OHSU

Alfred L. Nuttall, PhD OHRC Lab

Fred Nuttall

NUTTALL LABORATORY

Dr. Nuttall's research specialization is in cochlear physiology with a dual focus on cochlear mechanics and cochlear blood flow. In the study of cochlear mechanics, his laboratory currently works on determining the micromechanical motions, forces, and electrochemical signals needed for the "cochlear amplifier." The biological amplifier powers the extraordinary sensitivity of the ear for detection of sound. For the area of cochlear blood flow, his laboratory studies the cellular mechanisms of noise-induced hearing loss in the vascular tissue and in the sensory cells of the organ of Corti. This damage includes a form of stress induced inflammation. The goal of the laboratory is to understand the molecular mechanisms of the damage from exposure to loud sound. An additional goal is to develop imaging technology for the clinical assessment of altered blood flow in the human ear and for the diagnosis of Ménière's disease.  

Current Nuttall Lab Members are:

Sripriya Ramamoorthy
Senior Research Associate

Teresa Wilson
Senior Research Associate

Sarah Foster
Research Assistant 2

Yuan Zhang
Research Assistant 2

 

Nuttall Support staff:

Christine Casabar
Executive Specialist

DR. NUTTALL'S RECENT PUBLICATIONS

  1. Subhash, M.S., Nguyen-Huynh, A., Wang, R.K., Jacques, S.L. and Nuttall, A.L. Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear virometry. J Biomed Opt (2012) 17(6):060505. doi:10.1117/1.JBO.17.6.060505
  2. Dziennis, S., Reif, R., Zhi, Z., Nuttall, A.L. and Wang, R.K. Effects of hypoxia on cochlear blood flow in mice evaluated using Doppler optical microangiography. J Biomed Opt (2012) 17(10):106003. doi:10.1117/1.JBO.17.10.106003.
  3. Reif, R., Qin, J., Dziennis, S., Zhi, Z., Nuttall, A.L. and Wang, R.K. Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system. PLoS One (2012) 7(12):e52041. doi: 10.1371/journal.pone.0052041.
  4. Subhash, M.S., Choudhury, N., Chen, F., Wang, R.-K., Jacques, S. and Nuttall, A.L. Depth-resolved absolute vibrometry based on Fourier domain low coherence interferometry. J Biomed Opt (2013) 18(3):036003. doi:10.1117/1.JBO.18.3.036003.
  5. Han, W.J., Shi, X. and Nuttall, A.L. Noise-induced nitrotyrosine increase and out hair cell death in the guinea pig cochlea. Chin Med J (2013), 126(15):2923-2927.
  6. Reif, R., Zhi, Z., Dziennis, S., Nuttall, A.L. and Wang, R.K.  Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry. Quant Imaging Med Surg (2013) 3(5):235-42.
  7. Ramamoorthy, S. Wilson, T., Wu, T. and Nuttall, A.L. Non-uniform distribution of outer hair cell transmembrane potential induced by extracellular electrical field. Biophys J (2013) 105(12):2666-75.
  8. Ren, T., Zheng, J., He, W. and Nuttall, A.L. Measurement of amplitude and delay of stimulus frequency otoacoustic emissions. J Otol (2013) 8(1):57-63.
  9. Le Floc'h, J., Tan, W., Telang, R.S., Vlajkovic, S.M., Nuttall, A.L., Rooney, W.D., Pontre, B. and Thorne, P.R. Markers of cochlear inflammation using MRI. J Magn Reson Imaging (2014) 39(1):150-61.
  10. Shi, X., Zhang, F., Urdang, Z., Dai, M., Neng, L., Zhang, J., Ramamoorthy, S. and Nuttall, A.L. Thin and open vessel-windows for intra-vital fluorescence microscopy imaging of the murine cochlear lateral wall. (2014) Hear Res 313:38-46.