Laura Newell, MD
Knight Cancer Institute
Division of Hematology/Medical Oncology
Primary Mentor: Grover Bagby, MD
Mentors: Leonardo Pereira, MD, MCR; Jeffrey Tyner, PhD; Irina Burd, MD, PhD
Dr. Newell is a hematologist and hematopoietic stem cell transplant physician interested in responses of the innate immune system and inflammatory cytokine signaling pathways. She is currently investigating the role of the innate immune system in driving pathologic inflammatory responses to viral infections during pregnancy that may contribute to excessive fetal and maternal morbidity and mortality. Her goal is to pursue clinical investigation of novel, targeted therapies specifically for women with viral infections and post-viral inflammatory complications during pregnancy.
Project Title: PIGF enhances viral-induced innate immune inflammatory responses in human mononuclear phagocytes; a potential mechanism for virus related morbidity and mortality in pregnancy.
Ganesh Cherala, PhD
OSU/OHSU College of Pharmacy
Primary Mentor: Kent Thornburg, PhD
Mentors: Mitchell Turker, PhD, JD; Alison Edelman, MD, MPH; George Giraud, MD, PhD
One of the keys to develop successful personalized medicine lies with better understanding of various sources of inter-individual variability in pharmacokinetics. Dr. Cherala has been undertaking multidisciplinary research to understand the contribution of intrauterine growth restriction towards inter-individual variability of drug response. The current grant application is a continuation of those efforts, which integrates intrauterine growth restriction and adulthood obesity, and their combined effect on failure of oral contraception.
Project Title: Prenatal growth programs oral contraceptive metabolism and effectiveness.
Janne Boone-Heinonen, PhD, MPH
Assistant Professor of Epidemiology
Department of Public Health and Preventive Medicine
Primary Mentor: Stephen Fortmann, MD
Mentors: Kent Thornburg, PhD; Kenneth Rosenberg, MD, MPH; Nancy Press, PhD
Dr. Boone-Heinonen is an epidemiologist with an overarching interest in social, environmental, and biological factors drivers of obesity in diverse populations. In ongoing research, she investigates modifiable environmental and behavioral determinants of diet, physical activity, and obesity using complex analytic methods. She is currently developing expertise in biological drivers of obesity that arise in early life, with the goal of developing future research on how biological and social factors interact to impact lifelong health and produce persistent, inter-generational health disparities.
ProjectTitle: Life Course Impacts on Obesity and Health Disparities: Integration of Perinatal Health
Jing Xu, PhD
Oregon National Primate Research Center
Primary Mentor: Richard Stouffer, PhD
Mentors: Mary Zelinski, PhD; Betsy Ferguson, PhD; David Lee, MD
Dr. Xu is interested in studying the mechanisms and regulation of ovarian folliculogenesis, as well as endocrine/paracrine pathways that influence follicular development and oocyte maturation in primates. While performing basic research, translational efforts will be made on human in vitro follicle maturation that may offer a means to enhance fertility options for women, including female cancer patients. Dr. Xu's long-term goal is to build an independent program in biomedical research which can be translated to clinical use to improve or control fertility, and hence women's health.
Project Title: Anti-Müllerian Hormone in Primate Folliculogenesis and Fertility Preservation