Soo Lee Lab
Unraveling the processes that generate the numerous neuronal subtypes and establish their appropriate connections to form a functional CNS is one of the main challenges in neuroscience today. Particularly, decoding the gene regulatory network responsible for neuronal subtype specification is a fundamental step toward understanding the CNS development and advancing methods to generate specific neurons in regenerative medicine.
Our goal is to develop a comprehensive map of the complex gene regulatory networks that direct cell-fate specification and assembly of neuro-circuits. Our major model systems include the spinal cord, which consists of distinct classes of neurons to assemble motor and sensory circuits, and the arcuate nucleus of the hypothalamus, which forms a core neuro-circuitry that mediates actions of peripheral adiposity-signals, leptin and insulin, for energy balance.
"Our Imagination is the only limit to what we can hope to have in the future"
-Charles F. Kettering-