complex cell and tissue lysates. Its placement in the Proteomics Shared Resource will help keep OHSU at the forefront of proteomics research, fulfill the needs of dozens of funded researches across the entire campus, and help accommodate the expanding research needs of the Knight Cardiovascular and Cancer Institutes.