Clinical Trials in Women's Health

Women's Health Research

The OHSU Women's Health Research Unit is actively recruiting patients for clinical trials in a variety of women’s health topics.

Current Clinical Trials in Contraception and Birth Control

COC+DHEA Study
The purpose of this study is to better understand taking a dietary supplement affects proteins in the blood when you are taking birth control pills. PI: Jeffrey Jensen MD, MPH eIRB #17651

Copper IUD Comparison Study
The purpose of this study is to investigate how an investigational copper IUD compares to the FDA approved ParaGard in patient satisfaction and preventing pregnancy. PI: Jeffrey Jensen MD, MPH eIRB #16899

Emergency Contraception and BMI
The purpose of this study is to improve the effectiveness of orally-dosed emergency contraceptives for women of higher BMIs. eIRB: 16291 PI: Alison Edelman, MD MPH

Implant-related Bleeding Study
The purpose of the study is to learn whether a medication called tamoxifen taken a few days per month can help reduce irregular bleeding in women who use the contraceptive implant (Implanon or Nexaplon). PI: Dr. Alison Edelman IRB: 16519

IUD Side Effects
The purpose of this study is to learn more about side effects and markers of stress in IUD users. PI: Nora Doty, MD eIRB #18244

TelAbortion Study
The purpose of this study is to assess service provision of medical abortion through telemedicine. eIRB #15974 www.telemedstudy.org

Vaginal Contraceptive Ring Study
The purpose of this study is to investigate how effective a new vaginal contraceptive ring is at preventing pregnancy. PI: Jeffrey Jensen MD, MPH eIRB #18041

Current Clinical Trials in Urogynecology

Estrogen Microbiome Study
The purpose of this study is to understand how the vaginal and urinary microbiomes change in response to estrogen. PI: Tom Gregory MD eIRB# 17056

Over Active Bladder: MRI Sub-Study
The purpose of this study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB) PI: Rahel Nardos, MD; co-PI: Lisa Karstens, PhD eIRB# 10729

Current Clinical Trials in Pregnancy and Infertility

Chronic Hypertension and Pregnancy
This study is being done to evaluate what the best, and safest treatment for mild chronic hypertension during pregnancy is for both mother and baby. PI: Leonardo Pereira, MD, MCR eIRB #17011

Eating Competence in Pregnancy
The purpose of this study is to learn more about the nutrition and diet composition of pregnant women and factors that influence the dietary choices they make during pregnancy. PI: Joyanna Hansen, PhD, RD, LD eIRB #18026

Functional Imaging of the Human Placenta by MRI
The purpose of this study is to use magnetic resonance imaging (MRI) to measure blood flow to the placenta during pregnancy. Maternal blood carries the oxygen and nutrients that the baby needs to grow and develop. This blood goes to the placenta which controls the exchange of nutrients to the baby and removal of waste products from the baby. The ability to look at blood flow whilst a baby is still in the womb will help obstetricians to find women who have poor blood flow (known as placental insufficiency) during pregnancy. Finding these potential problems during pregnancy, rather than delivery, may allow medical staff to intervene and give the best possible outcome for the baby. eIRB #15196, PI: Antonio Frias, MD

Maternal Body Composition Regulates Placental Function and Fetal Growth
The purpose of this research study is to learn more about how a pregnant woman’s body type (amount of muscle and fat) and food choices affect the nutrients transported from the placenta to the baby. We want to learn how this impacts the baby’s growth through the first year of life, and see if there are differences in growth between male and female babies. eIRB# 11175, PI: Nicole Marshall, MD, MCR

Maternal Well-Being Study
We are interested in working with pregnant women to promote well-being, support mothers and babies bonding, reduce stress, and support healthy fetal and infant brain development. PI: Kristen Mackiewicz Seghete, PhD eIRB #17203

Placenta Repository: A Study of Placental Function in Healthy and Pathological Pregnancies
Our long term goal is to identify pregnancies that are at risk of poor outcomes and to develop methods for prevention and treatment. eIRB # 16328; PI: Leonardo Pereira, MD

Randomized Trial of Magnesium Sulfate Dosing in Preeclampsia
The purpose of the study is to determine if an alternate magnesium sulfate dosing regiment in preeclamptic pregnant women with BMI > 35kg/m2 will result in a larger proportion of obese women who have therapeutic serum magnesium levels (>4.8 mg/dl) for seizure prophylaxis after 4 hours of administration and at the time of delivery. Kathleen Brookfield, MD, PhD eIRB #15809

Rosacea Course Fluctuations during Pregnancy: a Longitudinal Observational Study
The purpose of this study is to characterize the course of rosacea severity throughout pregnancy.<br />PI: Jon Hanifin, MD eIRB #16647

SCUBA Study
The purpose of this study is to learn more about a test that may be able to quickly identify women at risk of intra amniotic infection (IAI). PI: Dr. Leonardo Pereira, MD, MCR eIRB# 17000

VentFirst: A multicenter RCT of assisted ventilation during delayed cord clamping for micro-preemies
The purpose of this study is to determine whether delaying clamping of the umbilical cord up to 120 seconds and assisting breathing for extremely premature babies during that time reduces intraventricular hemorrhage (bleeding in the brain). PI: Jamie B. Warren, MD, MPH eIRB#15777

Current Clinical Trials in Menopause

Estrogen Microbiome Study
The purpose of this study is to understand how the vaginal and urinary microbiomes change in response to estrogen. PI: Tom Gregory MD eIRB# 17056

Over Active Bladder: MRI Sub-Study
The purpose of this study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB) PI: Rahel Nardos, MD; co-PI: Lisa Karstens, PhD eIRB# 10729

Treating Where it Hurts - Sexual Pain Study
The purpose of this study is to learn about the use of a low-dose estrogen cream applied in a new way to the vaginal entryway for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women. PI: Martha F. Goetsch MD, MPH eIRB# 16770

Clinical Trials in Heavy Menstrual Bleeding

ASTEROID 6: Uterine Fibroid Study
The purpose of this study is to understand the safety, side effects and efficacy of an investigational medication, Vilaprisan, compares to the standard of care for uterine fibroid treatment. PI: Jeffrey Jensen, MD, MPH eIRB #17289

Management of Pain from Endometriosis in Pre-Menopausal Women
The purpose of this study is to learn more about a new investigational medication in managing pain related to endometriosis.<br />PI: Jeffrey Jensen, MD, MPH eIRB #17289

Current clinical trials in Women's and Gynecologic Cancers 

In partnership with the Knight Cancer Institute

Find current trials involving ovarian, uterine and cervical cancers

Current Clinical Trials in other areas of women’s health

Biobehavioral Lactation Outcomes Following Oxytocin Administration During Parturition
The purpose of this study is to learn more about maternal hormone levels involved in lactation and their relationship to breastfeeding outcomes in women who received oxytocin as part of their birth experience compared to those who did not. Cathy L. Emeis, CNM, PhD, eIRB #15142