Clinical Trials in Women's Health

Women's Health Research

OHSU is actively recruiting patients for the clinical trials in the women’s health topics listed below.

Current Clinical Trials in Contraception and Birth Control

Copper IUD Comparison Study
The purpose of this study is to investigate how an investigational copper IUD compares to the FDA approved ParaGard in patient satisfaction and preventing pregnancy. PI: Jeffrey Jensen MD, MPH eIRB #16899

Emergency Contraception and BMI
The purpose of this study is to improve the effectiveness of orally-dosed emergency contraceptives for women of higher BMIs. eIRB: 16291 PI: Alison Edelman, MD MPH

Implant-related Bleeding Study
The purpose of the study is to learn whether a medication called tamoxifen taken a few days per month can help reduce irregular bleeding in women who use the contraceptive implant (Implanon or Nexaplon). PI: Dr. Alison Edelman IRB: 16519

Mirena Extended Trial (MET)
The purpose of this study is to research extended use of the Mirena IUD. Currently, the Mirena IUD is approved to prevent pregnancy for 5 years. This study will help researchers assess if the Mirena IUD is effective and safe beyond 5 years and up to 8 years of use. Additionally, researchers hope to learn more about the safety and tolerability of the study IUD. PI: Jeffrey Jensen, MD, MPH eIRB #16655

Reducing Bleeding with the Hormonal IUD
The Women's Health Research Unit is recruiting for a clinical research study evaluating if a drug can help reduce irregular bleeding in women who are starting the hormonal IUD (Mirena or Liletta). eIRB #15881, PI: Jeffrey Jensen, MD.

TelAbortion Study
The purpose of this study is to assess service provision of medical abortion through telemedicine. eIRB #15974 www.telemedstudy.org

Current Clinical Trials in Urogynecology

There are currently no clinical trials in this category available for enrollment. Please check back soon.

Current Clinical Trials in Pregnancy and Infertility

Brain Complement and Preeclampsia
Our long term goal is to determine how immune factors contribute to brain inflammation and cardiovascular health in women affected by preeclampsia. Kathleen Brookfield, MD eIRB #15344

Functional Imaging of the Human Placenta by MRI
The purpose of this study is to use magnetic resonance imaging (MRI) to measure blood flow to the placenta during pregnancy. Maternal blood carries the oxygen an nutrients that the baby needs to grow and develop. This blood goes to the placenta which controls the exchange of nutrients to the baby and removal of waste products from the baby. The ability to look at blood flow whilst a baby is still in the womb will help obstetricians to find women who have poor blood flow (known as placental insufficiency) during pregnancy. Finding these potential problems during pregnancy, rather than delivery, may allow medical staff to intervene and give the best possible outcome for the baby.  eIRB #15196, PI: Antonio Frias, MD

Infant Brain Development Study
We are looking to better understand healthy brain development. We are studying brain systems important for learning, problem solving and mental health. We hope to learn how these brain systems are unique to each person, beginning in infancy. We also hope to learn how early brain development relates to genes and the prenatal environment. PI: Damien Fair, PA-C, PhD eIRB #15099

Maternal Body Composition Regulates Placental Function and Fetal Growth
The purpose of this research study is to learn more about how a pregnant woman’s body type (amount of muscle and fat) and food choices affect the nutrients transported from the placenta to the baby. We want to learn how this impacts the baby’s growth through the first year of life, and see if there are differences in growth between male and female babies. eIRB# 11175, PI: Nicole Marshall, MD, MCR

Maternal Well-Being Study
We are interested in working with pregnant women to promote well-being, support mothers and babies bonding, reduce stress, and support healthy fetal and infant brain development.<br />Kristen Mackiewicz Seghete, PhD eIRB #17203

Myo-inositol in Pregnancy
Purpose of the study is to learn if myo-inositol supplements (supplement in the B-vitamin family) affect your blood sugar and how your body processes food for energy. eIRB #15080, PI: Amy M. Valent, DO

Optimizing Management of the Second Stage of Labor (OMSS): A Multicenter Trial
The purpose of this study is to assess the effectiveness of immediate pushing at complete cervical dilation on the rate of spontaneous vaginal delivery and pelvic floor muscle injury in nulliparous women. eIRB# 10411, PI: Aaron Caughey, MD, PhD

Placenta Repository: A Study of Placental Function in Healthy and Pathological Pregnancies
Our long term goal is to identify pregnancies that are at risk of poor outcomes and to develop methods for prevention and treatment. eIRB # 16328; PI: Leonardo Pereira, MD

Randomized Trial of Magnesium Sulfate Dosing in Preeclampsia
The purpose of the study is to determine if an alternate magnesium sulfate dosing regiment in preeclamptic pregnant women with BMI > 35kg/m2 will result in a larger proportion of obese women who have therapeutic serum magnesium levels (>4.8 mg/dl) for seizure prophylaxis after 4 hours of administration and at the time of delivery. Kathleen Brookfield, MD, PhD eIRB #15809

SCUBA Study
The purpose of this study is to learn more about a test that may be able to quickly identify women at risk of intra amniotic infection (IAI). PI: Dr. Leonardo Pereira, MD, MCR eIRB# 17000

VentFirst: A multicenter RCT of assisted ventilation during delayed cord clamping for micro-preemies
The purpose of this study is to determine whether delaying clamping of the umbilical cord up to 120 seconds and assisting breathing for extremely premature babies during that time reduces intraventricular hemorrhage (bleeding in the brain). eIRB #15777 PI: Jamie B. Warren, MD, MPH

Current Clinical Trials in Menopause

There are currently no clinical trials in this category available for enrollment. Please check back soon.

Clinical Trials in Menstruation

There are currently no clinical trials in this category available for enrollment. Please check back soon.

Current clinical trials in Women's and Gynecologic Cancers 

In partnership with the Knight Cancer Institute

Find current trials involving ovarian, uterine and cervical cancers

Current Clinical Trials in other areas of women’s health

Biobehavioral Lactation Outcomes Following Oxytocin Administration During Parturition
The purpose of this study is to learn more about maternal hormone levels involved in lactation and their relationship to breastfeeding outcomes in women who received oxytocin as part of their birth experience compared to those who did not. Cathy L. Emeis, CNM, PhD, eIRB #15142

Treating Where it Hurts - Sexual Pain Study
The purpose of this study is to learn about the use of a low-dose estrogen cream applied in a new way to the vaginal entryway for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women. PI: Martha F. Goetsch MD, MPH eIRB# 16770