Laurence Trussell, Ph.D., Professor

Laurence Trussell

Email: trussell@ohsu.edu
Phone: 503 494-3424
Lab phone: 503 494-3409
Office: MRB 924

 

Background

Laurence Trussell received his Ph.D. in Biology from the University of California, Los Angeles in 1983. After initial postdoctoral work at UCLA, he obtained further training at Washington University, St. Louis. In 1990, he received a faculty appointment at the University of Wisconsin, Madison. In 1999, he was appointed as professor in the Oregon Hearing Research Center with an appointment as scientist at the Vollum Institute.

Overview

Current appointments:

  • Professor in the Department of Otolaryngology-Head and Neck Surgery
  • Scientist with the Vollum Institute

Previous appointments:

  • Associate Professor in the Department of Otolaryngology-Head and Neck Surgery

 Degrees:

  • B.A. degree in biology from University of California-San Diego
  • Ph.D. degree in biology from University of California-San Diego
  • Postdoctoral work at UCLA  and Washington University

Summary of current research

Research Interests

  • Brainstem circuits that process acoustic signals
  • Synaptic physiology - how do cells and synapses preserve information provided by the ear?

Major Milestones and Significant Discoveries

  • Neurons that encode timing of acoustic signals are molecularly and biophysically specialized for that function
  • Cellular/synaptic learning mechanisms occur even at the earliest levels of sensory processing
  • Corelease of multiple transmitters from neurons act together on the same receptor
  • Ca2+ channels are expressed in axons and control the triggering of complex spike activity.

In addition to his appointment with the Oregon Hearing Research Center, Dr. Trussell is a Scientist with the Vollum Institute. To access his publications,  click here to go to PubMed.

Selected publications

  1. Bender, K. J., Ford, C. P., & Trussell, L. O. (2010). Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation. Neuron, 68(3), 500-51. pdf
  2. Huang, H., & Trussell, L. O. (2011). KCNQ5 channels control resting properties and release probability of a synapse. Nat Neurosci, 14(7), 840-847. pdf
  3. Kuo, S. P., & Trussell, L. O. (2011). Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition. Neuron, 71(2), 306-318. pdf
  4. Kuo, S. P., Lu, H. W., & Trussell, L. O. (2012). Intrinsic and synaptic properties of vertical cells of the mouse dorsal cochlear nucleus. J Neurophys, 108(4), 1186-1198. pdf
  5. Bender, K. J., Uebele, V. N., Renger, J. J., & Trussell, L. O. (2012). Control of firing patterns through modulation of axon initial segment T‐type calcium channels. J Physiol, 590(1), 109-118. pdf
  6. Bender, K. J., & Trussell, L. O. (2012). The physiology of the axon initial segment. Ann Rev Neurosci, 35, 249-265. pdf
  7. Bender, K. J., Uebele, V. N., Renger, J. J., & Trussell, L. O. (2012). Control of firing patterns through modulation of axon initial segment T‐type calcium channels. J Physiol, 590(1), 109-118. pdf
  8. Apostolides, P. F., & Trussell, L. O. (2013). Regulation of interneuron excitability by gap junction coupling with principal cells. Nat Neurosci, 16(12), 1764-1772. pdf
  9. Apostolides, P. F., & Trussell, L. O. (2014). Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus. Neuron, 83(2), 324-330. pdf
  10. Apostolides, P. F., & Trussell, L. O. (2014). Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus. J Neurophys, 111(9), 1812-1822. pdf
  11. Huang, H., & Trussell, L. O. (2014). Presynaptic HCN channels regulate vesicular glutamate transport. Neuron, 84(2), 340-346. pdf
  12. Tang, Z. Q., & Trussell, L. O. (2015). Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus. J Neurosci, 35(11), 4540-4551. pdf
  13. Yaeger, D. B., & Trussell, L. O. (2015). Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci, 35(11), 4741-4750. pdf
  14. Borges-Merjane, C., & Trussell, L. O. (2015). ON and OFF unipolar brush cells transform multisensory inputs to the auditory system. Neuron, 85(5), 1029-1042. pdf
  15. Lu, H. W., & Trussell, L. O. (2016). Spontaneous Activity Defines Effective Convergence Ratios in an Inhibitory Circuit. J Neurosci, 36(11), 3268-3280. doc