Clinical Trials in Women's Health

Women's Health Research

OHSU is actively recruiting patients for the clinical trials in the women’s health topics listed below.

Current Clinical Trials in Contraception and Birth Control

Combined Hormonal Contraception and Emergency Contraception Study
The purpose of this study is to determine if taking a birth control pill affects how well an emergency contraceptive pill, called Ulipristal Acetate (UPA), works. eIRB #11784, PI: Alison Edelman, MD

Pressure Dynamics in the Uterus
This is a research study comparing the pressure in the uterus in women with open or blocked fallopian tubes. eIRB# 11443, PI: Eva Patil, MD

Reducing Bleeding with the Hormonal IUD
The Women's Health Research Unit is recruiting for a clinical research study evaluating if a drug can help reduce irregular bleeding in women who are starting the hormonal IUD (Mirena or Liletta). eIRB #15881, PI: Jeffrey Jensen, MD.

TelAbortion Study
The purpose of this study is to assess service provision of medical abortion through telemedicine. eIRB #15974 www.telemedstudy.org

Understanding the Role of Cervical Mucus as Birth Control
This study examines cervical mucus and its role in providing birth control. This study also seeks to learn how hormonal medications can mirror the mucus changes during your natural cycle. Data from this trial will, potentially, help us design new non-hormonal contraceptives that use thickening of cervical mucus to prevent pregnancy. eIRB #11532, PI: Leo Han, MD

Current Clinical Trials in Urogynecology

Overactive Bladder Study
The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB; this study seeks to determine if bacteria in the urinary tract play a role in OAB. Rahel Nardos, MD; eIRB # 10729

Current Clinical Trials in Pregnancy and Infertility

Brain Complement and Preeclampsia
Our long term goal is to determine how immune factors contribute to brain inflammation and cardiovascular health in women affected by preeclampsia. Richard Burwick, MD eIRB #15344

Functional Imaging of the Human Placenta by MRI
The purpose of this study is to use magnetic resonance imaging (MRI) to measure blood flow to the placenta during pregnancy. Maternal blood carries the oxygen an nutrients that the baby needs to grow and develop. This blood goes to the placenta which controls the exchange of nutrients to the baby and removal of waste products from the baby. The ability to look at blood flow whilst a baby is still in the womb will help obstetricians to find women who have poor blood flow (known as placental insufficiency) during pregnancy. Finding these potential problems during pregnancy, rather than delivery, may allow medical staff to intervene and give the best possible outcome for the baby.  eIRB #15196, PI: Antonio Frias, MD

Maternal Body Composition Regulates Placental Function and Fetal Growth
The purpose of this research study is to learn more about how a pregnant woman’s body type (amount of muscle and fat) and food choices affect the nutrients transported from the placenta to the baby. We want to learn how this impacts the baby’s growth through the first year of life, and see if there are differences in growth between male and female babies. eIRB# 11175, PI: Nicole Marshall, MD, MCR

Myo-inositol in Pregnancy
Purpose of the study is to learn if myo-inositol supplements (supplement in the B-vitamin family) affect your blood sugar and how your body processes food for energy. eIRB #15080, PI: Amy M. Valent, DO

Optimizing Management of the Second Stage of Labor (OMSS): A Multicenter Trial
The purpose of this study is to assess the effectiveness of immediate pushing at complete cervical dilation on the rate of spontaneous vaginal delivery and pelvic floor muscle injury in nulliparous women. eIRB# 10411, PI: Aaron Caughey, MD, PhD

Randomized Trial of Magnesium Sulfate Dosing in Preeclampsia
The purpose of the study is to determine if an alternate magnesium sulfate dosing regiment in preeclamptic pregnant women with BMI > 35kg/m2 will result in a larger proportion of obese women who have therapeutic serum magnesium levels (>4.8 mg/dl) for seizure prophylaxis after 4 hours of administration and at the time of delivery. Kathleen Brookfield, MD, PhD eIRB #15809

Current Clinical Trials in Menopause

There are currently no clinical trials in this category available for enrollment. Please check back soon.

Clinical Trials in Menstruation

There are currently no clinical trials in this category available for enrollment. Please check back soon.

Current clinical trials in Women's and Gynecologic Cancers 

In partnership with the Knight Cancer Institute

Find current trials involving ovarian, uterine and cervical cancers

Current Clinical Trials in other areas of women’s health

Biobehavioral Lactation Outcomes Following Oxytocin Administration During Parturition
The purpose of this study is to learn more about maternal hormone levels involved in lactation and their relationship to breastfeeding outcomes in women who received oxytocin as part of their birth experience compared to those who did not. Cathy L. Emeis, CNM, PhD, eIRB #15142

Mindfulness-Based Group Cognitive Behavior Therapy for Women with Provoked Localized Vulvodynia
"Mindfulness-Based Group Cognitive Behavior Therapy for Women with Provoked Localized Vulvodynia (PLV)" is a study designed to learn more about the use of mindfulness based group cognitive behavior for PLV pain and anxiety. Participants will be randomized to one of two groups: mindfulness based cognitive behavior therapy or group education seminars. PI: Catherine Leclair, MD eIRB# 15221