OHSU

Alfred L. Nuttall, PhD OHRC Lab

Fred Nuttall

NUTTALL LABORATORY

Dr. Nuttall's research specialization is in cochlear physiology with a dual focus on cochlear mechanics and cochlear blood flow. In the study of cochlear mechanics, his laboratory currently works on determining the micromechanical motions, forces, and electrochemical signals needed for the cochlear amplifier. The amplifier powers the extraordinary sensitivity of the ear for detection of sound. For the area of cochlear blood flow, his laboratory studies the cellular mechanisms of noise-induced hearing loss in the vascular tissue and in the sensory cells of the organ of Corti. This damage includes a form of stress induced inflammation. The goal of the laboratory is to understand the molecular mechanisms of the damage from exposure to loud sound. An additional goal is to develop imaging technology for the clinical assessment of altered blood flow in the human ear and for the diagnosis of Ménière's disease.  

Current Nuttall Lab Members are:

Sripriya Ramamoorthy
Senior Research Associate

Teresa Wilson
Senior Research Associate

Sarah Foster
Research Assistant 2

Yuan Zhang
Research Assistant 2

 

Nuttall Support staff:

Christine Casabar
Executive Specialist

DR. NUTTALL'S RECENT PUBLICATIONS

  1. 1.Wu, T., Dai, M., Shi, X., and Nuttall, A.L. Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol (2011) 301(1):H69–78. PMC3129919 005983, 000141,008888, 008888S1, 010844, 004716
  2. 2.Ramamoorthy, S. and Nuttall, A.L. Outer hair cell somatic electromotility in vivo and power transfer to the organ of Corti. Biophys J (2012) 102:388-398. PMC3274794 00141
  3. 3.He, W., Porsov, E., Kemp, D., Nuttall, A.L., Ren, T.The group delay and suppression pattern of the cochlear microphonic potential recorded at the round window. PloS One (2012) 7(3):e34356. PMC3314608 ?unknown?
  4. 4.Zha, D., Chen, F., Ramamoorthy, S., Fridberger, A., Choudhury, N., Jacques, S.L., Wang, R.K., and Nuttall, A.L. In vivo outer hair cell length changes expose the active process in the cochlea. PLoS One (2012) 7(4):e32757. PMC3322117 00141 10399
  5. 5.Ramamoorthy, S. and Nuttall, A.L. Half-octave shift in mammalian hearing is an epiphenomenon of the cochlear amplifier. PLoS One (2012) 7(9): e45640. PMC3458085 00141
  6. 6.Subhash, M.S., Nguyen-Huynh, A., Wang, R.K., Jacques, S.L. and Nuttall, A.L. Feasibility of spectral-domain phase-sensitive optical coherence tomography for the middle ear virometry. J Biomed Opt (2012) 17(6):060505. PMC3381045 00141 05983
  7. 7.Dziennis, S., Reif, R., Zhi, Z., Nuttall, A.L. and Wang, R.K. Effects of hypoxia on cochlear blood flow in mice evaluated using Doppler optical microangiography. J Biomed Opt (2012) 17(10): 106003. PMC3461130 00105 05983
  8. 8.Reif, R., Qin, J., Dziennis, S., Zhi, Z., Nuttall, A.L. and Wang, R.K. Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system. PLoS One (2012) 7(12): e52041. PMC3525546 00105 05983
  9. 9.Subhash, M.S., Choudhury, N., Chen, F., Wang, R.-K., Jacques, S. and Nuttall, A.L. Depth-resolved absolute vibrometry based on Fourier domain low coherence interferometry. J Biomed Opt (2013) Mar 1; 18(3):36003. PMC3584824 005983, 00141 10399
  10. 10.Le Floc'h, J., Tan, W., Telang, R.S., Vlajkovic, S.M., Nuttall, A.L., Rooney, W.D., Pontre, B. and Thorne, P.R. Markers of cochlear inflammation using magnetic resonance imaging. J Magn Reson Imaging (April, 2013) doi/10.1002/jmri.24144/pdf.