Current Studies
The Department of Urology supports an array of research efforts led by faculty in the areas of laboratory-based translational science, outcomes research, and clinical trials. Each of our faculty have grounded commitments to furthering the research mission of the department, and many of the current efforts in clinical research are filling a much needed role of treating, managing, and preventing urologic disorders among our patients and all others suffering from urologic conditions.
Here are a few of the current projects led by Urology faculty:
Flexible ureteroscopy durability and cost
PI: Brian Duty
This is a multi-center prospective study examining the durability and cost of use associated with reusable flexible ureteroscopes.
Extracorporeal shock wave lithotripsy in the Pacific Northwest
PI: Brian Duty
This is a retrospective cohort study describing the ESWL experience in the Pacific Northwest through data analysis on cases from the largest ESWL device group in the region.
Imaging prostatic lipids to distinguish aggressive prostate cancer
Co-I: Christopher Amling and Mark Garzotto
This is a prospective trial examining the ability of MRSI to detect, through imaging of concentrated areas of lipid presence within the prostate, aggressive prostate cancer, and distinguish this from lower risk disease.
Assessing prostate cancer outcomes in rural and urban Oregon
PI: Christopher Amling
This is a retrospective cohort study examining the prevalence and patterns of prostate cancer diagnoses and treatments in the state of Oregon through analysis of data extracted from the state cancer registry.
Vasal fluid evaluation at time of vasectomy reversal
PI: Jason Hedges
The purpose of this study is to evaluate the vasal fluid protein composition found in the male patient at the time of vasectomy reversal, determine if the composition differs between patients of varying operative findings, and learn whether this analysis can further predictive ability.
Impact of inflatable penile prosthesis insertion on lower urinary tract symptoms
PI: Jason Hedges
The objective of this study is to evaluate the effect of IPP placement on patient LUTS, through an analysis of two institutions' cohorts of patients undergoing this procedure.
Fertility registry
Co-PI: Jason Hedges and Eugene Fuchs
This is a prospective multi-institutional registry collecting data on male patients seeking fertility consultations.
Recent publications
Clennon, EK, I Fields, B Cooper, C Seideman. Testicular Torsion is Overrepresented Among Malpractice Cases for Gonadal Torsion. J Ped Surg, 2022. In Press.
Bash J, Lo J, Kapadia A, Mason M, Hedges J. Vasectomy reversal outcomes in men after testosterone therapy. Sci Rep 12, 19496 (2022).
Wenzel J, Bassale S, Jones P, Robinson E, Isharwal S, Amling CL, Sajadi K, Liu JJ. Early stent removal after radical cystectomy. Western Section AUA, Oct 30 –Nov 4, 2022, Kauai, HI.
Hayes M, Bassale S, Chakiryan N, Boileau L, Grassauer J, Wagner M, Foster B, Coakley F, Isharwal S, Amling CL, Liu JJ. (2022). Selecting patients for magnetic resonance imaging cognitive versus ultrasound fusion biopsy of the prostate: A within‐patient comparison. BJUI Compass. 2022 Jun 5;3(6):443-449. PMID: 36267201; PMCID: PMC9579877.
Hayes M, Grassauer J, Liu JJ, Amling CL, Bedrick S, Isharwal S. Using a Novel Text Preprocessing Strategy with a Bag-of-N Grams Representation for Automated Data Extraction of Prostate Biopsy Pathology Reports. Western Section AUA, Oct 30 – Nov 4, 2022, Kauai, HI.
Wenzel J, Bassale S, Jones P, Robinson E, Isharwal S, Amling CL, Sajadi K, Liu JJ. Early stent removal after radical cystectomy. Western Section AUA, Oct 30 –Nov 4, 2022, Kauai, HI.
Alexandra Medline, Reza Nabavizadeh, Thien-Linh Le, Dattatraya Patil, Sean Evans, Alex Sandbery, Sarah P. Psutka, Viraj A. Master. Magnetic resonance imaging vs. computed tomography image concordance for linear measurements and the quantification of abdominal skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle Clinical reports, 2022.
DOI:10.1002/crt2.46
Tzou DT, Stern KL, Duty BD, Hsi RS, Canvasser NE, De S, Wong AC, Royal CR, Sloss ML, Ziemba JB, Harper JD, Bechis SK, Zampini AM, Borofsky MS, Bell JR, Friedlander JI, Leavitt DA, Nevo A, Patel ND, Patel RM, Okeke Z, Rivera ME, Hsu CH, Chi T, Vedantam G, Lainhart WD. Heterogeneity in stone culture protocols and endourologist practice patterns: a multi-institutional survey. Urolithiasis. 2022 Dec 12;51(1):15.
Sineath C, Butler C, Dy GW, Dugi D. Genital Hypoplasia in Gender-affirming Vaginoplasty: Prior Orchiectomy, Penile Length, and Other Factors to Guide Surgical Planning. J Urol. 2022 Aug
Scull, D., Chung, P., Dugi, D., Dy, G. Creating a Gender- Affirming Environment for Urologic Care. AUA News, April 2021.
Metzler, Ian & Holt, Sarah & Harper, Jonathan. (2021). Surgical Trends in Nephrolithiasis – Increasing de novo renal access by urologists for PCNL. Journal of Endourology. 35. 10.1089/end.2020.0888.
Hedges JC, Hanna CB, Bash JC*, Boniface ER, Burch FC, Mahalingaiah S, Roberts VHJ, Terrobias JJD, Mishler EC, Jensen JV, Easley CA, Lo JO. Chronic delta-9-tetrahydrocannabinol exposure impacts testicular volume and male reproductive health in rhesus macaques. Fertil Steril. 2022. Accepted
***Highlighted by the American Society of Reproductive Medicine Bulletin and Press Release including a Jimmy Kimmel monologue
Hayes M, Bassale S, Chakiryan N, Boileau L, Grassauer J, Wagner M, Foster B, Coakley F, Isharwal S, Amling CL, Liu JJ. (2022). Selecting patients for magnetic resonance imaging cognitive versus ultrasound fusion biopsy of the prostate: A within‐patient comparison. BJUI Compass. 2022 Jun 5;3(6):443-449. PMID: 36267201; PMCID: PMC9579877.
Wang A, Robinson E, Chouhan JD. Minimizing opioids after gender affirming orchiectomy- a multimodal pain pathway. Accepted to the Canadian Journal of Urology, December 2022.
Senders A, Bauer SR, Chen Y, Oken B, Fink HA, Lane NE, Sajadi KP, Marshall LM for the Osteoporotic Fractures in Men (MrOS) Study Group. Musculoskeletal pain, a possible indicator of central sensitization, is positively associated with lower urinary tract symptom progression in community dwelling older men. JGMS 2022, in press.
Wenzel JL*, Bassale S, Jones P, Robinson E, Isharwal S, Amling C, Sajadi KP, Liu JJ. Early stent removal after radical cystectomy. Western Section American Urological Association Annual Meeting, Kauai, HI, October 2022.
Strother MC, Cho EY, Loecher M, et al. The Delayed Nephrogram: Point-of-care Quantitative Measurement, Validation as an Indicator of Obstruction, and Novel Use as a Predictor of Renal Functional Impairment. Eur Urol Focus. 2022.
doi:10.1016/J.EUF.2022.01.019
Suskind AM, Vaittinen T, Gibson W, Hajebrahimi S, Ostaszkiewicz J, Davis N, Dickinson T, Spencer M, Wagg A. International Continence Society white paper on ethical considerations in older adults with urinary incontinence. Neurourol Urodyn. 2022 Jan
Hayes M, Yu Y, Bassale S, Chakiryan N, Chen Y, Ye S, Garzotto M, Kopp R. Calibrated Regression Models Based on the Risk of Clinical Nodal Metastasis Should be Used as Decision Aids for Prostate Cancer Staging to Reduce Unnecessary Imaging. Clin Genitourin Cancer. 2022 Dec;20(6):e490-e497. PMID: 35649886.
Song X, Ru M, Steinsnyder Z, Tkachuk K, Kopp RP, Sullivan J, Gümüş ZH, Offit K, Joseph V, Klein RJ. SNPs at SMG7 Associated with Time from Biochemical Recurrence to Prostate Cancer Death. Cancer Epidemiol Biomarkers Prev. 2022 Jul 1;31(7):1466-1472. PMID: 35511739; PMCID: PMC9250608.
Iguchi N, HECHT SL, Gao D, Wilcox DT, Malykhina AP, Cost NG. Sexual dimorphic impacts of systemic vincristine on lower urinary tract function. Scientific Reports 2022; 12(1): 1-15.
Flewelling KD, Wengryn D, Buchanan CL, Vemulakonda VM, Beltran GG, HECHT SL. Unexpected Challenges Faced by Caregivers of Children with Neurogenic Bladder: A Qualitative Study. Journal of Pediatric Urology 2022; 18(4): 502.e1-502.e9.